Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China

Abstract Optimization of skin prick test (SPT) panels, especially in view of significant differences in sensitizations patterns within different geographical areas, is an unmet need within China. Our aim was to assess the patterns and clinical relevance of aeroallergen sensitizations in allergic rhi...

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Autores principales:	Hongfei Lou, Siyuan Ma, Yan Zhao, Feifei Cao, Fei He, Zhongyan Liu, Jean Bousquet, Chengshuo Wang, Luo Zhang, Claus Bachert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b3b1e0ff68b46fab5ba3c221d730a05
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spelling	oai:doaj.org-article:4b3b1e0ff68b46fab5ba3c221d730a052021-12-02T15:05:34ZSensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China10.1038/s41598-017-10111-92045-2322https://doaj.org/article/4b3b1e0ff68b46fab5ba3c221d730a052017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-10111-9https://doaj.org/toc/2045-2322Abstract Optimization of skin prick test (SPT) panels, especially in view of significant differences in sensitizations patterns within different geographical areas, is an unmet need within China. Our aim was to assess the patterns and clinical relevance of aeroallergen sensitizations in allergic rhinitis (AR) and define the minimal battery of SPT allergens, classified according to the Köppen-Geiger climate map. Overall, 7148 subjects with self-reported AR completed a standard questionnaire and were assessed for sensitization to relevant allergens by SPT. 6340 (88.7%) patients had at least one positive skin prick reaction, and demonstrated unique sensitization patterns by stratification with age, gender, and geographic region. Sensitization to house dust mites (HDM) was highest in south China, whereas the three most prevalent aeroallergens were mugwort, ragweed and dandelion pollen in north-west China. Higher sensitization rates and multiple sensitizations were associated with AR comorbidities. Eight allergens (Der f, mugwort, Blatella, hazel, goosefoot, Penicillium notatum, animal dander and Der p) allowed identification >96% of sensitized subjects in central China. Differences in optimal panels were observed between regions, with five to six allergens being sufficient for north-east, north-west and south China. These SPT panels may provide a cost-effective tool for screening sensitized patients in China.Hongfei LouSiyuan MaYan ZhaoFeifei CaoFei HeZhongyan LiuJean BousquetChengshuo WangLuo ZhangClaus BachertNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hongfei Lou Siyuan Ma Yan Zhao Feifei Cao Fei He Zhongyan Liu Jean Bousquet Chengshuo Wang Luo Zhang Claus Bachert Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China
description	Abstract Optimization of skin prick test (SPT) panels, especially in view of significant differences in sensitizations patterns within different geographical areas, is an unmet need within China. Our aim was to assess the patterns and clinical relevance of aeroallergen sensitizations in allergic rhinitis (AR) and define the minimal battery of SPT allergens, classified according to the Köppen-Geiger climate map. Overall, 7148 subjects with self-reported AR completed a standard questionnaire and were assessed for sensitization to relevant allergens by SPT. 6340 (88.7%) patients had at least one positive skin prick reaction, and demonstrated unique sensitization patterns by stratification with age, gender, and geographic region. Sensitization to house dust mites (HDM) was highest in south China, whereas the three most prevalent aeroallergens were mugwort, ragweed and dandelion pollen in north-west China. Higher sensitization rates and multiple sensitizations were associated with AR comorbidities. Eight allergens (Der f, mugwort, Blatella, hazel, goosefoot, Penicillium notatum, animal dander and Der p) allowed identification >96% of sensitized subjects in central China. Differences in optimal panels were observed between regions, with five to six allergens being sufficient for north-east, north-west and south China. These SPT panels may provide a cost-effective tool for screening sensitized patients in China.
format	article
author	Hongfei Lou Siyuan Ma Yan Zhao Feifei Cao Fei He Zhongyan Liu Jean Bousquet Chengshuo Wang Luo Zhang Claus Bachert
author_facet	Hongfei Lou Siyuan Ma Yan Zhao Feifei Cao Fei He Zhongyan Liu Jean Bousquet Chengshuo Wang Luo Zhang Claus Bachert
author_sort	Hongfei Lou
title	Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China
title_short	Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China
title_full	Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China
title_fullStr	Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China
title_full_unstemmed	Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China
title_sort	sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in china
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4b3b1e0ff68b46fab5ba3c221d730a05
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Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China

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