High resolution spectral domain optical coherence tomography (SD-OCT) in multiple sclerosis: the first follow up study over two years.

<h4>Background</h4>"Non-invasive, faster and less expensive than MRI" and "the eye is a window to the brain" are recent slogans promoting optical coherence tomography (OCT) as a new surrogate marker in multiple sclerosis (MS). Indeed, OCT allows for the first time a n...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nermin Serbecic, Fahmy Aboul-Enein, Sven C Beutelspacher, Clemens Vass, Wolfgang Kristoferitsch, Hans Lassmann, Andreas Reitner, Ursula Schmidt-Erfurth
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b2e5cf113b6442c899b43764512a137
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4b2e5cf113b6442c899b43764512a137
record_format	dspace
spelling	oai:doaj.org-article:4b2e5cf113b6442c899b43764512a1372021-11-18T06:53:50ZHigh resolution spectral domain optical coherence tomography (SD-OCT) in multiple sclerosis: the first follow up study over two years.1932-620310.1371/journal.pone.0019843https://doaj.org/article/4b2e5cf113b6442c899b43764512a1372011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21611198/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>"Non-invasive, faster and less expensive than MRI" and "the eye is a window to the brain" are recent slogans promoting optical coherence tomography (OCT) as a new surrogate marker in multiple sclerosis (MS). Indeed, OCT allows for the first time a non-invasive visualization of axons of the central nervous system (CNS). Reduction of retina nerve fibre layer (RNFL) thickness was suggested to correlate with disease activity and duration. However, several issues are unclear: Do a few million axons, which build up both optic nerves, really resemble billions of CNS neurons? Does global CNS damage really result in global RNFL reduction? And if so, does global RNFL reduction really exist in all MS patients, and follow a slowly but steadily ongoing pattern? How can these (hypothesized) subtle global RNFL changes be reliably measured and separated from the rather gross RNFL changes caused by optic neuritis? Before generally being accepted, this interpretation needs further critical and objective validation.<h4>Methodology</h4>We prospectively studied 37 MS patients with relapsing remitting (n = 27) and secondary progressive (n = 10) course on two occasions with a median interval of 22.4±0.5 months [range 19-27]. We used the high resolution spectral domain (SD-)OCT with the Spectralis 3.5 mm circle scan protocol with locked reference images and eye tracking mode. Patients with an attack of optic neuritis within 12 months prior to the onset of the study were excluded.<h4>Principal findings</h4>Although the disease was highly active over the observation period in more than half of the included relapsing remitting MS patients (19 patients/32 relapses) and the initial RNFL pattern showed a broad range, from normal to markedly reduced thickness, no significant changes between baseline and follow-up examinations could be detected.<h4>Conclusions</h4>These results show that caution is required when using OCT for monitoring disease activity and global axonal injury in MS.Nermin SerbecicFahmy Aboul-EneinSven C BeutelspacherClemens VassWolfgang KristoferitschHans LassmannAndreas ReitnerUrsula Schmidt-ErfurthPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e19843 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nermin Serbecic Fahmy Aboul-Enein Sven C Beutelspacher Clemens Vass Wolfgang Kristoferitsch Hans Lassmann Andreas Reitner Ursula Schmidt-Erfurth High resolution spectral domain optical coherence tomography (SD-OCT) in multiple sclerosis: the first follow up study over two years.
