The membrane attack complex as an indicator of complement hyperactivation in type 2 diabetes mellitus

Aim. Comparative analysis of the levels of the membrane attack complex (MAC) - an end product of complement activation, and of hemolytic activitiesof C1 and C3 complement components in sera of patients with diabetes mellitus 2 (DM2) and healthy subjects. Materials and methods. 37 DM2 patients (7 m...

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Autores principales:	Elina Alexandrovna Arakelova, Meri Robertovna Ovsepyan, Anna Surenovna Boyadzhyan, Arsen Artashesovich Arakelyan, Astkhik Artavazdovna Gevorkyan, Ashot Andreevich Mamikonyan
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2011
Materias:	type 2 diabetes mellitus membrane attack complex complement system Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/4b50599f7a7948a4a79ea67d23c66339
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spelling	oai:doaj.org-article:4b50599f7a7948a4a79ea67d23c663392021-11-14T09:00:16ZThe membrane attack complex as an indicator of complement hyperactivation in type 2 diabetes mellitus2072-03512072-037810.14341/2072-0351-6218https://doaj.org/article/4b50599f7a7948a4a79ea67d23c663392011-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6218https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. Comparative analysis of the levels of the membrane attack complex (MAC) - an end product of complement activation, and of hemolytic activitiesof C1 and C3 complement components in sera of patients with diabetes mellitus 2 (DM2) and healthy subjects. Materials and methods. 37 DM2 patients (7 men, 26 women, mean age 58?9 years (M?б) and 37 healthy subjects without a family history of hereditarydiabetes (17 men, 20 women, mean age 52?12 years). Serum MAC levels were measured by ELISA, C1 and C3 hemolytic activities by usingrabbit antibody-sensitized ram erythrocytes and C1, C3-deficient sera. Results. Mean values of all measured parameters in DM2 patients were significantly higher than in controls. Conclusion. Pathogenesis of DM2 is characterized by hyperactivation of the complement system including both the classical and terminal cascadesand by hyperproduction of its cytotoxic products.Elina Alexandrovna ArakelovaMeri Robertovna OvsepyanAnna Surenovna BoyadzhyanArsen Artashesovich ArakelyanAstkhik Artavazdovna GevorkyanAshot Andreevich MamikonyanEndocrinology Research Centrearticletype 2 diabetes mellitusmembrane attack complexcomplement systemNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 14, Iss 3, Pp 17-20 (2011)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus membrane attack complex complement system Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus membrane attack complex complement system Nutritional diseases. Deficiency diseases RC620-627 Elina Alexandrovna Arakelova Meri Robertovna Ovsepyan Anna Surenovna Boyadzhyan Arsen Artashesovich Arakelyan Astkhik Artavazdovna Gevorkyan Ashot Andreevich Mamikonyan The membrane attack complex as an indicator of complement hyperactivation in type 2 diabetes mellitus
description	Aim. Comparative analysis of the levels of the membrane attack complex (MAC) - an end product of complement activation, and of hemolytic activitiesof C1 and C3 complement components in sera of patients with diabetes mellitus 2 (DM2) and healthy subjects. Materials and methods. 37 DM2 patients (7 men, 26 women, mean age 58?9 years (M?б) and 37 healthy subjects without a family history of hereditarydiabetes (17 men, 20 women, mean age 52?12 years). Serum MAC levels were measured by ELISA, C1 and C3 hemolytic activities by usingrabbit antibody-sensitized ram erythrocytes and C1, C3-deficient sera. Results. Mean values of all measured parameters in DM2 patients were significantly higher than in controls. Conclusion. Pathogenesis of DM2 is characterized by hyperactivation of the complement system including both the classical and terminal cascadesand by hyperproduction of its cytotoxic products.
format	article
author	Elina Alexandrovna Arakelova Meri Robertovna Ovsepyan Anna Surenovna Boyadzhyan Arsen Artashesovich Arakelyan Astkhik Artavazdovna Gevorkyan Ashot Andreevich Mamikonyan
author_facet	Elina Alexandrovna Arakelova Meri Robertovna Ovsepyan Anna Surenovna Boyadzhyan Arsen Artashesovich Arakelyan Astkhik Artavazdovna Gevorkyan Ashot Andreevich Mamikonyan
author_sort	Elina Alexandrovna Arakelova
title	The membrane attack complex as an indicator of complement hyperactivation in type 2 diabetes mellitus
title_short	The membrane attack complex as an indicator of complement hyperactivation in type 2 diabetes mellitus
title_full	The membrane attack complex as an indicator of complement hyperactivation in type 2 diabetes mellitus
title_fullStr	The membrane attack complex as an indicator of complement hyperactivation in type 2 diabetes mellitus
title_full_unstemmed	The membrane attack complex as an indicator of complement hyperactivation in type 2 diabetes mellitus
title_sort	membrane attack complex as an indicator of complement hyperactivation in type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2011
url	https://doaj.org/article/4b50599f7a7948a4a79ea67d23c66339
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The membrane attack complex as an indicator of complement hyperactivation in type 2 diabetes mellitus

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