Bimodal antagonism of PKA signalling by ARHGAP36

Protein kinase A (PKA) is a key mediator of cyclic AMP signalling. Here, Eccles et al. show that ARHGAP36 antagonizes PKA by acting as a kinase inhibitor and targeting the catalytic subunit for endolysosomal degradation, thus reducing sensitivity of cells to cAMP and promoting Hedgehog signalling.

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Autores principales:	Rebecca L. Eccles, Maciej T. Czajkowski, Carolin Barth, Paul Markus Müller, Erik McShane, Stephan Grunwald, Patrick Beaudette, Nora Mecklenburg, Rudolf Volkmer, Kerstin Zühlke, Gunnar Dittmar, Matthias Selbach, Annette Hammes, Oliver Daumke, Enno Klussmann, Sylvie Urbé, Oliver Rocks
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b603724ee39452aa970f9812ba07050
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spelling	oai:doaj.org-article:4b603724ee39452aa970f9812ba070502021-12-02T15:34:56ZBimodal antagonism of PKA signalling by ARHGAP3610.1038/ncomms129632041-1723https://doaj.org/article/4b603724ee39452aa970f9812ba070502016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12963https://doaj.org/toc/2041-1723Protein kinase A (PKA) is a key mediator of cyclic AMP signalling. Here, Eccles et al. show that ARHGAP36 antagonizes PKA by acting as a kinase inhibitor and targeting the catalytic subunit for endolysosomal degradation, thus reducing sensitivity of cells to cAMP and promoting Hedgehog signalling.Rebecca L. EcclesMaciej T. CzajkowskiCarolin BarthPaul Markus MüllerErik McShaneStephan GrunwaldPatrick BeaudetteNora MecklenburgRudolf VolkmerKerstin ZühlkeGunnar DittmarMatthias SelbachAnnette HammesOliver DaumkeEnno KlussmannSylvie UrbéOliver RocksNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca L. Eccles Maciej T. Czajkowski Carolin Barth Paul Markus Müller Erik McShane Stephan Grunwald Patrick Beaudette Nora Mecklenburg Rudolf Volkmer Kerstin Zühlke Gunnar Dittmar Matthias Selbach Annette Hammes Oliver Daumke Enno Klussmann Sylvie Urbé Oliver Rocks Bimodal antagonism of PKA signalling by ARHGAP36
description	Protein kinase A (PKA) is a key mediator of cyclic AMP signalling. Here, Eccles et al. show that ARHGAP36 antagonizes PKA by acting as a kinase inhibitor and targeting the catalytic subunit for endolysosomal degradation, thus reducing sensitivity of cells to cAMP and promoting Hedgehog signalling.
format	article
author	Rebecca L. Eccles Maciej T. Czajkowski Carolin Barth Paul Markus Müller Erik McShane Stephan Grunwald Patrick Beaudette Nora Mecklenburg Rudolf Volkmer Kerstin Zühlke Gunnar Dittmar Matthias Selbach Annette Hammes Oliver Daumke Enno Klussmann Sylvie Urbé Oliver Rocks
author_facet	Rebecca L. Eccles Maciej T. Czajkowski Carolin Barth Paul Markus Müller Erik McShane Stephan Grunwald Patrick Beaudette Nora Mecklenburg Rudolf Volkmer Kerstin Zühlke Gunnar Dittmar Matthias Selbach Annette Hammes Oliver Daumke Enno Klussmann Sylvie Urbé Oliver Rocks
author_sort	Rebecca L. Eccles
title	Bimodal antagonism of PKA signalling by ARHGAP36
title_short	Bimodal antagonism of PKA signalling by ARHGAP36
title_full	Bimodal antagonism of PKA signalling by ARHGAP36
title_fullStr	Bimodal antagonism of PKA signalling by ARHGAP36
title_full_unstemmed	Bimodal antagonism of PKA signalling by ARHGAP36
title_sort	bimodal antagonism of pka signalling by arhgap36
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4b603724ee39452aa970f9812ba07050
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Bimodal antagonism of PKA signalling by ARHGAP36

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