Cyclic stretch induces cell reorientation on substrates by destabilizing catch bonds in focal adhesions.

A minimal model of cellular mechanosensing system that consists of a single stress fiber adhering on a substrate via two focal adhesions made of catch bonds is adopted to investigate the phenomena of cell reorientation on substrates induced by an applied uniaxial cyclic stretch. The model indicates...

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Autores principales:	Bin Chen, Ralf Kemkemer, Martin Deibler, Joachim Spatz, Huajian Gao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b568d8ff73a42fba2274abbfc3e31a2
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spelling	oai:doaj.org-article:4b568d8ff73a42fba2274abbfc3e31a22021-11-18T08:09:11ZCyclic stretch induces cell reorientation on substrates by destabilizing catch bonds in focal adhesions.1932-620310.1371/journal.pone.0048346https://doaj.org/article/4b568d8ff73a42fba2274abbfc3e31a22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23152769/?tool=EBIhttps://doaj.org/toc/1932-6203A minimal model of cellular mechanosensing system that consists of a single stress fiber adhering on a substrate via two focal adhesions made of catch bonds is adopted to investigate the phenomena of cell reorientation on substrates induced by an applied uniaxial cyclic stretch. The model indicates that the catch bonds in the focal adhesions experience a periodically oscillating internal force with amplitude and frequency controlled by two intrinsic clocks of the stress fiber, one associated with localized activation and the other with homogeneous activation of sarcomere units along the stress fiber. It is shown that this oscillating force due to cyclic stretch tends to destabilize focal adhesions by reducing the lifetime of catch bonds. The resulting slide or relocation of focal adhesions then causes the associated stress fiber to shorten and rotate to configurations nearly perpendicular to the stretching direction. These predicted behaviors from our model are consistent with a wide range of experimental observations.Bin ChenRalf KemkemerMartin DeiblerJoachim SpatzHuajian GaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48346 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bin Chen Ralf Kemkemer Martin Deibler Joachim Spatz Huajian Gao Cyclic stretch induces cell reorientation on substrates by destabilizing catch bonds in focal adhesions.
description	A minimal model of cellular mechanosensing system that consists of a single stress fiber adhering on a substrate via two focal adhesions made of catch bonds is adopted to investigate the phenomena of cell reorientation on substrates induced by an applied uniaxial cyclic stretch. The model indicates that the catch bonds in the focal adhesions experience a periodically oscillating internal force with amplitude and frequency controlled by two intrinsic clocks of the stress fiber, one associated with localized activation and the other with homogeneous activation of sarcomere units along the stress fiber. It is shown that this oscillating force due to cyclic stretch tends to destabilize focal adhesions by reducing the lifetime of catch bonds. The resulting slide or relocation of focal adhesions then causes the associated stress fiber to shorten and rotate to configurations nearly perpendicular to the stretching direction. These predicted behaviors from our model are consistent with a wide range of experimental observations.
format	article
author	Bin Chen Ralf Kemkemer Martin Deibler Joachim Spatz Huajian Gao
author_facet	Bin Chen Ralf Kemkemer Martin Deibler Joachim Spatz Huajian Gao
author_sort	Bin Chen
title	Cyclic stretch induces cell reorientation on substrates by destabilizing catch bonds in focal adhesions.
title_short	Cyclic stretch induces cell reorientation on substrates by destabilizing catch bonds in focal adhesions.
title_full	Cyclic stretch induces cell reorientation on substrates by destabilizing catch bonds in focal adhesions.
title_fullStr	Cyclic stretch induces cell reorientation on substrates by destabilizing catch bonds in focal adhesions.
title_full_unstemmed	Cyclic stretch induces cell reorientation on substrates by destabilizing catch bonds in focal adhesions.
title_sort	cyclic stretch induces cell reorientation on substrates by destabilizing catch bonds in focal adhesions.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/4b568d8ff73a42fba2274abbfc3e31a2
work_keys_str_mv	AT binchen cyclicstretchinducescellreorientationonsubstratesbydestabilizingcatchbondsinfocaladhesions AT ralfkemkemer cyclicstretchinducescellreorientationonsubstratesbydestabilizingcatchbondsinfocaladhesions AT martindeibler cyclicstretchinducescellreorientationonsubstratesbydestabilizingcatchbondsinfocaladhesions AT joachimspatz cyclicstretchinducescellreorientationonsubstratesbydestabilizingcatchbondsinfocaladhesions AT huajiangao cyclicstretchinducescellreorientationonsubstratesbydestabilizingcatchbondsinfocaladhesions
_version_	1718422165924085760

Cyclic stretch induces cell reorientation on substrates by destabilizing catch bonds in focal adhesions.

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