<italic toggle="yes">Campylobacter</italic> Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study

ABSTRACT Campylobacter jejuni is a leading cause of bacterial diarrhea worldwide and is associated with high rates of mortality and growth stunting in children inhabiting low- to middle-resource countries. To better understand the impact of breastfeeding on Campylobacter infection in infants in sub-...

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Autores principales:	Xiaoming Bian, Jolene M. Garber, Kerry K. Cooper, Steven Huynh, Jennifer Jones, Michael K. Mills, Daniel Rafala, Dilruba Nasrin, Karen L. Kotloff, Craig T. Parker, Sharon M. Tennant, William G. Miller, Christine M. Szymanski
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Campylobacter breastfeeding GEMS l-fucose metabolism “Candidatus Campylobacter infans,” gut microbiome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4b36dc2e6c2e41a29f5aff605ab1c0f4
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spelling	oai:doaj.org-article:4b36dc2e6c2e41a29f5aff605ab1c0f42021-11-15T15:27:53Z<italic toggle="yes">Campylobacter</italic> Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study10.1128/mSphere.00735-192379-5042https://doaj.org/article/4b36dc2e6c2e41a29f5aff605ab1c0f42020-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00735-19https://doaj.org/toc/2379-5042ABSTRACT Campylobacter jejuni is a leading cause of bacterial diarrhea worldwide and is associated with high rates of mortality and growth stunting in children inhabiting low- to middle-resource countries. To better understand the impact of breastfeeding on Campylobacter infection in infants in sub-Saharan Africa and South Asia, we examined fecal microbial compositions, bacterial isolates, and their carbohydrate metabolic pathways in Campylobacter-positive infants <1 year of age from the Global Enterics Multicenter Study. Exclusively breastfed infants with diarrhea exhibited high Campylobacter abundances, and this negatively correlated with bacterial carbohydrate metabolism. Although C. jejuni and Campylobacter coli are prevalent among these infants, the second most abundant Campylobacter species was a new species, which we named “Candidatus Campylobacter infans.” Asymptomatic Campylobacter carriers also possess significantly different proportions of specific gut microbes compared to diarrheal cases. These findings provide insight into Campylobacter infections in infants in sub-Saharan Africa and South Asia and help inform strategies aimed at eliminating campylobacteriosis in these areas. IMPORTANCE Campylobacter is the primary cause of bacterial diarrhea in the United States and can lead to the development of the postinfectious autoimmune neuropathy known as Guillain-Barré syndrome. Also, drug-resistant campylobacters are becoming a serious concern both locally and abroad. In low- and middle-income countries (LMICs), infection with Campylobacter is linked to high rates of morbidity, growth stunting, and mortality in children, and breastfeeding is important for infant nutrition, development, and protection against infectious diseases. In this study, we examined the relationship between breastfeeding and Campylobacter infection and demonstrate the increased selection for C. jejuni and C. coli strains unable to metabolize fucose. We also identify a new Campylobacter species coinfecting these infants with a high prevalence in five of the seven countries in sub-Saharan Africa and South Asia examined. These findings indicate that more detailed studies are needed in LMICs to understand the Campylobacter infection process in order to devise a strategy for eliminating this pathogenic microbe.Xiaoming BianJolene M. GarberKerry K. CooperSteven HuynhJennifer JonesMichael K. MillsDaniel RafalaDilruba NasrinKaren L. KotloffCraig T. ParkerSharon M. TennantWilliam G. MillerChristine M. SzymanskiAmerican Society for MicrobiologyarticleCampylobacterbreastfeedingGEMSl-fucose metabolism“Candidatus Campylobacter infans,” gut microbiomeMicrobiologyQR1-502ENmSphere, Vol 5, Iss 1 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Campylobacter breastfeeding GEMS l-fucose metabolism “Candidatus Campylobacter infans,” gut microbiome Microbiology QR1-502
spellingShingle	Campylobacter breastfeeding GEMS l-fucose metabolism “Candidatus Campylobacter infans,” gut microbiome Microbiology QR1-502 Xiaoming Bian Jolene M. Garber Kerry K. Cooper Steven Huynh Jennifer Jones Michael K. Mills Daniel Rafala Dilruba Nasrin Karen L. Kotloff Craig T. Parker Sharon M. Tennant William G. Miller Christine M. Szymanski <italic toggle="yes">Campylobacter</italic> Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study
description	ABSTRACT Campylobacter jejuni is a leading cause of bacterial diarrhea worldwide and is associated with high rates of mortality and growth stunting in children inhabiting low- to middle-resource countries. To better understand the impact of breastfeeding on Campylobacter infection in infants in sub-Saharan Africa and South Asia, we examined fecal microbial compositions, bacterial isolates, and their carbohydrate metabolic pathways in Campylobacter-positive infants <1 year of age from the Global Enterics Multicenter Study. Exclusively breastfed infants with diarrhea exhibited high Campylobacter abundances, and this negatively correlated with bacterial carbohydrate metabolism. Although C. jejuni and Campylobacter coli are prevalent among these infants, the second most abundant Campylobacter species was a new species, which we named “Candidatus Campylobacter infans.” Asymptomatic Campylobacter carriers also possess significantly different proportions of specific gut microbes compared to diarrheal cases. These findings provide insight into Campylobacter infections in infants in sub-Saharan Africa and South Asia and help inform strategies aimed at eliminating campylobacteriosis in these areas. IMPORTANCE Campylobacter is the primary cause of bacterial diarrhea in the United States and can lead to the development of the postinfectious autoimmune neuropathy known as Guillain-Barré syndrome. Also, drug-resistant campylobacters are becoming a serious concern both locally and abroad. In low- and middle-income countries (LMICs), infection with Campylobacter is linked to high rates of morbidity, growth stunting, and mortality in children, and breastfeeding is important for infant nutrition, development, and protection against infectious diseases. In this study, we examined the relationship between breastfeeding and Campylobacter infection and demonstrate the increased selection for C. jejuni and C. coli strains unable to metabolize fucose. We also identify a new Campylobacter species coinfecting these infants with a high prevalence in five of the seven countries in sub-Saharan Africa and South Asia examined. These findings indicate that more detailed studies are needed in LMICs to understand the Campylobacter infection process in order to devise a strategy for eliminating this pathogenic microbe.
format	article
author	Xiaoming Bian Jolene M. Garber Kerry K. Cooper Steven Huynh Jennifer Jones Michael K. Mills Daniel Rafala Dilruba Nasrin Karen L. Kotloff Craig T. Parker Sharon M. Tennant William G. Miller Christine M. Szymanski
author_facet	Xiaoming Bian Jolene M. Garber Kerry K. Cooper Steven Huynh Jennifer Jones Michael K. Mills Daniel Rafala Dilruba Nasrin Karen L. Kotloff Craig T. Parker Sharon M. Tennant William G. Miller Christine M. Szymanski
author_sort	Xiaoming Bian
title	<italic toggle="yes">Campylobacter</italic> Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study
title_short	<italic toggle="yes">Campylobacter</italic> Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study
title_full	<italic toggle="yes">Campylobacter</italic> Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study
title_fullStr	<italic toggle="yes">Campylobacter</italic> Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study
title_full_unstemmed	<italic toggle="yes">Campylobacter</italic> Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study
title_sort	<italic toggle="yes">campylobacter</italic> abundance in breastfed infants and identification of a new species in the global enterics multicenter study
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/4b36dc2e6c2e41a29f5aff605ab1c0f4
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<italic toggle="yes">Campylobacter</italic> Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study

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