Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles

Michael Galagudza1, Dmitry Korolev1, Viktor Postnov2, Elena Naumisheva2, Yulia Grigorova3, Ivan Uskov1, Eugene Shlyakhto11Institute of Experimental Medicine, VA Almazov Federal Heart, Blood and Endocrinology Center, 2Chemical Faculty, St Petersburg State University, 3Department of Pathophysiology, I...

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Autores principales:	Galagudza M, Korolev D, Postnov V, Naumisheva E, Grigorova Y, Uskov I, Shlyakhto E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4b42193101044c4a9a1612ce2e7ca76b
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spelling	oai:doaj.org-article:4b42193101044c4a9a1612ce2e7ca76b2021-12-02T07:21:16ZPassive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles1176-91141178-2013https://doaj.org/article/4b42193101044c4a9a1612ce2e7ca76b2012-04-01T00:00:00Zhttp://www.dovepress.com/passive-targeting-of-ischemic-reperfused-myocardium-with-adenosine-loa-a9694https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Michael Galagudza1, Dmitry Korolev1, Viktor Postnov2, Elena Naumisheva2, Yulia Grigorova3, Ivan Uskov1, Eugene Shlyakhto11Institute of Experimental Medicine, VA Almazov Federal Heart, Blood and Endocrinology Center, 2Chemical Faculty, St Petersburg State University, 3Department of Pathophysiology, IP Pavlov State Medical University, St Petersburg, Russian FederationAbstract: Pharmacological agents suggested for infarct size limitation have serious side effects when used at cardioprotective doses which hinders their translation into clinical practice. The solution to the problem might be direct delivery of cardioprotective drugs into ischemic-reperfused myocardium. In this study, we explored the potential of silica nanoparticles for passive delivery of adenosine, a prototype cardioprotective agent, into ischemic-reperfused heart tissue. In addition, the biodegradation of silica nanoparticles was studied both in vitro and in vivo. Immobilization of adenosine on the surface of silica nanoparticles resulted in enhancement of adenosine-mediated infarct size limitation in the rat model. Furthermore, the hypotensive effect of adenosine was attenuated after its adsorption on silica nanoparticles. We conclude that silica nanoparticles are biocompatible materials that might potentially be used as carriers for heart-targeted drug delivery.Keywords: silica nanoparticles, targeted drug delivery, myocardium, ischemia, reperfusionGalagudza MKorolev DPostnov VNaumisheva EGrigorova YUskov IShlyakhto EDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 1671-1678 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Galagudza M Korolev D Postnov V Naumisheva E Grigorova Y Uskov I Shlyakhto E Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles
description	Michael Galagudza1, Dmitry Korolev1, Viktor Postnov2, Elena Naumisheva2, Yulia Grigorova3, Ivan Uskov1, Eugene Shlyakhto11Institute of Experimental Medicine, VA Almazov Federal Heart, Blood and Endocrinology Center, 2Chemical Faculty, St Petersburg State University, 3Department of Pathophysiology, IP Pavlov State Medical University, St Petersburg, Russian FederationAbstract: Pharmacological agents suggested for infarct size limitation have serious side effects when used at cardioprotective doses which hinders their translation into clinical practice. The solution to the problem might be direct delivery of cardioprotective drugs into ischemic-reperfused myocardium. In this study, we explored the potential of silica nanoparticles for passive delivery of adenosine, a prototype cardioprotective agent, into ischemic-reperfused heart tissue. In addition, the biodegradation of silica nanoparticles was studied both in vitro and in vivo. Immobilization of adenosine on the surface of silica nanoparticles resulted in enhancement of adenosine-mediated infarct size limitation in the rat model. Furthermore, the hypotensive effect of adenosine was attenuated after its adsorption on silica nanoparticles. We conclude that silica nanoparticles are biocompatible materials that might potentially be used as carriers for heart-targeted drug delivery.Keywords: silica nanoparticles, targeted drug delivery, myocardium, ischemia, reperfusion
format	article
author	Galagudza M Korolev D Postnov V Naumisheva E Grigorova Y Uskov I Shlyakhto E
author_facet	Galagudza M Korolev D Postnov V Naumisheva E Grigorova Y Uskov I Shlyakhto E
author_sort	Galagudza M
title	Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles
title_short	Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles
title_full	Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles
title_fullStr	Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles
title_full_unstemmed	Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles
title_sort	passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/4b42193101044c4a9a1612ce2e7ca76b
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Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles

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