Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner

ATP-dependent chromatin remodelers are often found mutated in human cancers. Here, the authors characterize the nucleosome remodelling properties of cancer-associated mutants of the Drosophila Chd4 homolog dMi-2.

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Autores principales:	Kristina Kovač, Anja Sauer, Igor Mačinković, Stephan Awe, Florian Finkernagel, Helen Hoffmeister, Andreas Fuchs, Rolf Müller, Christina Rathke, Gernot Längst, Alexander Brehm
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b4ca0b894bf4df581150e361275c81e
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spelling	oai:doaj.org-article:4b4ca0b894bf4df581150e361275c81e2021-12-02T14:39:22ZTumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner10.1038/s41467-018-04503-22041-1723https://doaj.org/article/4b4ca0b894bf4df581150e361275c81e2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04503-2https://doaj.org/toc/2041-1723ATP-dependent chromatin remodelers are often found mutated in human cancers. Here, the authors characterize the nucleosome remodelling properties of cancer-associated mutants of the Drosophila Chd4 homolog dMi-2.Kristina KovačAnja SauerIgor MačinkovićStephan AweFlorian FinkernagelHelen HoffmeisterAndreas FuchsRolf MüllerChristina RathkeGernot LängstAlexander BrehmNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kristina Kovač Anja Sauer Igor Mačinković Stephan Awe Florian Finkernagel Helen Hoffmeister Andreas Fuchs Rolf Müller Christina Rathke Gernot Längst Alexander Brehm Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner
description	ATP-dependent chromatin remodelers are often found mutated in human cancers. Here, the authors characterize the nucleosome remodelling properties of cancer-associated mutants of the Drosophila Chd4 homolog dMi-2.
format	article
author	Kristina Kovač Anja Sauer Igor Mačinković Stephan Awe Florian Finkernagel Helen Hoffmeister Andreas Fuchs Rolf Müller Christina Rathke Gernot Längst Alexander Brehm
author_facet	Kristina Kovač Anja Sauer Igor Mačinković Stephan Awe Florian Finkernagel Helen Hoffmeister Andreas Fuchs Rolf Müller Christina Rathke Gernot Längst Alexander Brehm
author_sort	Kristina Kovač
title	Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner
title_short	Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner
title_full	Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner
title_fullStr	Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner
title_full_unstemmed	Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner
title_sort	tumour-associated missense mutations in the dmi-2 atpase alters nucleosome remodelling properties in a mutation-specific manner
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4b4ca0b894bf4df581150e361275c81e
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Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner

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