Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance

Abstract T2-weighted cardiovascular magnetic resonance (T2-CMR) of myocardial edema can quantify the area-at-risk (AAR) following acute myocardial infarction (AMI), and has been used to assess myocardial salvage by new cardioprotective therapies. However, some of these therapies may reduce edema, le...

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Autores principales:	Rachel K. Dongworth, Adrienne E. Campbell-Washburn, Hector A. Cabrera-Fuentes, Heerajnarain Bulluck, Thomas Roberts, Anthony N. Price, Sauri Hernández-Reséndiz, Roger J. Ordidge, David L. Thomas, Derek M. Yellon, Mark F. Lythgoe, Derek J. Hausenloy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b5a825347db4811b2bd0474faeac514
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spelling	oai:doaj.org-article:4b5a825347db4811b2bd0474faeac5142021-12-02T12:30:11ZQuantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance10.1038/s41598-017-02544-z2045-2322https://doaj.org/article/4b5a825347db4811b2bd0474faeac5142017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02544-zhttps://doaj.org/toc/2045-2322Abstract T2-weighted cardiovascular magnetic resonance (T2-CMR) of myocardial edema can quantify the area-at-risk (AAR) following acute myocardial infarction (AMI), and has been used to assess myocardial salvage by new cardioprotective therapies. However, some of these therapies may reduce edema, leading to an underestimation of the AAR by T2-CMR. Here, we investigated arterial spin labeling (ASL) perfusion CMR as a novel approach to quantify the AAR following AMI. Adult B6sv129-mice were subjected to in vivo left coronary artery ligation for 30 minutes followed by 72 hours reperfusion. T2-mapping was used to quantify the edema-based AAR (% of left ventricle) following ischemic preconditioning (IPC) or cyclosporin-A (CsA) treatment. In control animals, the AAR by T2-mapping corresponded to that delineated by histology. As expected, both IPC and CsA reduced MI size. However, IPC, but not CsA, also reduced myocardial edema leading to an underestimation of the AAR by T2-mapping. In contrast, regions of reduced myocardial perfusion delineated by cardiac ASL were able to delineate the AAR when compared to both T2-mapping and histology in control animals, and were not affected by either IPC or CsA. Therefore, ASL perfusion CMR may be an alternative method for quantifying the AAR following AMI, which unlike T2-mapping, is not affected by IPC.Rachel K. DongworthAdrienne E. Campbell-WashburnHector A. Cabrera-FuentesHeerajnarain BulluckThomas RobertsAnthony N. PriceSauri Hernández-ReséndizRoger J. OrdidgeDavid L. ThomasDerek M. YellonMark F. LythgoeDerek J. HausenloyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rachel K. Dongworth Adrienne E. Campbell-Washburn Hector A. Cabrera-Fuentes Heerajnarain Bulluck Thomas Roberts Anthony N. Price Sauri Hernández-Reséndiz Roger J. Ordidge David L. Thomas Derek M. Yellon Mark F. Lythgoe Derek J. Hausenloy Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance
description	Abstract T2-weighted cardiovascular magnetic resonance (T2-CMR) of myocardial edema can quantify the area-at-risk (AAR) following acute myocardial infarction (AMI), and has been used to assess myocardial salvage by new cardioprotective therapies. However, some of these therapies may reduce edema, leading to an underestimation of the AAR by T2-CMR. Here, we investigated arterial spin labeling (ASL) perfusion CMR as a novel approach to quantify the AAR following AMI. Adult B6sv129-mice were subjected to in vivo left coronary artery ligation for 30 minutes followed by 72 hours reperfusion. T2-mapping was used to quantify the edema-based AAR (% of left ventricle) following ischemic preconditioning (IPC) or cyclosporin-A (CsA) treatment. In control animals, the AAR by T2-mapping corresponded to that delineated by histology. As expected, both IPC and CsA reduced MI size. However, IPC, but not CsA, also reduced myocardial edema leading to an underestimation of the AAR by T2-mapping. In contrast, regions of reduced myocardial perfusion delineated by cardiac ASL were able to delineate the AAR when compared to both T2-mapping and histology in control animals, and were not affected by either IPC or CsA. Therefore, ASL perfusion CMR may be an alternative method for quantifying the AAR following AMI, which unlike T2-mapping, is not affected by IPC.
format	article
author	Rachel K. Dongworth Adrienne E. Campbell-Washburn Hector A. Cabrera-Fuentes Heerajnarain Bulluck Thomas Roberts Anthony N. Price Sauri Hernández-Reséndiz Roger J. Ordidge David L. Thomas Derek M. Yellon Mark F. Lythgoe Derek J. Hausenloy
author_facet	Rachel K. Dongworth Adrienne E. Campbell-Washburn Hector A. Cabrera-Fuentes Heerajnarain Bulluck Thomas Roberts Anthony N. Price Sauri Hernández-Reséndiz Roger J. Ordidge David L. Thomas Derek M. Yellon Mark F. Lythgoe Derek J. Hausenloy
author_sort	Rachel K. Dongworth
title	Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance
title_short	Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance
title_full	Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance
title_fullStr	Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance
title_full_unstemmed	Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance
title_sort	quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4b5a825347db4811b2bd0474faeac514
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Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance

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