Conservative treatment for late-onset bleb leaks after trabeculectomy with mitomycin C in patients with ocular surface disease

Hideto Sagara,1,2 Tomohiro Iida,2,3 Kimimori Saito,4 Hiroki Noji,2 Masashi Ogasawara,2 Hiroshi Oyamada21The Marui Eye Clinic, Fukushima, 2Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, 3Tokyo Women&#39;s Medical University, Tokyo, 4Matuki Eye Clinic,...

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Autores principales:	Sagara H, Iida T, Saito K, Noji H, Ogasawara M, Oyamada H
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Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
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spelling	oai:doaj.org-article:4b68f166056445d795ec49ebc23cce482021-12-02T03:06:33ZConservative treatment for late-onset bleb leaks after trabeculectomy with mitomycin C in patients with ocular surface disease1177-54671177-5483https://doaj.org/article/4b68f166056445d795ec49ebc23cce482012-08-01T00:00:00Zhttp://www.dovepress.com/conservative-treatment-for-late-onset-bleb-leaks-after-trabeculectomy--a10638https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Hideto Sagara,1,2 Tomohiro Iida,2,3 Kimimori Saito,4 Hiroki Noji,2 Masashi Ogasawara,2 Hiroshi Oyamada21The Marui Eye Clinic, Fukushima, 2Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, 3Tokyo Women&#39;s Medical University, Tokyo, 4Matuki Eye Clinic, Fukushima, JapanBackground: Sodium hyaluronate and autologous serum eye drops are used to treat ocular surface disease (OSD) and are reported to prevent and treat late-onset bleb leaks following trabeculectomy with mitomycin C. In this study, we evaluated the efficacy of a combination of sodium hyaluronate and autologous serum eye drops and treatment for obstructive meibomian gland dysfunction as a therapy for late-onset bleb leaks after trabeculectomy with mitomycin C.Methods: This was a retrospective, interventional, nonsimultaneous study of 12 subjects (12 eyes) of mean age of 64.3 &plusmn; 18.3 years with OSD and apparent late-onset bleb leaks following trabeculectomy with mitomycin C between 1998 and 2008. We compared patients diagnosed with leakages before July 2005, who had been treated with separate eye drop solutions containing 0.1% sodium hyaluronate, 50% autologous serum, and 0.3% ofloxacin (sodium hyaluronate and autologous serum group, n = 7), with patients diagnosed from August 2005 to December 2008, who were treated with a combination of eye drops (0.1% sodium hyaluronate, 50% autologous serum, and 0.08% levofloxacin hydrate) and eyelid massage and warm compresses for obstructive meibomian gland dysfunction (combination eye drop group, n = 5).Results: Leakage was resolved in one patient (14.3%) in the separately treated sodium hyaluronate and autologous serum eye drop group and in five patients (100%) in the combination eye drop group (P = 0.015). The period after resolution of leakage with conservative treatment was 23 months in the one eye in the sodium hyaluronate and autologous serum group and 36&ndash;61 (mean 52.4 &plusmn; 10.1) months in the five eyes in the combination eye drop group.Conclusion: Late-onset bleb leaks following trabeculectomy with mitomycin C can be treated effectively using a combination of sodium hyaluronate and autologous serum eye drops, eyelid massage, and warm compresses. Furthermore, combining eye drops may improve patient adherence to the drug regimen by decreasing the frequency of administration.Keywords: ocular surface disease, bleb leak, trabeculectomy, sodium hyaluronate, autologous serum, meibomian gland dysfunctionSagara HIida TSaito KNoji HOgasawara MOyamada HDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 1273-1279 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Sagara H Iida T Saito K Noji H Ogasawara M Oyamada H Conservative treatment for late-onset bleb leaks after trabeculectomy with mitomycin C in patients with ocular surface disease
description	Hideto Sagara,1,2 Tomohiro Iida,2,3 Kimimori Saito,4 Hiroki Noji,2 Masashi Ogasawara,2 Hiroshi Oyamada21The Marui Eye Clinic, Fukushima, 2Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, 3Tokyo Women&#39;s Medical University, Tokyo, 4Matuki Eye Clinic, Fukushima, JapanBackground: Sodium hyaluronate and autologous serum eye drops are used to treat ocular surface disease (OSD) and are reported to prevent and treat late-onset bleb leaks following trabeculectomy with mitomycin C. In this study, we evaluated the efficacy of a combination of sodium hyaluronate and autologous serum eye drops and treatment for obstructive meibomian gland dysfunction as a therapy for late-onset bleb leaks after trabeculectomy with mitomycin C.Methods: This was a retrospective, interventional, nonsimultaneous study of 12 subjects (12 eyes) of mean age of 64.3 &plusmn; 18.3 years with OSD and apparent late-onset bleb leaks following trabeculectomy with mitomycin C between 1998 and 2008. We compared patients diagnosed with leakages before July 2005, who had been treated with separate eye drop solutions containing 0.1% sodium hyaluronate, 50% autologous serum, and 0.3% ofloxacin (sodium hyaluronate and autologous serum group, n = 7), with patients diagnosed from August 2005 to December 2008, who were treated with a combination of eye drops (0.1% sodium hyaluronate, 50% autologous serum, and 0.08% levofloxacin hydrate) and eyelid massage and warm compresses for obstructive meibomian gland dysfunction (combination eye drop group, n = 5).Results: Leakage was resolved in one patient (14.3%) in the separately treated sodium hyaluronate and autologous serum eye drop group and in five patients (100%) in the combination eye drop group (P = 0.015). The period after resolution of leakage with conservative treatment was 23 months in the one eye in the sodium hyaluronate and autologous serum group and 36&ndash;61 (mean 52.4 &plusmn; 10.1) months in the five eyes in the combination eye drop group.Conclusion: Late-onset bleb leaks following trabeculectomy with mitomycin C can be treated effectively using a combination of sodium hyaluronate and autologous serum eye drops, eyelid massage, and warm compresses. Furthermore, combining eye drops may improve patient adherence to the drug regimen by decreasing the frequency of administration.Keywords: ocular surface disease, bleb leak, trabeculectomy, sodium hyaluronate, autologous serum, meibomian gland dysfunction
format	article
author	Sagara H Iida T Saito K Noji H Ogasawara M Oyamada H
author_facet	Sagara H Iida T Saito K Noji H Ogasawara M Oyamada H
author_sort	Sagara H
title	Conservative treatment for late-onset bleb leaks after trabeculectomy with mitomycin C in patients with ocular surface disease
title_short	Conservative treatment for late-onset bleb leaks after trabeculectomy with mitomycin C in patients with ocular surface disease
title_full	Conservative treatment for late-onset bleb leaks after trabeculectomy with mitomycin C in patients with ocular surface disease
title_fullStr	Conservative treatment for late-onset bleb leaks after trabeculectomy with mitomycin C in patients with ocular surface disease
title_full_unstemmed	Conservative treatment for late-onset bleb leaks after trabeculectomy with mitomycin C in patients with ocular surface disease
title_sort	conservative treatment for late-onset bleb leaks after trabeculectomy with mitomycin c in patients with ocular surface disease
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/4b68f166056445d795ec49ebc23cce48
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Conservative treatment for late-onset bleb leaks after trabeculectomy with mitomycin C in patients with ocular surface disease

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