BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

Mutations of the SWI/SNF chromatin-remodeling complex member SMARCB1 can cause malignant rhaboid tumors. Here the authors report a BRD9-containing SWI/SNF subcomplex that lacks SMARCB1 and its requirement for the survival of rhaboid tumors.

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Autores principales:	Xiaofeng Wang, Su Wang, Emma C. Troisi, Thomas P. Howard, Jeffrey R. Haswell, Bennett K. Wolf, William H. Hawk, Pilar Ramos, Elaine M. Oberlick, Evgeni P. Tzvetkov, Aaron Ross, Francisca Vazquez, William C. Hahn, Peter J. Park, Charles W. M. Roberts
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b69173f717e4efcb19c2a38dcdb58fd
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spelling	oai:doaj.org-article:4b69173f717e4efcb19c2a38dcdb58fd2021-12-02T14:39:19ZBRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors10.1038/s41467-019-09891-72041-1723https://doaj.org/article/4b69173f717e4efcb19c2a38dcdb58fd2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09891-7https://doaj.org/toc/2041-1723Mutations of the SWI/SNF chromatin-remodeling complex member SMARCB1 can cause malignant rhaboid tumors. Here the authors report a BRD9-containing SWI/SNF subcomplex that lacks SMARCB1 and its requirement for the survival of rhaboid tumors.Xiaofeng WangSu WangEmma C. TroisiThomas P. HowardJeffrey R. HaswellBennett K. WolfWilliam H. HawkPilar RamosElaine M. OberlickEvgeni P. TzvetkovAaron RossFrancisca VazquezWilliam C. HahnPeter J. ParkCharles W. M. RobertsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaofeng Wang Su Wang Emma C. Troisi Thomas P. Howard Jeffrey R. Haswell Bennett K. Wolf William H. Hawk Pilar Ramos Elaine M. Oberlick Evgeni P. Tzvetkov Aaron Ross Francisca Vazquez William C. Hahn Peter J. Park Charles W. M. Roberts BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors
description	Mutations of the SWI/SNF chromatin-remodeling complex member SMARCB1 can cause malignant rhaboid tumors. Here the authors report a BRD9-containing SWI/SNF subcomplex that lacks SMARCB1 and its requirement for the survival of rhaboid tumors.
format	article
author	Xiaofeng Wang Su Wang Emma C. Troisi Thomas P. Howard Jeffrey R. Haswell Bennett K. Wolf William H. Hawk Pilar Ramos Elaine M. Oberlick Evgeni P. Tzvetkov Aaron Ross Francisca Vazquez William C. Hahn Peter J. Park Charles W. M. Roberts
author_facet	Xiaofeng Wang Su Wang Emma C. Troisi Thomas P. Howard Jeffrey R. Haswell Bennett K. Wolf William H. Hawk Pilar Ramos Elaine M. Oberlick Evgeni P. Tzvetkov Aaron Ross Francisca Vazquez William C. Hahn Peter J. Park Charles W. M. Roberts
author_sort	Xiaofeng Wang
title	BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors
title_short	BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors
title_full	BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors
title_fullStr	BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors
title_full_unstemmed	BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors
title_sort	brd9 defines a swi/snf sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4b69173f717e4efcb19c2a38dcdb58fd
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BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors

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