Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice

Sudharshan Reddy D1, Muchandi IS2, Srinivasa Rao A3, Pradeep HA1, Ravi Kumar K1, Srinivasa Rao M1, Mohammed Ibrahim11Nizam Institute of Pharmacy, Hyderabad, Andhra Pradesh, India; 2HSK College of Pharmacy, Bagalkot, Karnataka, India; 3Bhaskar College of Pharmacy, Hyderabad, Andhra Pradesh, IndiaAbst...

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Autor principal:	Ibrahim M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Holostemma annularis High fructose diet Anti-hyperglycaemic C57BL/6J ob/ob mice. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/4b45d4d4895e41ca9f30f3ea9f63be79
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spelling	oai:doaj.org-article:4b45d4d4895e41ca9f30f3ea9f63be792021-12-02T00:54:26ZEffect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice1178-7007https://doaj.org/article/4b45d4d4895e41ca9f30f3ea9f63be792010-04-01T00:00:00Zhttps://www.dovepress.com/effect-of-holostemma-annularis-on-the-progression-of-diabetes-induced--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Sudharshan Reddy D1, Muchandi IS2, Srinivasa Rao A3, Pradeep HA1, Ravi Kumar K1, Srinivasa Rao M1, Mohammed Ibrahim11Nizam Institute of Pharmacy, Hyderabad, Andhra Pradesh, India; 2HSK College of Pharmacy, Bagalkot, Karnataka, India; 3Bhaskar College of Pharmacy, Hyderabad, Andhra Pradesh, IndiaAbstract: The roots of Holostemma annularis K. Schum (Asclepiadacae) are used in traditional medicine to treat diabetes. This medicinal plant, widely used in more than 34 ayurvedic preparations, was evaluated in a high fructose diet in induced insulin resistance and in C57BL/6J ob/ob diabetic mice for its antidiabetic activity. Graded doses of both chloroform and methanolic extracts of the roots of H. annularis were administered to normal and experimental diabetic rats for 21 days. Serum glucose, triglycerides, cholesterol levels and total protein in urine were analyzed. Significant results were observed in the estimated parameters. These data justify the use of the plant in the treatment of diabetes mellitus and is a potential source for the isolation of new active agents for diabetes mellitus.Keywords: Holostemma annularis, high fructose diet, antihyperglycemic, C57BL/6J ob/ob miceIbrahim MDove Medical PressarticleHolostemma annularisHigh fructose dietAnti-hyperglycaemicC57BL/6J ob/ob mice.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 3, Pp 87-94 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Holostemma annularis High fructose diet Anti-hyperglycaemic C57BL/6J ob/ob mice. Specialties of internal medicine RC581-951
spellingShingle	Holostemma annularis High fructose diet Anti-hyperglycaemic C57BL/6J ob/ob mice. Specialties of internal medicine RC581-951 Ibrahim M Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice
description	Sudharshan Reddy D1, Muchandi IS2, Srinivasa Rao A3, Pradeep HA1, Ravi Kumar K1, Srinivasa Rao M1, Mohammed Ibrahim11Nizam Institute of Pharmacy, Hyderabad, Andhra Pradesh, India; 2HSK College of Pharmacy, Bagalkot, Karnataka, India; 3Bhaskar College of Pharmacy, Hyderabad, Andhra Pradesh, IndiaAbstract: The roots of Holostemma annularis K. Schum (Asclepiadacae) are used in traditional medicine to treat diabetes. This medicinal plant, widely used in more than 34 ayurvedic preparations, was evaluated in a high fructose diet in induced insulin resistance and in C57BL/6J ob/ob diabetic mice for its antidiabetic activity. Graded doses of both chloroform and methanolic extracts of the roots of H. annularis were administered to normal and experimental diabetic rats for 21 days. Serum glucose, triglycerides, cholesterol levels and total protein in urine were analyzed. Significant results were observed in the estimated parameters. These data justify the use of the plant in the treatment of diabetes mellitus and is a potential source for the isolation of new active agents for diabetes mellitus.Keywords: Holostemma annularis, high fructose diet, antihyperglycemic, C57BL/6J ob/ob mice
format	article
author	Ibrahim M
author_facet	Ibrahim M
author_sort	Ibrahim M
title	Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice
title_short	Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice
title_full	Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice
title_fullStr	Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice
title_full_unstemmed	Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice
title_sort	effect of holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic c57bl/6j ob/ob mice
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/4b45d4d4895e41ca9f30f3ea9f63be79
work_keys_str_mv	AT ibrahimm effectofholostemmaannularisontheprogressionofdiabetesinducedbyahighfructosedietinratsandindiabeticc57bl6jobobmice
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Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob mice

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