Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery
Jinfeng Xing, Liandong Deng, Jun Li, Anjie DongDepartment of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of ChinaAbstract: In this study, the transdermal drug delivery properties of D,L-tetrahydropalmati...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2009
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/4b64f7b18bfc490898606bc654c513f5 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:4b64f7b18bfc490898606bc654c513f5 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:4b64f7b18bfc490898606bc654c513f52021-12-02T01:16:05ZAmphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery1176-91141178-2013https://doaj.org/article/4b64f7b18bfc490898606bc654c513f52009-10-01T00:00:00Zhttp://www.dovepress.com/amphiphilic-polyalpha-maleic-anhydride-omega-methoxypolyethylene-glyco-a3643https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Jinfeng Xing, Liandong Deng, Jun Li, Anjie DongDepartment of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of ChinaAbstract: In this study, the transdermal drug delivery properties of D,L-tetrahydropalmatine (THP)-loaded amphiphilic poly{[α-maleic anhydride-ω-methoxy-poly(ethylene glycol)]-co-(ethyl cyanoacrylate)} (PEGECA) graft copolymer nanoparticles (PEGECAT NPs) were evaluated by skin penetration experiments in vitro. The transdermal permeation experiments in vitro were carried out in Franz diffusion cells using THP-loaded PEGECAT NPs as the donor system. Transmission electron microscopy and Fourier transform infrared spectroscopy were used to characterize the receptor fluid. The results indicate that the THP-loaded PEGECAT NPs are able to penetrate the rat skin. Fluorescent microscopy measurements demonstrate that THP-loaded PEGECAT NPs can penetrate the skin not only via appendage routes but also via epidermal routes. This nanotechnology has potential application in transdermal drug delivery. Keywords: poly{[α-maleic anhydride-ω-methoxy-poly(ethylene glycol)]-co-(ethyl cyanoacrylate)}, nanoparticles, transdermal drug delivery, D,L-tetrahydropalmatine Jinfeng XingLiandong DengJun Liet al. Dove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2009, Iss default, Pp 227-232 (2009) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine (General) R5-920 |
| spellingShingle |
Medicine (General) R5-920 Jinfeng Xing Liandong Deng Jun Li et al.  Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery |
| description |
Jinfeng Xing, Liandong Deng, Jun Li, Anjie DongDepartment of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, People’s Republic of ChinaAbstract: In this study, the transdermal drug delivery properties of D,L-tetrahydropalmatine (THP)-loaded amphiphilic poly{[α-maleic anhydride-ω-methoxy-poly(ethylene glycol)]-co-(ethyl cyanoacrylate)} (PEGECA) graft copolymer nanoparticles (PEGECAT NPs) were evaluated by skin penetration experiments in vitro. The transdermal permeation experiments in vitro were carried out in Franz diffusion cells using THP-loaded PEGECAT NPs as the donor system. Transmission electron microscopy and Fourier transform infrared spectroscopy were used to characterize the receptor fluid. The results indicate that the THP-loaded PEGECAT NPs are able to penetrate the rat skin. Fluorescent microscopy measurements demonstrate that THP-loaded PEGECAT NPs can penetrate the skin not only via appendage routes but also via epidermal routes. This nanotechnology has potential application in transdermal drug delivery. Keywords: poly{[α-maleic anhydride-ω-methoxy-poly(ethylene glycol)]-co-(ethyl cyanoacrylate)}, nanoparticles, transdermal drug delivery, D,L-tetrahydropalmatine |
| format |
article |
| author |
Jinfeng Xing Liandong Deng Jun Li et al.  |
| author_facet |
Jinfeng Xing Liandong Deng Jun Li et al.  |
| author_sort |
Jinfeng Xing |
| title |
Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery |
| title_short |
Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery |
| title_full |
Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery |
| title_fullStr |
Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery |
| title_full_unstemmed |
Amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery |
| title_sort |
amphiphilic poly{[α-maleic anhydride-ω-methoxypoly(ethylene glycol)]-co-(ethyl cyanoacrylate)} graft copolymer nanoparticles as carriers for transdermal drug delivery |
| publisher |
Dove Medical Press |
| publishDate |
2009 |
| url |
https://doaj.org/article/4b64f7b18bfc490898606bc654c513f5 |
| work_keys_str_mv |
AT jinfengxing amphiphilicpolyampalphamaleicanhydrideampomegamethoxypolyethyleneglycolcoethylcyanoacrylategraftcopolymernanoparticlesascarriersfortransdermaldrugdelivery AT liandongdeng amphiphilicpolyampalphamaleicanhydrideampomegamethoxypolyethyleneglycolcoethylcyanoacrylategraftcopolymernanoparticlesascarriersfortransdermaldrugdelivery AT junli amphiphilicpolyampalphamaleicanhydrideampomegamethoxypolyethyleneglycolcoethylcyanoacrylategraftcopolymernanoparticlesascarriersfortransdermaldrugdelivery AT etalampnbsp amphiphilicpolyampalphamaleicanhydrideampomegamethoxypolyethyleneglycolcoethylcyanoacrylategraftcopolymernanoparticlesascarriersfortransdermaldrugdelivery |
| _version_ |
1718403197435904000 |