Cyclic stretch induces cell reorientation on substrates by destabilizing catch bonds in focal adhesions.

A minimal model of cellular mechanosensing system that consists of a single stress fiber adhering on a substrate via two focal adhesions made of catch bonds is adopted to investigate the phenomena of cell reorientation on substrates induced by an applied uniaxial cyclic stretch. The model indicates...

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Autores principales: Bin Chen, Ralf Kemkemer, Martin Deibler, Joachim Spatz, Huajian Gao
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/4b568d8ff73a42fba2274abbfc3e31a2
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