Perigeniculate arachnoid cysts and CSF fistulae of the fallopian canal: Histopathologic correlates of a rare clinical entity

Cerebrospinal fluid (CSF) fistulae originating from the fallopian canal of the facial nerve is hypothesized to arise due to atypical patterns of subarachnoid space extension into the geniculate ganglion or more distal regions along the intratemporal course of the facial nerve, but its pathogenesis r...

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Autores principales:	Emerson E. Lee, Nicholas S. Andresen, Bryan McKenzie, Jeffrey D. Sharon, Howard W. Francis, Daniel Q. Sun
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Geniculate ganglion Arachnoid cyst Fallopian canal Facial nerve Cerebrospinal fluid otorrhea Cerebrospinal fluid leak Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/4b312ec8c95741eca655610270901547
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spelling	oai:doaj.org-article:4b312ec8c95741eca6556102709015472021-12-02T15:27:30ZPerigeniculate arachnoid cysts and CSF fistulae of the fallopian canal: Histopathologic correlates of a rare clinical entity2095-881110.1016/j.wjorl.2020.12.005https://doaj.org/article/4b312ec8c95741eca6556102709015472021-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881121000020https://doaj.org/toc/2095-8811Cerebrospinal fluid (CSF) fistulae originating from the fallopian canal of the facial nerve is hypothesized to arise due to atypical patterns of subarachnoid space extension into the geniculate ganglion or more distal regions along the intratemporal course of the facial nerve, but its pathogenesis remains poorly understood. Although a rare etiology of CSF fistulae of the temporal bone, there are significant clinical ramifications due to the risk of recurrent meningitis, difficulty in identifying the anatomic location of the CSF leak, and technical challenges associated with surgical repair. We present three clinical cases of arachnoid cysts within the geniculate fossa with or without CSF fistulization and provide histopathologic correlates of this rare clinical phenomenon from a human temporal bone collection. The pediatric and adult patients presented suggest differential pathophysiologic mechanisms associated with CSF fistulae. Temporal bone histology reveals atypical patterns of subarachnoid space extension in the fallopian canal that may underlie arachnoid cyst formation and overt CSF leak from the geniculate region.Emerson E. LeeNicholas S. AndresenBryan McKenzieJeffrey D. SharonHoward W. FrancisDaniel Q. SunKeAi Communications Co., Ltd.articleGeniculate ganglionArachnoid cystFallopian canalFacial nerveCerebrospinal fluid otorrheaCerebrospinal fluid leakOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 7, Iss 2, Pp 71-81 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geniculate ganglion Arachnoid cyst Fallopian canal Facial nerve Cerebrospinal fluid otorrhea Cerebrospinal fluid leak Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Geniculate ganglion Arachnoid cyst Fallopian canal Facial nerve Cerebrospinal fluid otorrhea Cerebrospinal fluid leak Otorhinolaryngology RF1-547 Surgery RD1-811 Emerson E. Lee Nicholas S. Andresen Bryan McKenzie Jeffrey D. Sharon Howard W. Francis Daniel Q. Sun Perigeniculate arachnoid cysts and CSF fistulae of the fallopian canal: Histopathologic correlates of a rare clinical entity
description	Cerebrospinal fluid (CSF) fistulae originating from the fallopian canal of the facial nerve is hypothesized to arise due to atypical patterns of subarachnoid space extension into the geniculate ganglion or more distal regions along the intratemporal course of the facial nerve, but its pathogenesis remains poorly understood. Although a rare etiology of CSF fistulae of the temporal bone, there are significant clinical ramifications due to the risk of recurrent meningitis, difficulty in identifying the anatomic location of the CSF leak, and technical challenges associated with surgical repair. We present three clinical cases of arachnoid cysts within the geniculate fossa with or without CSF fistulization and provide histopathologic correlates of this rare clinical phenomenon from a human temporal bone collection. The pediatric and adult patients presented suggest differential pathophysiologic mechanisms associated with CSF fistulae. Temporal bone histology reveals atypical patterns of subarachnoid space extension in the fallopian canal that may underlie arachnoid cyst formation and overt CSF leak from the geniculate region.
format	article
author	Emerson E. Lee Nicholas S. Andresen Bryan McKenzie Jeffrey D. Sharon Howard W. Francis Daniel Q. Sun
author_facet	Emerson E. Lee Nicholas S. Andresen Bryan McKenzie Jeffrey D. Sharon Howard W. Francis Daniel Q. Sun
author_sort	Emerson E. Lee
title	Perigeniculate arachnoid cysts and CSF fistulae of the fallopian canal: Histopathologic correlates of a rare clinical entity
title_short	Perigeniculate arachnoid cysts and CSF fistulae of the fallopian canal: Histopathologic correlates of a rare clinical entity
title_full	Perigeniculate arachnoid cysts and CSF fistulae of the fallopian canal: Histopathologic correlates of a rare clinical entity
title_fullStr	Perigeniculate arachnoid cysts and CSF fistulae of the fallopian canal: Histopathologic correlates of a rare clinical entity
title_full_unstemmed	Perigeniculate arachnoid cysts and CSF fistulae of the fallopian canal: Histopathologic correlates of a rare clinical entity
title_sort	perigeniculate arachnoid cysts and csf fistulae of the fallopian canal: histopathologic correlates of a rare clinical entity
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/4b312ec8c95741eca655610270901547
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Perigeniculate arachnoid cysts and CSF fistulae of the fallopian canal: Histopathologic correlates of a rare clinical entity

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