The P. falciparum CSP repeat region contains three distinct epitopes required for protection by antibodies in vivo.

The P. falciparum CSP repeat region contains three distinct epitopes required for protection by antibodies in vivo.

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Rare and potent monoclonal antibodies (mAbs) against the Plasmodium falciparum (Pf) circumsporozoite protein (CSP) on infective sporozoites (SPZ) preferentially bind the PfCSP junctional tetrapeptide NPDP or NVDP minor repeats while cross-reacting with NANP central repeats in vitro. The extent to wh...

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Auteurs principaux: Yevel Flores-Garcia, Lawrence T Wang, Minah Park, Beejan Asady, Azza H Idris, Neville K Kisalu, Christian Muñoz, Lais S Pereira, Joseph R Francica, Robert A Seder, Fidel Zavala
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2021
Sujets:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Accès en ligne:https://doaj.org/article/4b2f0abc1d8945d0affa55beb09edf04
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The P. falciparum CSP repeat region contains three distinct epitopes required for protection by antibodies in vivo
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