Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock

The effect of the liver clock is modified by food entrainment via Bmal1/Clock core machinery. Here the authors show that insulin promotes postprandial Akt-dependent phosphorylation of Bmal1, resulting in association with 14-3-3 and Bmal1 shuttling out of the nucleus, thereby disrupting Bmal1 transcr...

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Autores principales:	Fabin Dang, Xiujie Sun, Xiang Ma, Rong Wu, Deyi Zhang, Yaqiong Chen, Qian Xu, Yuting Wu, Yi Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b62ffc0e73f45a1a3e2a6fa147df23e
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spelling	oai:doaj.org-article:4b62ffc0e73f45a1a3e2a6fa147df23e2021-12-02T17:32:51ZInsulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock10.1038/ncomms126962041-1723https://doaj.org/article/4b62ffc0e73f45a1a3e2a6fa147df23e2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12696https://doaj.org/toc/2041-1723The effect of the liver clock is modified by food entrainment via Bmal1/Clock core machinery. Here the authors show that insulin promotes postprandial Akt-dependent phosphorylation of Bmal1, resulting in association with 14-3-3 and Bmal1 shuttling out of the nucleus, thereby disrupting Bmal1 transcriptional effects on the clock.Fabin DangXiujie SunXiang MaRong WuDeyi ZhangYaqiong ChenQian XuYuting WuYi LiuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fabin Dang Xiujie Sun Xiang Ma Rong Wu Deyi Zhang Yaqiong Chen Qian Xu Yuting Wu Yi Liu Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
description	The effect of the liver clock is modified by food entrainment via Bmal1/Clock core machinery. Here the authors show that insulin promotes postprandial Akt-dependent phosphorylation of Bmal1, resulting in association with 14-3-3 and Bmal1 shuttling out of the nucleus, thereby disrupting Bmal1 transcriptional effects on the clock.
format	article
author	Fabin Dang Xiujie Sun Xiang Ma Rong Wu Deyi Zhang Yaqiong Chen Qian Xu Yuting Wu Yi Liu
author_facet	Fabin Dang Xiujie Sun Xiang Ma Rong Wu Deyi Zhang Yaqiong Chen Qian Xu Yuting Wu Yi Liu
author_sort	Fabin Dang
title	Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
title_short	Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
title_full	Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
title_fullStr	Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
title_full_unstemmed	Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock
title_sort	insulin post-transcriptionally modulates bmal1 protein to affect the hepatic circadian clock
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4b62ffc0e73f45a1a3e2a6fa147df23e
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Insulin post-transcriptionally modulates Bmal1 protein to affect the hepatic circadian clock

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