Respiratory Viruses in Solid Organ Transplant Recipients

Solid organ transplantation is often lifesaving, but does carry an increased risk of infection. Respiratory viral infections are one of the most prevalent infections, and are a cause of significant morbidity and mortality, especially among lung transplant recipients. There is also data to suggest an...

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Autores principales:	Roni Bitterman, Deepali Kumar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vaccine prevention lung transplant influenza RSV metapneumovirus Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4b2c82bd025a444784a3abc17e7eafe4
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spelling	oai:doaj.org-article:4b2c82bd025a444784a3abc17e7eafe42021-11-25T19:12:44ZRespiratory Viruses in Solid Organ Transplant Recipients10.3390/v131121461999-4915https://doaj.org/article/4b2c82bd025a444784a3abc17e7eafe42021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2146https://doaj.org/toc/1999-4915Solid organ transplantation is often lifesaving, but does carry an increased risk of infection. Respiratory viral infections are one of the most prevalent infections, and are a cause of significant morbidity and mortality, especially among lung transplant recipients. There is also data to suggest an association with acute rejection and chronic lung allograft dysfunction in lung transplant recipients. Respiratory viral infections can appear at any time post-transplant and are usually acquired in the community. All respiratory viral infections share similar clinical manifestations and are all currently diagnosed using nucleic acid testing. Influenza has good treatment options and prevention strategies, although these are hampered by resistance to neuraminidase inhibitors and lower vaccine immunogenicity in the transplant population. Other respiratory viruses, unfortunately, have limited treatments and preventive methods. This review summarizes the epidemiology, clinical manifestations, therapies and preventive measures for clinically significant RNA and DNA respiratory viruses, with the exception of SARS-CoV-2. This area is fast evolving and hopefully the coming decades will bring us new antivirals, immunologic treatments and vaccines.Roni BittermanDeepali KumarMDPI AGarticlevaccinepreventionlung transplantinfluenzaRSVmetapneumovirusMicrobiologyQR1-502ENViruses, Vol 13, Iss 2146, p 2146 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vaccine prevention lung transplant influenza RSV metapneumovirus Microbiology QR1-502
spellingShingle	vaccine prevention lung transplant influenza RSV metapneumovirus Microbiology QR1-502 Roni Bitterman Deepali Kumar Respiratory Viruses in Solid Organ Transplant Recipients
description	Solid organ transplantation is often lifesaving, but does carry an increased risk of infection. Respiratory viral infections are one of the most prevalent infections, and are a cause of significant morbidity and mortality, especially among lung transplant recipients. There is also data to suggest an association with acute rejection and chronic lung allograft dysfunction in lung transplant recipients. Respiratory viral infections can appear at any time post-transplant and are usually acquired in the community. All respiratory viral infections share similar clinical manifestations and are all currently diagnosed using nucleic acid testing. Influenza has good treatment options and prevention strategies, although these are hampered by resistance to neuraminidase inhibitors and lower vaccine immunogenicity in the transplant population. Other respiratory viruses, unfortunately, have limited treatments and preventive methods. This review summarizes the epidemiology, clinical manifestations, therapies and preventive measures for clinically significant RNA and DNA respiratory viruses, with the exception of SARS-CoV-2. This area is fast evolving and hopefully the coming decades will bring us new antivirals, immunologic treatments and vaccines.
format	article
author	Roni Bitterman Deepali Kumar
author_facet	Roni Bitterman Deepali Kumar
author_sort	Roni Bitterman
title	Respiratory Viruses in Solid Organ Transplant Recipients
title_short	Respiratory Viruses in Solid Organ Transplant Recipients
title_full	Respiratory Viruses in Solid Organ Transplant Recipients
title_fullStr	Respiratory Viruses in Solid Organ Transplant Recipients
title_full_unstemmed	Respiratory Viruses in Solid Organ Transplant Recipients
title_sort	respiratory viruses in solid organ transplant recipients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4b2c82bd025a444784a3abc17e7eafe4
work_keys_str_mv	AT ronibitterman respiratoryvirusesinsolidorgantransplantrecipients AT deepalikumar respiratoryvirusesinsolidorgantransplantrecipients
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Respiratory Viruses in Solid Organ Transplant Recipients

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