Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection

Abstract Throughout the lifespan of an individual, the immune system undergoes complex changes while facing novel and chronic infections. Helminths, which infect over one billion people and impose heavy livestock productivity losses, typically cause chronic infections by avoiding and suppressing hos...

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Autores principales:	Simon A. Babayan, Amy Sinclair, Jessica S. Duprez, Colin Selman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b561716ad834b1eb109ddfda599fb23
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spelling	oai:doaj.org-article:4b561716ad834b1eb109ddfda599fb232021-12-02T15:08:42ZChronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection10.1038/s41598-018-22083-52045-2322https://doaj.org/article/4b561716ad834b1eb109ddfda599fb232018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-22083-5https://doaj.org/toc/2045-2322Abstract Throughout the lifespan of an individual, the immune system undergoes complex changes while facing novel and chronic infections. Helminths, which infect over one billion people and impose heavy livestock productivity losses, typically cause chronic infections by avoiding and suppressing host immunity. Yet, how age affects immune responses to lifelong parasitic infection is poorly understood. To disentangle the processes involved, we employed supervised statistical learning techniques to identify which factors among haematopoietic stem and progenitor cells (HSPC), and both innate and adaptive responses regulate parasite burdens and how they are affected by host age. Older mice harboured greater numbers of the parasites’ offspring than younger mice. Protective immune responses that did not vary with age were dominated by HSPC, while ageing specifically eroded adaptive immunity, with reduced numbers of naïve T cells, poor T cell responsiveness to parasites, and impaired antibody production. We identified immune factors consistent with previously-reported immune responses to helminths, and also revealed novel interactions between helminths and HSPC maturation. Our approach thus allowed disentangling the concurrent effects of ageing and infection across the full maturation cycle of the immune response and highlights the potential of such approaches to improve understanding of the immune system within the whole organism.Simon A. BabayanAmy SinclairJessica S. DuprezColin SelmanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Simon A. Babayan Amy Sinclair Jessica S. Duprez Colin Selman Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection
description	Abstract Throughout the lifespan of an individual, the immune system undergoes complex changes while facing novel and chronic infections. Helminths, which infect over one billion people and impose heavy livestock productivity losses, typically cause chronic infections by avoiding and suppressing host immunity. Yet, how age affects immune responses to lifelong parasitic infection is poorly understood. To disentangle the processes involved, we employed supervised statistical learning techniques to identify which factors among haematopoietic stem and progenitor cells (HSPC), and both innate and adaptive responses regulate parasite burdens and how they are affected by host age. Older mice harboured greater numbers of the parasites’ offspring than younger mice. Protective immune responses that did not vary with age were dominated by HSPC, while ageing specifically eroded adaptive immunity, with reduced numbers of naïve T cells, poor T cell responsiveness to parasites, and impaired antibody production. We identified immune factors consistent with previously-reported immune responses to helminths, and also revealed novel interactions between helminths and HSPC maturation. Our approach thus allowed disentangling the concurrent effects of ageing and infection across the full maturation cycle of the immune response and highlights the potential of such approaches to improve understanding of the immune system within the whole organism.
format	article
author	Simon A. Babayan Amy Sinclair Jessica S. Duprez Colin Selman
author_facet	Simon A. Babayan Amy Sinclair Jessica S. Duprez Colin Selman
author_sort	Simon A. Babayan
title	Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection
title_short	Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection
title_full	Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection
title_fullStr	Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection
title_full_unstemmed	Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection
title_sort	chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4b561716ad834b1eb109ddfda599fb23
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Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection

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