Associations between Circulating Inflammatory Biomarkers and Indicators of Muscle Health in Older Men and Women

Systemic inflammation is believed to contribute to declining muscle health during aging. The present study aims to examine associations between indicators of muscle health and pro- and anti-inflammatory biomarkers in older men and women, while also considering the impacts of physical activity and pr...

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Autores principales:	Oscar Bergens, Andreas Nilsson, Fawzi Kadi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	muscle mass muscle strength aging inflammatory biomarkers obesity protein intake Medicine R
Acceso en línea:	https://doaj.org/article/4b464062d47d4544b176728ad6f9162e
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spelling	oai:doaj.org-article:4b464062d47d4544b176728ad6f9162e2021-11-25T18:01:37ZAssociations between Circulating Inflammatory Biomarkers and Indicators of Muscle Health in Older Men and Women10.3390/jcm102253162077-0383https://doaj.org/article/4b464062d47d4544b176728ad6f9162e2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5316https://doaj.org/toc/2077-0383Systemic inflammation is believed to contribute to declining muscle health during aging. The present study aims to examine associations between indicators of muscle health and pro- and anti-inflammatory biomarkers in older men and women, while also considering the impacts of physical activity and protein intake. An assessment of skeletal muscle index (SMI) by bioelectrical impedance analysis, handgrip strength, and 5-sit-to-stand time, using standardized procedures, was conducted in a population of older men (<i>n</i> = 90) and women (<i>n</i> = 148) aged 65–70 years. The inflammatory biomarkers C-reactive protein (CRP), fibrinogen, interleukin (IL)-6, IL-10, IL-18, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1α were assessed in blood samples. Data were analyzed and stratified according to biological sex using multiple linear regression models. In older women, SMI was inversely associated with the pro-inflammatory markers CRP (<i>β</i> = −0.372; <i>p</i> < 0.05), fibrinogen (<i>β</i> = −0.376; <i>p</i> < 0.05), and IL-6 (<i>β</i> = −0.369; <i>p</i> < 0.05). Importantly, these associations were independent of abdominal adiposity (waist circumference), protein intake, physical activity level, as well as any adherence to muscle strengthening guidelines (≥2 sessions/week). In contrast, no corresponding associations were observed in men. In conclusion, our findings indicate the detrimental influence of a pro-inflammatory environment on muscle health regardless of important lifestyle-related factors in older women. However, the lack of such associations in older men highlights the importance of considering biological sex when examining the complex interaction between the systemic inflammatory environment and muscle health.Oscar BergensAndreas NilssonFawzi KadiMDPI AGarticlemuscle massmuscle strengthaginginflammatory biomarkersobesityprotein intakeMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5316, p 5316 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	muscle mass muscle strength aging inflammatory biomarkers obesity protein intake Medicine R
spellingShingle	muscle mass muscle strength aging inflammatory biomarkers obesity protein intake Medicine R Oscar Bergens Andreas Nilsson Fawzi Kadi Associations between Circulating Inflammatory Biomarkers and Indicators of Muscle Health in Older Men and Women
description	Systemic inflammation is believed to contribute to declining muscle health during aging. The present study aims to examine associations between indicators of muscle health and pro- and anti-inflammatory biomarkers in older men and women, while also considering the impacts of physical activity and protein intake. An assessment of skeletal muscle index (SMI) by bioelectrical impedance analysis, handgrip strength, and 5-sit-to-stand time, using standardized procedures, was conducted in a population of older men (<i>n</i> = 90) and women (<i>n</i> = 148) aged 65–70 years. The inflammatory biomarkers C-reactive protein (CRP), fibrinogen, interleukin (IL)-6, IL-10, IL-18, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1α were assessed in blood samples. Data were analyzed and stratified according to biological sex using multiple linear regression models. In older women, SMI was inversely associated with the pro-inflammatory markers CRP (<i>β</i> = −0.372; <i>p</i> < 0.05), fibrinogen (<i>β</i> = −0.376; <i>p</i> < 0.05), and IL-6 (<i>β</i> = −0.369; <i>p</i> < 0.05). Importantly, these associations were independent of abdominal adiposity (waist circumference), protein intake, physical activity level, as well as any adherence to muscle strengthening guidelines (≥2 sessions/week). In contrast, no corresponding associations were observed in men. In conclusion, our findings indicate the detrimental influence of a pro-inflammatory environment on muscle health regardless of important lifestyle-related factors in older women. However, the lack of such associations in older men highlights the importance of considering biological sex when examining the complex interaction between the systemic inflammatory environment and muscle health.
format	article
author	Oscar Bergens Andreas Nilsson Fawzi Kadi
author_facet	Oscar Bergens Andreas Nilsson Fawzi Kadi
author_sort	Oscar Bergens
title	Associations between Circulating Inflammatory Biomarkers and Indicators of Muscle Health in Older Men and Women
title_short	Associations between Circulating Inflammatory Biomarkers and Indicators of Muscle Health in Older Men and Women
title_full	Associations between Circulating Inflammatory Biomarkers and Indicators of Muscle Health in Older Men and Women
title_fullStr	Associations between Circulating Inflammatory Biomarkers and Indicators of Muscle Health in Older Men and Women
title_full_unstemmed	Associations between Circulating Inflammatory Biomarkers and Indicators of Muscle Health in Older Men and Women
title_sort	associations between circulating inflammatory biomarkers and indicators of muscle health in older men and women
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4b464062d47d4544b176728ad6f9162e
work_keys_str_mv	AT oscarbergens associationsbetweencirculatinginflammatorybiomarkersandindicatorsofmusclehealthinoldermenandwomen AT andreasnilsson associationsbetweencirculatinginflammatorybiomarkersandindicatorsofmusclehealthinoldermenandwomen AT fawzikadi associationsbetweencirculatinginflammatorybiomarkersandindicatorsofmusclehealthinoldermenandwomen
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Associations between Circulating Inflammatory Biomarkers and Indicators of Muscle Health in Older Men and Women

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