Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments

Chronic stress is common among cancer patients due to the psychological, operative, or pharmaceutical stressors at the time of diagnosis or during the treatment of cancers. The continuous activations of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS), as result...

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Autores principales:	Wentao Tian, Yi Liu, Chenghui Cao, Yue Zeng, Yue Pan, Xiaohan Liu, Yurong Peng, Fang Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	chronic stress tumor microenvironment glucocorticoid catecholamine anticancer treatment Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4b413687b2cf4b6fb1b2746406af0d90
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spelling	oai:doaj.org-article:4b413687b2cf4b6fb1b2746406af0d902021-11-19T07:36:38ZChronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments2296-634X10.3389/fcell.2021.777018https://doaj.org/article/4b413687b2cf4b6fb1b2746406af0d902021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.777018/fullhttps://doaj.org/toc/2296-634XChronic stress is common among cancer patients due to the psychological, operative, or pharmaceutical stressors at the time of diagnosis or during the treatment of cancers. The continuous activations of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS), as results of chronic stress, have been demonstrated to take part in several cancer-promoting processes, such as tumorigenesis, progression, metastasis, and multi-drug resistance, by altering the tumor microenvironment (TME). Stressed TME is generally characterized by the increased proportion of cancer-promoting cells and cytokines, the reduction and malfunction of immune-supportive cells and cytokines, augmented angiogenesis, enhanced epithelial-mesenchymal transition, and damaged extracellular matrix. For the negative effects that these alterations can cause in terms of the efficacies of anti-cancer treatments and prognosis of patients, supplementary pharmacological or psychotherapeutic strategies targeting HPA, SNS, or psychological stress may be effective in improving the prognosis of cancer patients. Here, we review the characteristics and mechanisms of TME alterations under chronic stress, their influences on anti-cancer therapies, and accessory interventions and therapies for stressed cancer patients.Wentao TianWentao TianYi LiuChenghui CaoChenghui CaoYue ZengYue PanXiaohan LiuYurong PengFang WuFang WuFang WuFang WuFrontiers Media S.A.articlechronic stresstumor microenvironmentglucocorticoidcatecholamineanticancer treatmentBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic stress tumor microenvironment glucocorticoid catecholamine anticancer treatment Biology (General) QH301-705.5
spellingShingle	chronic stress tumor microenvironment glucocorticoid catecholamine anticancer treatment Biology (General) QH301-705.5 Wentao Tian Wentao Tian Yi Liu Chenghui Cao Chenghui Cao Yue Zeng Yue Pan Xiaohan Liu Yurong Peng Fang Wu Fang Wu Fang Wu Fang Wu Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments
description	Chronic stress is common among cancer patients due to the psychological, operative, or pharmaceutical stressors at the time of diagnosis or during the treatment of cancers. The continuous activations of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS), as results of chronic stress, have been demonstrated to take part in several cancer-promoting processes, such as tumorigenesis, progression, metastasis, and multi-drug resistance, by altering the tumor microenvironment (TME). Stressed TME is generally characterized by the increased proportion of cancer-promoting cells and cytokines, the reduction and malfunction of immune-supportive cells and cytokines, augmented angiogenesis, enhanced epithelial-mesenchymal transition, and damaged extracellular matrix. For the negative effects that these alterations can cause in terms of the efficacies of anti-cancer treatments and prognosis of patients, supplementary pharmacological or psychotherapeutic strategies targeting HPA, SNS, or psychological stress may be effective in improving the prognosis of cancer patients. Here, we review the characteristics and mechanisms of TME alterations under chronic stress, their influences on anti-cancer therapies, and accessory interventions and therapies for stressed cancer patients.
format	article
author	Wentao Tian Wentao Tian Yi Liu Chenghui Cao Chenghui Cao Yue Zeng Yue Pan Xiaohan Liu Yurong Peng Fang Wu Fang Wu Fang Wu Fang Wu
author_facet	Wentao Tian Wentao Tian Yi Liu Chenghui Cao Chenghui Cao Yue Zeng Yue Pan Xiaohan Liu Yurong Peng Fang Wu Fang Wu Fang Wu Fang Wu
author_sort	Wentao Tian
title	Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments
title_short	Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments
title_full	Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments
title_fullStr	Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments
title_full_unstemmed	Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments
title_sort	chronic stress: impacts on tumor microenvironment and implications for anti-cancer treatments
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4b413687b2cf4b6fb1b2746406af0d90
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Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments

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