Ozone inactivation of airborne influenza and lack of resistance of respiratory syncytial virus to aerosolization and sampling processes.

Influenza and RSV are human viruses responsible for outbreaks in hospitals, long-term care facilities and nursing homes. The present study assessed an air treatment using ozone at two relative humidity conditions (RHs) in order to reduce the infectivity of airborne influenza. Bovine pulmonary surfac...

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Autores principales:	Marie-Eve Dubuis, Étienne Racine, Jonathan M Vyskocil, Nathalie Turgeon, Christophe Tremblay, Espérance Mukawera, Guy Boivin, Nathalie Grandvaux, Caroline Duchaine
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b3bfdce9a4a4351b08e611d25614cf2
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spelling	oai:doaj.org-article:4b3bfdce9a4a4351b08e611d25614cf22021-12-02T20:05:06ZOzone inactivation of airborne influenza and lack of resistance of respiratory syncytial virus to aerosolization and sampling processes.1932-620310.1371/journal.pone.0253022https://doaj.org/article/4b3bfdce9a4a4351b08e611d25614cf22021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253022https://doaj.org/toc/1932-6203Influenza and RSV are human viruses responsible for outbreaks in hospitals, long-term care facilities and nursing homes. The present study assessed an air treatment using ozone at two relative humidity conditions (RHs) in order to reduce the infectivity of airborne influenza. Bovine pulmonary surfactant (BPS) and synthetic tracheal mucus (STM) were used as aerosols protectants to better reflect the human aerosol composition. Residual ozone concentration inside the aerosol chamber was also measured. RSV's sensitivity resulted in testing its resistance to aerosolization and sampling processes instead of ozone exposure. The results showed that without supplement and with STM, a reduction in influenza A infectivity of four orders of magnitude was obtained with an exposure to 1.70 ± 0.19 ppm of ozone at 76% RH for 80 min. Consequently, ozone could be considered as a virucidal disinfectant for airborne influenza A. RSV did not withstand the aerosolization and sampling processes required for the use of the experimental setup. Therefore, ozone exposure could not be performed for this virus. Nonetheless, this study provides great insight for the efficacy of ozone as an air treatment for the control of nosocomial influenza A outbreaks.Marie-Eve DubuisÉtienne RacineJonathan M VyskocilNathalie TurgeonChristophe TremblayEspérance MukaweraGuy BoivinNathalie GrandvauxCaroline DuchainePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253022 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie-Eve Dubuis Étienne Racine Jonathan M Vyskocil Nathalie Turgeon Christophe Tremblay Espérance Mukawera Guy Boivin Nathalie Grandvaux Caroline Duchaine Ozone inactivation of airborne influenza and lack of resistance of respiratory syncytial virus to aerosolization and sampling processes.
description	Influenza and RSV are human viruses responsible for outbreaks in hospitals, long-term care facilities and nursing homes. The present study assessed an air treatment using ozone at two relative humidity conditions (RHs) in order to reduce the infectivity of airborne influenza. Bovine pulmonary surfactant (BPS) and synthetic tracheal mucus (STM) were used as aerosols protectants to better reflect the human aerosol composition. Residual ozone concentration inside the aerosol chamber was also measured. RSV's sensitivity resulted in testing its resistance to aerosolization and sampling processes instead of ozone exposure. The results showed that without supplement and with STM, a reduction in influenza A infectivity of four orders of magnitude was obtained with an exposure to 1.70 ± 0.19 ppm of ozone at 76% RH for 80 min. Consequently, ozone could be considered as a virucidal disinfectant for airborne influenza A. RSV did not withstand the aerosolization and sampling processes required for the use of the experimental setup. Therefore, ozone exposure could not be performed for this virus. Nonetheless, this study provides great insight for the efficacy of ozone as an air treatment for the control of nosocomial influenza A outbreaks.
format	article
author	Marie-Eve Dubuis Étienne Racine Jonathan M Vyskocil Nathalie Turgeon Christophe Tremblay Espérance Mukawera Guy Boivin Nathalie Grandvaux Caroline Duchaine
author_facet	Marie-Eve Dubuis Étienne Racine Jonathan M Vyskocil Nathalie Turgeon Christophe Tremblay Espérance Mukawera Guy Boivin Nathalie Grandvaux Caroline Duchaine
author_sort	Marie-Eve Dubuis
title	Ozone inactivation of airborne influenza and lack of resistance of respiratory syncytial virus to aerosolization and sampling processes.
title_short	Ozone inactivation of airborne influenza and lack of resistance of respiratory syncytial virus to aerosolization and sampling processes.
title_full	Ozone inactivation of airborne influenza and lack of resistance of respiratory syncytial virus to aerosolization and sampling processes.
title_fullStr	Ozone inactivation of airborne influenza and lack of resistance of respiratory syncytial virus to aerosolization and sampling processes.
title_full_unstemmed	Ozone inactivation of airborne influenza and lack of resistance of respiratory syncytial virus to aerosolization and sampling processes.
title_sort	ozone inactivation of airborne influenza and lack of resistance of respiratory syncytial virus to aerosolization and sampling processes.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/4b3bfdce9a4a4351b08e611d25614cf2
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Ozone inactivation of airborne influenza and lack of resistance of respiratory syncytial virus to aerosolization and sampling processes.

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