The impact of infection complications after trauma differs according to trauma severity

Abstract The impact of infection on the prognosis of trauma patients according to severity remains unclear. We assessed the impact of infection complications on in-hospital mortality among patients with trauma according to severity. This retrospective cohort study used a nationwide registry of traum...

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Autores principales:	Akira Komori, Hiroki Iriyama, Takako Kainoh, Makoto Aoki, Toshio Naito, Toshikazu Abe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b548aee926a4653a67e8f8b555e2b6e
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spelling	oai:doaj.org-article:4b548aee926a4653a67e8f8b555e2b6e2021-12-02T18:34:20ZThe impact of infection complications after trauma differs according to trauma severity10.1038/s41598-021-93314-52045-2322https://doaj.org/article/4b548aee926a4653a67e8f8b555e2b6e2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93314-5https://doaj.org/toc/2045-2322Abstract The impact of infection on the prognosis of trauma patients according to severity remains unclear. We assessed the impact of infection complications on in-hospital mortality among patients with trauma according to severity. This retrospective cohort study used a nationwide registry of trauma patients. Patients aged ≥ 18 years with blunt or penetrating trauma who were admitted to intensive care units or general wards between 2004 and 2017 were included. We compared the baseline characteristics and outcomes between patients with and without infection and conducted a multivariable logistic regression analysis to investigate the impact of infection on in-hospital mortality according to trauma severity, which was classified as mild [Injury Severity Score (ISS) < 15], moderate (ISS 15–29), or severe (ISS ≥ 30). Among the 150,948 patients in this study, 10,338 (6.8%) developed infections. Patients with infection had greater in-hospital mortality than patients without infection [1085 (10.5%) vs. 2898 (2.1%), p < 0.01]. After adjusting for clinical characteristics, in-hospital mortality differed between trauma patients with and without infection according to trauma severity [17.1% (95% CI 15.2–18.9%) vs. 2.9% (95% CI 2.7–3.1%), p < 0.01, in patients with mild trauma; 14.8% (95% CI 13.3–16.3%) vs. 8.4% (95% CI 7.9–8.8%), p < 0.01, in patients with moderate trauma; and 13.5% (95% CI 11.2–15.7%) vs. 13.7% (95% CI 12.4–14.9%), p = 0.86, in patients with severe trauma]. In conclusion, the effect of infection complications in patients with trauma on in-hospital mortality differs by trauma severity.Akira KomoriHiroki IriyamaTakako KainohMakoto AokiToshio NaitoToshikazu AbeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Akira Komori Hiroki Iriyama Takako Kainoh Makoto Aoki Toshio Naito Toshikazu Abe The impact of infection complications after trauma differs according to trauma severity
description	Abstract The impact of infection on the prognosis of trauma patients according to severity remains unclear. We assessed the impact of infection complications on in-hospital mortality among patients with trauma according to severity. This retrospective cohort study used a nationwide registry of trauma patients. Patients aged ≥ 18 years with blunt or penetrating trauma who were admitted to intensive care units or general wards between 2004 and 2017 were included. We compared the baseline characteristics and outcomes between patients with and without infection and conducted a multivariable logistic regression analysis to investigate the impact of infection on in-hospital mortality according to trauma severity, which was classified as mild [Injury Severity Score (ISS) < 15], moderate (ISS 15–29), or severe (ISS ≥ 30). Among the 150,948 patients in this study, 10,338 (6.8%) developed infections. Patients with infection had greater in-hospital mortality than patients without infection [1085 (10.5%) vs. 2898 (2.1%), p < 0.01]. After adjusting for clinical characteristics, in-hospital mortality differed between trauma patients with and without infection according to trauma severity [17.1% (95% CI 15.2–18.9%) vs. 2.9% (95% CI 2.7–3.1%), p < 0.01, in patients with mild trauma; 14.8% (95% CI 13.3–16.3%) vs. 8.4% (95% CI 7.9–8.8%), p < 0.01, in patients with moderate trauma; and 13.5% (95% CI 11.2–15.7%) vs. 13.7% (95% CI 12.4–14.9%), p = 0.86, in patients with severe trauma]. In conclusion, the effect of infection complications in patients with trauma on in-hospital mortality differs by trauma severity.
format	article
author	Akira Komori Hiroki Iriyama Takako Kainoh Makoto Aoki Toshio Naito Toshikazu Abe
author_facet	Akira Komori Hiroki Iriyama Takako Kainoh Makoto Aoki Toshio Naito Toshikazu Abe
author_sort	Akira Komori
title	The impact of infection complications after trauma differs according to trauma severity
title_short	The impact of infection complications after trauma differs according to trauma severity
title_full	The impact of infection complications after trauma differs according to trauma severity
title_fullStr	The impact of infection complications after trauma differs according to trauma severity
title_full_unstemmed	The impact of infection complications after trauma differs according to trauma severity
title_sort	impact of infection complications after trauma differs according to trauma severity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4b548aee926a4653a67e8f8b555e2b6e
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The impact of infection complications after trauma differs according to trauma severity

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