An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis

An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis

Polycomb Repressor Complex 2 (PRC2) is frequently up-regulated in cancers. Here, the authors show that the tyrosine kinase c-Src stimulates mitochondrial function to signal energy sufficiency to mTORC1, increasing translation of the PRC2 subunits EZH2 and SUZ12 to support ErbB2-dependent tumours.

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Autores principales: Harvey W. Smith, Alison Hirukawa, Virginie Sanguin-Gendreau, Ipshita Nandi, Catherine R. Dufour, Dongmei Zuo, Kristofferson Tandoc, Matthew Leibovitch, Salendra Singh, Jonathan P. Rennhack, Matthew Swiatnicki, Cynthia Lavoie, Vasilios Papavasiliou, Carolin Temps, Neil O. Carragher, Asier Unciti-Broceta, Paul Savage, Mark Basik, Vincent van Hoef, Ola Larsson, Caroline L. Cooper, Ana Cristina Vargas Calderon, Jane Beith, Ewan Millar, Christina Selinger, Vincent Giguère, Morag Park, Lyndsay N. Harris, Vinay Varadan, Eran R. Andrechek, Sandra A. O’Toole, Ivan Topisirovic, William J. Muller
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/4b4ac9959bb3404bb739e2634c53409f
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spelling oai:doaj.org-article:4b4ac9959bb3404bb739e2634c53409f2021-12-02T17:01:27ZAn ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis10.1038/s41467-019-10681-42041-1723https://doaj.org/article/4b4ac9959bb3404bb739e2634c53409f2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10681-4https://doaj.org/toc/2041-1723Polycomb Repressor Complex 2 (PRC2) is frequently up-regulated in cancers. Here, the authors show that the tyrosine kinase c-Src stimulates mitochondrial function to signal energy sufficiency to mTORC1, increasing translation of the PRC2 subunits EZH2 and SUZ12 to support ErbB2-dependent tumours.Harvey W. SmithAlison HirukawaVirginie Sanguin-GendreauIpshita NandiCatherine R. DufourDongmei ZuoKristofferson TandocMatthew LeibovitchSalendra SinghJonathan P. RennhackMatthew SwiatnickiCynthia LavoieVasilios PapavasiliouCarolin TempsNeil O. CarragherAsier Unciti-BrocetaPaul SavageMark BasikVincent van HoefOla LarssonCaroline L. CooperAna Cristina Vargas CalderonJane BeithEwan MillarChristina SelingerVincent GiguèreMorag ParkLyndsay N. HarrisVinay VaradanEran R. AndrechekSandra A. O’TooleIvan TopisirovicWilliam J. MullerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Harvey W. Smith
Alison Hirukawa
Virginie Sanguin-Gendreau
Ipshita Nandi
Catherine R. Dufour
Dongmei Zuo
Kristofferson Tandoc
Matthew Leibovitch
Salendra Singh
Jonathan P. Rennhack
Matthew Swiatnicki
Cynthia Lavoie
Vasilios Papavasiliou
Carolin Temps
Neil O. Carragher
Asier Unciti-Broceta
Paul Savage
Mark Basik
Vincent van Hoef
Ola Larsson
Caroline L. Cooper
Ana Cristina Vargas Calderon
Jane Beith
Ewan Millar
Christina Selinger
Vincent Giguère
Morag Park
Lyndsay N. Harris
Vinay Varadan
Eran R. Andrechek
Sandra A. O’Toole
Ivan Topisirovic
William J. Muller
An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis
description Polycomb Repressor Complex 2 (PRC2) is frequently up-regulated in cancers. Here, the authors show that the tyrosine kinase c-Src stimulates mitochondrial function to signal energy sufficiency to mTORC1, increasing translation of the PRC2 subunits EZH2 and SUZ12 to support ErbB2-dependent tumours.
format article
author Harvey W. Smith
Alison Hirukawa
Virginie Sanguin-Gendreau
Ipshita Nandi
Catherine R. Dufour
Dongmei Zuo
Kristofferson Tandoc
Matthew Leibovitch
Salendra Singh
Jonathan P. Rennhack
Matthew Swiatnicki
Cynthia Lavoie
Vasilios Papavasiliou
Carolin Temps
Neil O. Carragher
Asier Unciti-Broceta
Paul Savage
Mark Basik
Vincent van Hoef
Ola Larsson
Caroline L. Cooper
Ana Cristina Vargas Calderon
Jane Beith
Ewan Millar
Christina Selinger
Vincent Giguère
Morag Park
Lyndsay N. Harris
Vinay Varadan
Eran R. Andrechek
Sandra A. O’Toole
Ivan Topisirovic
William J. Muller
author_facet Harvey W. Smith
Alison Hirukawa
Virginie Sanguin-Gendreau
Ipshita Nandi
Catherine R. Dufour
Dongmei Zuo
Kristofferson Tandoc
Matthew Leibovitch
Salendra Singh
Jonathan P. Rennhack
Matthew Swiatnicki
Cynthia Lavoie
Vasilios Papavasiliou
Carolin Temps
Neil O. Carragher
Asier Unciti-Broceta
Paul Savage
Mark Basik
Vincent van Hoef
Ola Larsson
Caroline L. Cooper
Ana Cristina Vargas Calderon
Jane Beith
Ewan Millar
Christina Selinger
Vincent Giguère
Morag Park
Lyndsay N. Harris
Vinay Varadan
Eran R. Andrechek
Sandra A. O’Toole
Ivan Topisirovic
William J. Muller
author_sort Harvey W. Smith
title An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis
title_short An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis
title_full An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis
title_fullStr An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis
title_full_unstemmed An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis
title_sort erbb2/c-src axis links bioenergetics with prc2 translation to drive epigenetic reprogramming and mammary tumorigenesis
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/4b4ac9959bb3404bb739e2634c53409f
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