description	<h4>Background</h4>"Non-invasive, faster and less expensive than MRI" and "the eye is a window to the brain" are recent slogans promoting optical coherence tomography (OCT) as a new surrogate marker in multiple sclerosis (MS). Indeed, OCT allows for the first time a non-invasive visualization of axons of the central nervous system (CNS). Reduction of retina nerve fibre layer (RNFL) thickness was suggested to correlate with disease activity and duration. However, several issues are unclear: Do a few million axons, which build up both optic nerves, really resemble billions of CNS neurons? Does global CNS damage really result in global RNFL reduction? And if so, does global RNFL reduction really exist in all MS patients, and follow a slowly but steadily ongoing pattern? How can these (hypothesized) subtle global RNFL changes be reliably measured and separated from the rather gross RNFL changes caused by optic neuritis? Before generally being accepted, this interpretation needs further critical and objective validation.<h4>Methodology</h4>We prospectively studied 37 MS patients with relapsing remitting (n = 27) and secondary progressive (n = 10) course on two occasions with a median interval of 22.4±0.5 months [range 19-27]. We used the high resolution spectral domain (SD-)OCT with the Spectralis 3.5 mm circle scan protocol with locked reference images and eye tracking mode. Patients with an attack of optic neuritis within 12 months prior to the onset of the study were excluded.<h4>Principal findings</h4>Although the disease was highly active over the observation period in more than half of the included relapsing remitting MS patients (19 patients/32 relapses) and the initial RNFL pattern showed a broad range, from normal to markedly reduced thickness, no significant changes between baseline and follow-up examinations could be detected.<h4>Conclusions</h4>These results show that caution is required when using OCT for monitoring disease activity and global axonal injury in MS.
format	article
author	Nermin Serbecic Fahmy Aboul-Enein Sven C Beutelspacher Clemens Vass Wolfgang Kristoferitsch Hans Lassmann Andreas Reitner Ursula Schmidt-Erfurth
author_facet	Nermin Serbecic Fahmy Aboul-Enein Sven C Beutelspacher Clemens Vass Wolfgang Kristoferitsch Hans Lassmann Andreas Reitner Ursula Schmidt-Erfurth
author_sort	Nermin Serbecic
title	High resolution spectral domain optical coherence tomography (SD-OCT) in multiple sclerosis: the first follow up study over two years.
title_short	High resolution spectral domain optical coherence tomography (SD-OCT) in multiple sclerosis: the first follow up study over two years.
title_full	High resolution spectral domain optical coherence tomography (SD-OCT) in multiple sclerosis: the first follow up study over two years.
title_fullStr	High resolution spectral domain optical coherence tomography (SD-OCT) in multiple sclerosis: the first follow up study over two years.
title_full_unstemmed	High resolution spectral domain optical coherence tomography (SD-OCT) in multiple sclerosis: the first follow up study over two years.
title_sort	high resolution spectral domain optical coherence tomography (sd-oct) in multiple sclerosis: the first follow up study over two years.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/4b2e5cf113b6442c899b43764512a137
work_keys_str_mv	AT nerminserbecic highresolutionspectraldomainopticalcoherencetomographysdoctinmultiplesclerosisthefirstfollowupstudyovertwoyears AT fahmyaboulenein highresolutionspectraldomainopticalcoherencetomographysdoctinmultiplesclerosisthefirstfollowupstudyovertwoyears AT svencbeutelspacher highresolutionspectraldomainopticalcoherencetomographysdoctinmultiplesclerosisthefirstfollowupstudyovertwoyears AT clemensvass highresolutionspectraldomainopticalcoherencetomographysdoctinmultiplesclerosisthefirstfollowupstudyovertwoyears AT wolfgangkristoferitsch highresolutionspectraldomainopticalcoherencetomographysdoctinmultiplesclerosisthefirstfollowupstudyovertwoyears AT hanslassmann highresolutionspectraldomainopticalcoherencetomographysdoctinmultiplesclerosisthefirstfollowupstudyovertwoyears AT andreasreitner highresolutionspectraldomainopticalcoherencetomographysdoctinmultiplesclerosisthefirstfollowupstudyovertwoyears AT ursulaschmidterfurth highresolutionspectraldomainopticalcoherencetomographysdoctinmultiplesclerosisthefirstfollowupstudyovertwoyears
_version_	1718424227059597312

High resolution spectral domain optical coherence tomography (SD-OCT) in multiple sclerosis: the first follow up study over two years.

Ejemplares similares