Dysregulated gene-associated biomarkers for Alzheimer’s disease and aging

Alzheimer’s disease (AD), the most common type of dementia, is a neurodegenerative disorder with a hidden onset, including difficult early detection and diagnosis. Nevertheless, the new crucial biomarkers for the diagnosis and pathogenesis of AD need to be explored further. Here, the common differen...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Li Min, Geng Rongxin, Li Chen, Meng Fantao, Zhao Hongwei, Liu Jing, Dai Juanjuan, Wang Xuezhen
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	alzheimer’s disease aging differentially expressed genes blood hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/4b37915e664840cb8a47b0212ab8fdbd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4b37915e664840cb8a47b0212ab8fdbd
record_format	dspace
spelling	oai:doaj.org-article:4b37915e664840cb8a47b0212ab8fdbd2021-12-05T14:11:05ZDysregulated gene-associated biomarkers for Alzheimer’s disease and aging2081-693610.1515/tnsci-2021-0009https://doaj.org/article/4b37915e664840cb8a47b0212ab8fdbd2021-02-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2021-0009https://doaj.org/toc/2081-6936Alzheimer’s disease (AD), the most common type of dementia, is a neurodegenerative disorder with a hidden onset, including difficult early detection and diagnosis. Nevertheless, the new crucial biomarkers for the diagnosis and pathogenesis of AD need to be explored further. Here, the common differentially expressed genes (DEGs) were identified through a comprehensive analysis of gene expression profiles from the Gene Expression Omnibus (GEO) database. Furthermore, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses revealed that these DEGs were mainly associated with biological processes, cellular components, and molecular functions, which are involved in multiple cellular functions. Next, we found that 9 of the 24 genes showed the same regulatory changes in the blood of patients with AD compared to those in the GEO database, and 2 of the 24 genes showed a significant correlation with Montreal Cognitive Assessment scores. Finally, we determined that mice with AD and elderly mice had the same regulatory changes in the identified DEGs in both the blood and hippocampus. Our study identified several potential core biomarkers of AD and aging, which could contribute to the early detection, differential diagnosis, treatment, and pathological analysis of AD.Li MinGeng RongxinLi ChenMeng FantaoZhao HongweiLiu JingDai JuanjuanWang XuezhenDe Gruyterarticlealzheimer’s diseaseagingdifferentially expressed genesbloodhippocampusNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 12, Iss 1, Pp 83-95 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alzheimer’s disease aging differentially expressed genes blood hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	alzheimer’s disease aging differentially expressed genes blood hippocampus Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Li Min Geng Rongxin Li Chen Meng Fantao Zhao Hongwei Liu Jing Dai Juanjuan Wang Xuezhen Dysregulated gene-associated biomarkers for Alzheimer’s disease and aging
description	Alzheimer’s disease (AD), the most common type of dementia, is a neurodegenerative disorder with a hidden onset, including difficult early detection and diagnosis. Nevertheless, the new crucial biomarkers for the diagnosis and pathogenesis of AD need to be explored further. Here, the common differentially expressed genes (DEGs) were identified through a comprehensive analysis of gene expression profiles from the Gene Expression Omnibus (GEO) database. Furthermore, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses revealed that these DEGs were mainly associated with biological processes, cellular components, and molecular functions, which are involved in multiple cellular functions. Next, we found that 9 of the 24 genes showed the same regulatory changes in the blood of patients with AD compared to those in the GEO database, and 2 of the 24 genes showed a significant correlation with Montreal Cognitive Assessment scores. Finally, we determined that mice with AD and elderly mice had the same regulatory changes in the identified DEGs in both the blood and hippocampus. Our study identified several potential core biomarkers of AD and aging, which could contribute to the early detection, differential diagnosis, treatment, and pathological analysis of AD.
format	article
author	Li Min Geng Rongxin Li Chen Meng Fantao Zhao Hongwei Liu Jing Dai Juanjuan Wang Xuezhen
author_facet	Li Min Geng Rongxin Li Chen Meng Fantao Zhao Hongwei Liu Jing Dai Juanjuan Wang Xuezhen
author_sort	Li Min
title	Dysregulated gene-associated biomarkers for Alzheimer’s disease and aging
title_short	Dysregulated gene-associated biomarkers for Alzheimer’s disease and aging
title_full	Dysregulated gene-associated biomarkers for Alzheimer’s disease and aging
title_fullStr	Dysregulated gene-associated biomarkers for Alzheimer’s disease and aging
title_full_unstemmed	Dysregulated gene-associated biomarkers for Alzheimer’s disease and aging
title_sort	dysregulated gene-associated biomarkers for alzheimer’s disease and aging
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/4b37915e664840cb8a47b0212ab8fdbd
work_keys_str_mv	AT limin dysregulatedgeneassociatedbiomarkersforalzheimersdiseaseandaging AT gengrongxin dysregulatedgeneassociatedbiomarkersforalzheimersdiseaseandaging AT lichen dysregulatedgeneassociatedbiomarkersforalzheimersdiseaseandaging AT mengfantao dysregulatedgeneassociatedbiomarkersforalzheimersdiseaseandaging AT zhaohongwei dysregulatedgeneassociatedbiomarkersforalzheimersdiseaseandaging AT liujing dysregulatedgeneassociatedbiomarkersforalzheimersdiseaseandaging AT daijuanjuan dysregulatedgeneassociatedbiomarkersforalzheimersdiseaseandaging AT wangxuezhen dysregulatedgeneassociatedbiomarkersforalzheimersdiseaseandaging
_version_	1718371418626850816

Dysregulated gene-associated biomarkers for Alzheimer’s disease and aging

Ejemplares similares