Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis

It is unclear whether cancer-related hypercoagulation and neutrophilia contribute to tumorigenesis. In this study, the authors find that activation of the complement cascade causes hypercoagulation that leads to polarization of neutrophils in a mouse model of intestinal cancer, and show that blockin...

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Autores principales:	Silvia Guglietta, Andrea Chiavelli, Elena Zagato, Carsten Krieg, Sara Gandini, Paola Simona Ravenda, Barbara Bazolli, Bao Lu, Giuseppe Penna, Maria Rescigno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b4db557b4774e8281aaa7e5d8cfe5dc
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spelling	oai:doaj.org-article:4b4db557b4774e8281aaa7e5d8cfe5dc2021-12-02T16:49:57ZCoagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis10.1038/ncomms110372041-1723https://doaj.org/article/4b4db557b4774e8281aaa7e5d8cfe5dc2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11037https://doaj.org/toc/2041-1723It is unclear whether cancer-related hypercoagulation and neutrophilia contribute to tumorigenesis. In this study, the authors find that activation of the complement cascade causes hypercoagulation that leads to polarization of neutrophils in a mouse model of intestinal cancer, and show that blocking complement activation can reduce tumour formation.Silvia GugliettaAndrea ChiavelliElena ZagatoCarsten KriegSara GandiniPaola Simona RavendaBarbara BazolliBao LuGiuseppe PennaMaria RescignoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Silvia Guglietta Andrea Chiavelli Elena Zagato Carsten Krieg Sara Gandini Paola Simona Ravenda Barbara Bazolli Bao Lu Giuseppe Penna Maria Rescigno Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis
description	It is unclear whether cancer-related hypercoagulation and neutrophilia contribute to tumorigenesis. In this study, the authors find that activation of the complement cascade causes hypercoagulation that leads to polarization of neutrophils in a mouse model of intestinal cancer, and show that blocking complement activation can reduce tumour formation.
format	article
author	Silvia Guglietta Andrea Chiavelli Elena Zagato Carsten Krieg Sara Gandini Paola Simona Ravenda Barbara Bazolli Bao Lu Giuseppe Penna Maria Rescigno
author_facet	Silvia Guglietta Andrea Chiavelli Elena Zagato Carsten Krieg Sara Gandini Paola Simona Ravenda Barbara Bazolli Bao Lu Giuseppe Penna Maria Rescigno
author_sort	Silvia Guglietta
title	Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis
title_short	Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis
title_full	Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis
title_fullStr	Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis
title_full_unstemmed	Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis
title_sort	coagulation induced by c3ar-dependent netosis drives protumorigenic neutrophils during small intestinal tumorigenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4b4db557b4774e8281aaa7e5d8cfe5dc
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Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis

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