Implication of FDG-PET/CT without synchronous colonic lesion in patients with stenotic left-sided colorectal cancer

Abstract Although 18-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) is useful for detecting synchronous colorectal cancer (CRC) in stenotic CRC, long-term outcomes of patients without synchronous FDG-avid lesions are not well reported. We investigated postop...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jong Il Lee, Sang Sik Cho, Ui Sup Shin, Byong Ho Jeon, Sun Mi Moon, Younjoo Kim, Ki Young Yang, Byung Il Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b439ce88cb943939613857a030a2f70
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4b439ce88cb943939613857a030a2f70
record_format	dspace
spelling	oai:doaj.org-article:4b439ce88cb943939613857a030a2f702021-12-02T16:50:24ZImplication of FDG-PET/CT without synchronous colonic lesion in patients with stenotic left-sided colorectal cancer10.1038/s41598-021-94030-w2045-2322https://doaj.org/article/4b439ce88cb943939613857a030a2f702021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94030-whttps://doaj.org/toc/2045-2322Abstract Although 18-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) is useful for detecting synchronous colorectal cancer (CRC) in stenotic CRC, long-term outcomes of patients without synchronous FDG-avid lesions are not well reported. We investigated postoperative colonoscopy results in patients with left-sided stenosing CRC without synchronous FDG-avid lesions. In this retrospective review, 754 patients with left-sided CRC without synchronous FDG-avid lesions on preoperative 18F-FDG PET/CT were divided into two groups based on the completeness of preoperative colonoscopy. Propensity score matching was performed to balance baseline characteristics. Results of postoperative colonoscopy were compared in both the unmatched and matched cohorts. At 1 and 5 years after surgery, the cumulative risk of advanced adenoma (AA) or carcinoma (CA) in all patients, risk of CA, and additional surgical risk were 1.8% and 10.1%, 0.1% and 0.4%, and 0% and 0.5%, respectively. In both cohorts, the AA risk was significantly higher in the incomplete colonoscopy group. However, the risk of CA showed no between-group difference in the matched cohort. Additional surgical risk did not differ between the two groups. Thus, the finding of negative FDG-avid lesions in the proximal colon in addition to the target CRC ensures the absence of additional lesions warranting surgical plan changes.Jong Il LeeSang Sik ChoUi Sup ShinByong Ho JeonSun Mi MoonYounjoo KimKi Young YangByung Il KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jong Il Lee Sang Sik Cho Ui Sup Shin Byong Ho Jeon Sun Mi Moon Younjoo Kim Ki Young Yang Byung Il Kim Implication of FDG-PET/CT without synchronous colonic lesion in patients with stenotic left-sided colorectal cancer
description	Abstract Although 18-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) is useful for detecting synchronous colorectal cancer (CRC) in stenotic CRC, long-term outcomes of patients without synchronous FDG-avid lesions are not well reported. We investigated postoperative colonoscopy results in patients with left-sided stenosing CRC without synchronous FDG-avid lesions. In this retrospective review, 754 patients with left-sided CRC without synchronous FDG-avid lesions on preoperative 18F-FDG PET/CT were divided into two groups based on the completeness of preoperative colonoscopy. Propensity score matching was performed to balance baseline characteristics. Results of postoperative colonoscopy were compared in both the unmatched and matched cohorts. At 1 and 5 years after surgery, the cumulative risk of advanced adenoma (AA) or carcinoma (CA) in all patients, risk of CA, and additional surgical risk were 1.8% and 10.1%, 0.1% and 0.4%, and 0% and 0.5%, respectively. In both cohorts, the AA risk was significantly higher in the incomplete colonoscopy group. However, the risk of CA showed no between-group difference in the matched cohort. Additional surgical risk did not differ between the two groups. Thus, the finding of negative FDG-avid lesions in the proximal colon in addition to the target CRC ensures the absence of additional lesions warranting surgical plan changes.
format	article
author	Jong Il Lee Sang Sik Cho Ui Sup Shin Byong Ho Jeon Sun Mi Moon Younjoo Kim Ki Young Yang Byung Il Kim
author_facet	Jong Il Lee Sang Sik Cho Ui Sup Shin Byong Ho Jeon Sun Mi Moon Younjoo Kim Ki Young Yang Byung Il Kim
author_sort	Jong Il Lee
title	Implication of FDG-PET/CT without synchronous colonic lesion in patients with stenotic left-sided colorectal cancer
title_short	Implication of FDG-PET/CT without synchronous colonic lesion in patients with stenotic left-sided colorectal cancer
title_full	Implication of FDG-PET/CT without synchronous colonic lesion in patients with stenotic left-sided colorectal cancer
title_fullStr	Implication of FDG-PET/CT without synchronous colonic lesion in patients with stenotic left-sided colorectal cancer
title_full_unstemmed	Implication of FDG-PET/CT without synchronous colonic lesion in patients with stenotic left-sided colorectal cancer
title_sort	implication of fdg-pet/ct without synchronous colonic lesion in patients with stenotic left-sided colorectal cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4b439ce88cb943939613857a030a2f70
work_keys_str_mv	AT jongillee implicationoffdgpetctwithoutsynchronouscoloniclesioninpatientswithstenoticleftsidedcolorectalcancer AT sangsikcho implicationoffdgpetctwithoutsynchronouscoloniclesioninpatientswithstenoticleftsidedcolorectalcancer AT uisupshin implicationoffdgpetctwithoutsynchronouscoloniclesioninpatientswithstenoticleftsidedcolorectalcancer AT byonghojeon implicationoffdgpetctwithoutsynchronouscoloniclesioninpatientswithstenoticleftsidedcolorectalcancer AT sunmimoon implicationoffdgpetctwithoutsynchronouscoloniclesioninpatientswithstenoticleftsidedcolorectalcancer AT younjookim implicationoffdgpetctwithoutsynchronouscoloniclesioninpatientswithstenoticleftsidedcolorectalcancer AT kiyoungyang implicationoffdgpetctwithoutsynchronouscoloniclesioninpatientswithstenoticleftsidedcolorectalcancer AT byungilkim implicationoffdgpetctwithoutsynchronouscoloniclesioninpatientswithstenoticleftsidedcolorectalcancer
_version_	1718383035246706688

Implication of FDG-PET/CT without synchronous colonic lesion in patients with stenotic left-sided colorectal cancer

Ejemplares similares