Geographic variation in Alzheimer's disease mortality.

<h4>Objective</h4>Accumulating evidence suggests the possibility that early life exposures may contribute to risk of Alzheimer's Disease (AD). This paper explores geographic disparities in AD mortality based on both state of residence in older age as well as state of birth measures...

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Autores principales:	Michael Topping, Jinho Kim, Jason Fletcher
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b5d805848e14d9f87a43cf34f798ac5
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spelling	oai:doaj.org-article:4b5d805848e14d9f87a43cf34f798ac52021-12-02T20:09:42ZGeographic variation in Alzheimer's disease mortality.1932-620310.1371/journal.pone.0254174https://doaj.org/article/4b5d805848e14d9f87a43cf34f798ac52021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254174https://doaj.org/toc/1932-6203<h4>Objective</h4>Accumulating evidence suggests the possibility that early life exposures may contribute to risk of Alzheimer's Disease (AD). This paper explores geographic disparities in AD mortality based on both state of residence in older age as well as state of birth measures in order to assess the relative importance of these factors.<h4>Methods</h4>We use a subset of a large survey, the NIH-AARP Diet and Health Study, of over 150,000 individuals aged 65-70 with 15 years of mortality follow-up, allowing us to study over 1050 cases of AD mortality. We use multi-level logistic regression, where individuals are nested within states of residence and/or states of birth, to assess the contributions of place to AD mortality variation.<h4>Results</h4>We show that state of birth explains a modest amount of variation in AD mortality, approximately 4%, which is consistent with life course theories that suggest that early life conditions can produce old age health disparities. However, we also show that nearly all of the variation from state of birth is explained by state of residence in old age.<h4>Conclusions</h4>These results suggest that later life factors are potentially more consequential targets for intervention in reducing AD mortality and provide some evidence against the importance of macro-level environmental exposures at birth as a core determinant of later AD.Michael ToppingJinho KimJason FletcherPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254174 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael Topping Jinho Kim Jason Fletcher Geographic variation in Alzheimer's disease mortality.
description	<h4>Objective</h4>Accumulating evidence suggests the possibility that early life exposures may contribute to risk of Alzheimer's Disease (AD). This paper explores geographic disparities in AD mortality based on both state of residence in older age as well as state of birth measures in order to assess the relative importance of these factors.<h4>Methods</h4>We use a subset of a large survey, the NIH-AARP Diet and Health Study, of over 150,000 individuals aged 65-70 with 15 years of mortality follow-up, allowing us to study over 1050 cases of AD mortality. We use multi-level logistic regression, where individuals are nested within states of residence and/or states of birth, to assess the contributions of place to AD mortality variation.<h4>Results</h4>We show that state of birth explains a modest amount of variation in AD mortality, approximately 4%, which is consistent with life course theories that suggest that early life conditions can produce old age health disparities. However, we also show that nearly all of the variation from state of birth is explained by state of residence in old age.<h4>Conclusions</h4>These results suggest that later life factors are potentially more consequential targets for intervention in reducing AD mortality and provide some evidence against the importance of macro-level environmental exposures at birth as a core determinant of later AD.
format	article
author	Michael Topping Jinho Kim Jason Fletcher
author_facet	Michael Topping Jinho Kim Jason Fletcher
author_sort	Michael Topping
title	Geographic variation in Alzheimer's disease mortality.
title_short	Geographic variation in Alzheimer's disease mortality.
title_full	Geographic variation in Alzheimer's disease mortality.
title_fullStr	Geographic variation in Alzheimer's disease mortality.
title_full_unstemmed	Geographic variation in Alzheimer's disease mortality.
title_sort	geographic variation in alzheimer's disease mortality.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/4b5d805848e14d9f87a43cf34f798ac5
work_keys_str_mv	AT michaeltopping geographicvariationinalzheimersdiseasemortality AT jinhokim geographicvariationinalzheimersdiseasemortality AT jasonfletcher geographicvariationinalzheimersdiseasemortality
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Geographic variation in Alzheimer's disease mortality.

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