Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals.

<h4>Background</h4>The giant panda has an interesting bamboo diet unlike the other species in the order of Carnivora. The umami taste receptor gene T1R1 has been identified as a pseudogene during its genome sequencing project and confirmed using a different giant panda sample. The estima...

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Autores principales:	Ke Jin, Chenyi Xue, Xiaoli Wu, Jinyi Qian, Yong Zhu, Zhen Yang, Takahiro Yonezawa, M James C Crabbe, Ying Cao, Masami Hasegawa, Yang Zhong, Yufang Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b6bff6b7f2d44a58b1efbcdff4cb8b9
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spelling	oai:doaj.org-article:4b6bff6b7f2d44a58b1efbcdff4cb8b92021-11-18T06:49:17ZWhy does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals.1932-620310.1371/journal.pone.0022602https://doaj.org/article/4b6bff6b7f2d44a58b1efbcdff4cb8b92011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21818345/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The giant panda has an interesting bamboo diet unlike the other species in the order of Carnivora. The umami taste receptor gene T1R1 has been identified as a pseudogene during its genome sequencing project and confirmed using a different giant panda sample. The estimated mutation time for this gene is about 4.2 Myr. Such mutation coincided with the giant panda's dietary change and also reinforced its herbivorous life style. However, as this gene is preserved in herbivores such as cow and horse, we need to look for other reasons behind the giant panda's diet switch.<h4>Methodology/principal findings</h4>Since taste is part of the reward properties of food related to its energy and nutrition contents, we did a systematic analysis on those genes involved in the appetite-reward system for the giant panda. We extracted the giant panda sequence information for those genes and compared with the human sequence first and then with seven other species including chimpanzee, mouse, rat, dog, cat, horse, and cow. Orthologs in panda were further analyzed based on the coding region, Kozak consensus sequence, and potential microRNA binding of those genes.<h4>Conclusions/significance</h4>Our results revealed an interesting dopamine metabolic involvement in the panda's food choice. This finding suggests a new direction for molecular evolution studies behind the panda's dietary switch.Ke JinChenyi XueXiaoli WuJinyi QianYong ZhuZhen YangTakahiro YonezawaM James C CrabbeYing CaoMasami HasegawaYang ZhongYufang ZhengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22602 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ke Jin Chenyi Xue Xiaoli Wu Jinyi Qian Yong Zhu Zhen Yang Takahiro Yonezawa M James C Crabbe Ying Cao Masami Hasegawa Yang Zhong Yufang Zheng Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals.
description	<h4>Background</h4>The giant panda has an interesting bamboo diet unlike the other species in the order of Carnivora. The umami taste receptor gene T1R1 has been identified as a pseudogene during its genome sequencing project and confirmed using a different giant panda sample. The estimated mutation time for this gene is about 4.2 Myr. Such mutation coincided with the giant panda's dietary change and also reinforced its herbivorous life style. However, as this gene is preserved in herbivores such as cow and horse, we need to look for other reasons behind the giant panda's diet switch.<h4>Methodology/principal findings</h4>Since taste is part of the reward properties of food related to its energy and nutrition contents, we did a systematic analysis on those genes involved in the appetite-reward system for the giant panda. We extracted the giant panda sequence information for those genes and compared with the human sequence first and then with seven other species including chimpanzee, mouse, rat, dog, cat, horse, and cow. Orthologs in panda were further analyzed based on the coding region, Kozak consensus sequence, and potential microRNA binding of those genes.<h4>Conclusions/significance</h4>Our results revealed an interesting dopamine metabolic involvement in the panda's food choice. This finding suggests a new direction for molecular evolution studies behind the panda's dietary switch.
format	article
author	Ke Jin Chenyi Xue Xiaoli Wu Jinyi Qian Yong Zhu Zhen Yang Takahiro Yonezawa M James C Crabbe Ying Cao Masami Hasegawa Yang Zhong Yufang Zheng
author_facet	Ke Jin Chenyi Xue Xiaoli Wu Jinyi Qian Yong Zhu Zhen Yang Takahiro Yonezawa M James C Crabbe Ying Cao Masami Hasegawa Yang Zhong Yufang Zheng
author_sort	Ke Jin
title	Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals.
title_short	Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals.
title_full	Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals.
title_fullStr	Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals.
title_full_unstemmed	Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals.
title_sort	why does the giant panda eat bamboo? a comparative analysis of appetite-reward-related genes among mammals.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/4b6bff6b7f2d44a58b1efbcdff4cb8b9
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Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals.

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