Circulating tumour cells as an indicator of early and systemic recurrence after surgical resection in pancreatic ductal adenocarcinoma

Abstract Early recurrence in pancreatic ductal adenocarcinoma (PDAC) is a decisive factor in determining a patient's prognosis. We determined in our current study whether circulating tumour cells (CTCs) exist in the blood of PDAC patients and can be used as a predictor of recurrence patterns (i...

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Autores principales:	Yejong Park, Hye Ryeong Jun, Hwi Wan Choi, Dae Wook Hwang, Jae Hoon Lee, Ki Byung Song, Woohyung Lee, Jaewoo Kwon, Su Hyeon Ha, Eunsung Jun, Song Cheol Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b331bd32c6c421d861ccfd8231336f2
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spelling	oai:doaj.org-article:4b331bd32c6c421d861ccfd8231336f22021-12-02T13:50:41ZCirculating tumour cells as an indicator of early and systemic recurrence after surgical resection in pancreatic ductal adenocarcinoma10.1038/s41598-020-80383-12045-2322https://doaj.org/article/4b331bd32c6c421d861ccfd8231336f22021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80383-1https://doaj.org/toc/2045-2322Abstract Early recurrence in pancreatic ductal adenocarcinoma (PDAC) is a decisive factor in determining a patient's prognosis. We determined in our current study whether circulating tumour cells (CTCs) exist in the blood of PDAC patients and can be used as a predictor of recurrence patterns (i.e. time and site) after surgical resection. Between December 2017 and November 2018, the mononuclear cell layer was obtained from the peripheral blood of 36 patients diagnosed with PDAC. CTCs were then isolated using the CD-PRIME™ platform and detected via immunostaining. The patient records were analyzed to correlate these data with survival and recurrence patterns. Twelve patients were CTC-positive (33.3%) and showed a significantly frequent rate of systemic recurrence (distant metastases and peritoneal dissemination) (p = 0.025). On multi-variable logistic regression analysis, CTC positivity was an independent risk factor for early recurrence (p = 0.027) and for systemic recurrence (p = 0.033). In summary, the presence or absence of CTC in the blood of the patients with PDAC could help predict the recurrence pattern after surgery. PDAC patients with CTC positivity at tumour diagnosis should therefore undergo a comprehensive strategy for systemic therapy and active monitoring to detect possible early recurrence.Yejong ParkHye Ryeong JunHwi Wan ChoiDae Wook HwangJae Hoon LeeKi Byung SongWoohyung LeeJaewoo KwonSu Hyeon HaEunsung JunSong Cheol KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yejong Park Hye Ryeong Jun Hwi Wan Choi Dae Wook Hwang Jae Hoon Lee Ki Byung Song Woohyung Lee Jaewoo Kwon Su Hyeon Ha Eunsung Jun Song Cheol Kim Circulating tumour cells as an indicator of early and systemic recurrence after surgical resection in pancreatic ductal adenocarcinoma
description	Abstract Early recurrence in pancreatic ductal adenocarcinoma (PDAC) is a decisive factor in determining a patient's prognosis. We determined in our current study whether circulating tumour cells (CTCs) exist in the blood of PDAC patients and can be used as a predictor of recurrence patterns (i.e. time and site) after surgical resection. Between December 2017 and November 2018, the mononuclear cell layer was obtained from the peripheral blood of 36 patients diagnosed with PDAC. CTCs were then isolated using the CD-PRIME™ platform and detected via immunostaining. The patient records were analyzed to correlate these data with survival and recurrence patterns. Twelve patients were CTC-positive (33.3%) and showed a significantly frequent rate of systemic recurrence (distant metastases and peritoneal dissemination) (p = 0.025). On multi-variable logistic regression analysis, CTC positivity was an independent risk factor for early recurrence (p = 0.027) and for systemic recurrence (p = 0.033). In summary, the presence or absence of CTC in the blood of the patients with PDAC could help predict the recurrence pattern after surgery. PDAC patients with CTC positivity at tumour diagnosis should therefore undergo a comprehensive strategy for systemic therapy and active monitoring to detect possible early recurrence.
format	article
author	Yejong Park Hye Ryeong Jun Hwi Wan Choi Dae Wook Hwang Jae Hoon Lee Ki Byung Song Woohyung Lee Jaewoo Kwon Su Hyeon Ha Eunsung Jun Song Cheol Kim
author_facet	Yejong Park Hye Ryeong Jun Hwi Wan Choi Dae Wook Hwang Jae Hoon Lee Ki Byung Song Woohyung Lee Jaewoo Kwon Su Hyeon Ha Eunsung Jun Song Cheol Kim
author_sort	Yejong Park
title	Circulating tumour cells as an indicator of early and systemic recurrence after surgical resection in pancreatic ductal adenocarcinoma
title_short	Circulating tumour cells as an indicator of early and systemic recurrence after surgical resection in pancreatic ductal adenocarcinoma
title_full	Circulating tumour cells as an indicator of early and systemic recurrence after surgical resection in pancreatic ductal adenocarcinoma
title_fullStr	Circulating tumour cells as an indicator of early and systemic recurrence after surgical resection in pancreatic ductal adenocarcinoma
title_full_unstemmed	Circulating tumour cells as an indicator of early and systemic recurrence after surgical resection in pancreatic ductal adenocarcinoma
title_sort	circulating tumour cells as an indicator of early and systemic recurrence after surgical resection in pancreatic ductal adenocarcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4b331bd32c6c421d861ccfd8231336f2
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Circulating tumour cells as an indicator of early and systemic recurrence after surgical resection in pancreatic ductal adenocarcinoma

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