Horizontal gene transfer of a ColV plasmid has resulted in a dominant avian clonal type of Salmonella enterica serovar Kentucky.

Salmonella enterica continues to be a significant cause of foodborne gastrointestinal illness in humans. A wide variety of Salmonella serovars have been isolated from production birds and from retail poultry meat. Recently, though, S. enterica subsp. enterica serovar Kentucky has emerged as one of t...

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Autores principales:	Timothy J Johnson, Jessica L Thorsness, Cole P Anderson, Aaron M Lynne, Steven L Foley, Jing Han, W Florian Fricke, Patrick F McDermott, David G White, Mahesh Khatri, Adam L Stell, Cristian Flores, Randall S Singer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b5a8e2d709b4596b1ae96b0f6dee2b0
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spelling	oai:doaj.org-article:4b5a8e2d709b4596b1ae96b0f6dee2b02021-11-18T07:01:20ZHorizontal gene transfer of a ColV plasmid has resulted in a dominant avian clonal type of Salmonella enterica serovar Kentucky.1932-620310.1371/journal.pone.0015524https://doaj.org/article/4b5a8e2d709b4596b1ae96b0f6dee2b02010-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21203520/?tool=EBIhttps://doaj.org/toc/1932-6203Salmonella enterica continues to be a significant cause of foodborne gastrointestinal illness in humans. A wide variety of Salmonella serovars have been isolated from production birds and from retail poultry meat. Recently, though, S. enterica subsp. enterica serovar Kentucky has emerged as one of the prominent Salmonella serovars isolated from broiler chickens. Recent work suggests that its emergence apparently coincides with its acquisition of a ColV virulence plasmid. In the present study, we examined 902 Salmonella isolates belonging to 59 different serovars for the presence of this plasmid. Of the serovars examined, the ColV plasmid was found only among isolates belonging to the serovars Kentucky (72.9%), Typhimurium (15.0%) and Heidelberg (1.7%). We demonstrated that a single PFGE clonal type of S. Kentucky harbors this plasmid, and acquisition of this plasmid by S. Kentucky significantly increased its ability to colonize the chicken cecum and cause extraintestinal disease. Comparison of the completed sequences of three ColV plasmids from S. Kentucky isolated from different geographical locales, timepoints and sources revealed a nearly identical genetic structure with few single nucleotide changes or insertions/deletions. Overall, it appears that the ColV plasmid was recently acquired by a single clonal type S. Kentucky and confers to its host enhanced colonization and fitness capabilities. Thus, the potential for horizontal gene transfer of virulence and fitness factors to Salmonella from other enteric bacteria exists in poultry, representing a potential human health hazard.Timothy J JohnsonJessica L ThorsnessCole P AndersonAaron M LynneSteven L FoleyJing HanW Florian FrickePatrick F McDermottDavid G WhiteMahesh KhatriAdam L StellCristian FloresRandall S SingerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 12, p e15524 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Timothy J Johnson Jessica L Thorsness Cole P Anderson Aaron M Lynne Steven L Foley Jing Han W Florian Fricke Patrick F McDermott David G White Mahesh Khatri Adam L Stell Cristian Flores Randall S Singer Horizontal gene transfer of a ColV plasmid has resulted in a dominant avian clonal type of Salmonella enterica serovar Kentucky.
description	Salmonella enterica continues to be a significant cause of foodborne gastrointestinal illness in humans. A wide variety of Salmonella serovars have been isolated from production birds and from retail poultry meat. Recently, though, S. enterica subsp. enterica serovar Kentucky has emerged as one of the prominent Salmonella serovars isolated from broiler chickens. Recent work suggests that its emergence apparently coincides with its acquisition of a ColV virulence plasmid. In the present study, we examined 902 Salmonella isolates belonging to 59 different serovars for the presence of this plasmid. Of the serovars examined, the ColV plasmid was found only among isolates belonging to the serovars Kentucky (72.9%), Typhimurium (15.0%) and Heidelberg (1.7%). We demonstrated that a single PFGE clonal type of S. Kentucky harbors this plasmid, and acquisition of this plasmid by S. Kentucky significantly increased its ability to colonize the chicken cecum and cause extraintestinal disease. Comparison of the completed sequences of three ColV plasmids from S. Kentucky isolated from different geographical locales, timepoints and sources revealed a nearly identical genetic structure with few single nucleotide changes or insertions/deletions. Overall, it appears that the ColV plasmid was recently acquired by a single clonal type S. Kentucky and confers to its host enhanced colonization and fitness capabilities. Thus, the potential for horizontal gene transfer of virulence and fitness factors to Salmonella from other enteric bacteria exists in poultry, representing a potential human health hazard.
format	article
author	Timothy J Johnson Jessica L Thorsness Cole P Anderson Aaron M Lynne Steven L Foley Jing Han W Florian Fricke Patrick F McDermott David G White Mahesh Khatri Adam L Stell Cristian Flores Randall S Singer
author_facet	Timothy J Johnson Jessica L Thorsness Cole P Anderson Aaron M Lynne Steven L Foley Jing Han W Florian Fricke Patrick F McDermott David G White Mahesh Khatri Adam L Stell Cristian Flores Randall S Singer
author_sort	Timothy J Johnson
title	Horizontal gene transfer of a ColV plasmid has resulted in a dominant avian clonal type of Salmonella enterica serovar Kentucky.
title_short	Horizontal gene transfer of a ColV plasmid has resulted in a dominant avian clonal type of Salmonella enterica serovar Kentucky.
title_full	Horizontal gene transfer of a ColV plasmid has resulted in a dominant avian clonal type of Salmonella enterica serovar Kentucky.
title_fullStr	Horizontal gene transfer of a ColV plasmid has resulted in a dominant avian clonal type of Salmonella enterica serovar Kentucky.
title_full_unstemmed	Horizontal gene transfer of a ColV plasmid has resulted in a dominant avian clonal type of Salmonella enterica serovar Kentucky.
title_sort	horizontal gene transfer of a colv plasmid has resulted in a dominant avian clonal type of salmonella enterica serovar kentucky.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/4b5a8e2d709b4596b1ae96b0f6dee2b0
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Horizontal gene transfer of a ColV plasmid has resulted in a dominant avian clonal type of Salmonella enterica serovar Kentucky.

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