TRANSCRIPTIONAL FA CTORS FOXP3, GATA-3, PAX-5 AND THEIR COOPERAT IVE INTERACTIONS IN BRONCHIAL ASTHMA

Abstract. The review article summarizes current information about transcriptional factors Fохр3, GATA- 3, РАХ-5 and their cooperative interactions. Predomination of one of these factors leads to production of corresponding cytokines and appropriate changes in T and B cell functions, thus causing dev...

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Autores principales:	V. N. Mineev, L. N. Sorokina, A. V. Eremeeva, M. A. Nyoma, A. S. Bedenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	fохp3 gata-3 рах-5 stat6 bronchial asthma Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4b6c2bdf4ef94f96aa6b1007fb5b36c1
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spelling	oai:doaj.org-article:4b6c2bdf4ef94f96aa6b1007fb5b36c12021-11-18T08:03:43ZTRANSCRIPTIONAL FA CTORS FOXP3, GATA-3, PAX-5 AND THEIR COOPERAT IVE INTERACTIONS IN BRONCHIAL ASTHMA1563-06252313-741X10.15789/1563-0625-2013-4-303-312https://doaj.org/article/4b6c2bdf4ef94f96aa6b1007fb5b36c12014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/636https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The review article summarizes current information about transcriptional factors Fохр3, GATA- 3, РАХ-5 and their cooperative interactions. Predomination of one of these factors leads to production of corresponding cytokines and appropriate changes in T and B cell functions, thus causing development of different inflammatory events and typical symptoms. Focusing the discussion on Foxp3, GATA-3 and PAX- 5 is essential for understanding pathogenesis of inflammatory lung diseases, in particular, bronchial asthma. The data obtained will be helpful in development of novel therapeutic strategies. Mechanisms of cooperative interactions of Fохр3, GATA-3 and РАХ-5, generally, remain poorly understood. In this article, we present modern, sometimes, controversial views on this issue. In particular, we are discussing regulation of Foxp3 expression, molecular interactions affecting production of PAX-5 factor, as well as addressing possible indirect interactions between these transcription factors via implementing GATA-3 and STAT6 functions.V. N. MineevL. N. SorokinaA. V. EremeevaM. A. NyomaA. S. BedenkoSPb RAACIarticlefохp3gata-3рах-5stat6bronchial asthmaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 4, Pp 303-312 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	fохp3 gata-3 рах-5 stat6 bronchial asthma Immunologic diseases. Allergy RC581-607
spellingShingle	fохp3 gata-3 рах-5 stat6 bronchial asthma Immunologic diseases. Allergy RC581-607 V. N. Mineev L. N. Sorokina A. V. Eremeeva M. A. Nyoma A. S. Bedenko TRANSCRIPTIONAL FA CTORS FOXP3, GATA-3, PAX-5 AND THEIR COOPERAT IVE INTERACTIONS IN BRONCHIAL ASTHMA
description	Abstract. The review article summarizes current information about transcriptional factors Fохр3, GATA- 3, РАХ-5 and their cooperative interactions. Predomination of one of these factors leads to production of corresponding cytokines and appropriate changes in T and B cell functions, thus causing development of different inflammatory events and typical symptoms. Focusing the discussion on Foxp3, GATA-3 and PAX- 5 is essential for understanding pathogenesis of inflammatory lung diseases, in particular, bronchial asthma. The data obtained will be helpful in development of novel therapeutic strategies. Mechanisms of cooperative interactions of Fохр3, GATA-3 and РАХ-5, generally, remain poorly understood. In this article, we present modern, sometimes, controversial views on this issue. In particular, we are discussing regulation of Foxp3 expression, molecular interactions affecting production of PAX-5 factor, as well as addressing possible indirect interactions between these transcription factors via implementing GATA-3 and STAT6 functions.
format	article
author	V. N. Mineev L. N. Sorokina A. V. Eremeeva M. A. Nyoma A. S. Bedenko
author_facet	V. N. Mineev L. N. Sorokina A. V. Eremeeva M. A. Nyoma A. S. Bedenko
author_sort	V. N. Mineev
title	TRANSCRIPTIONAL FA CTORS FOXP3, GATA-3, PAX-5 AND THEIR COOPERAT IVE INTERACTIONS IN BRONCHIAL ASTHMA
title_short	TRANSCRIPTIONAL FA CTORS FOXP3, GATA-3, PAX-5 AND THEIR COOPERAT IVE INTERACTIONS IN BRONCHIAL ASTHMA
title_full	TRANSCRIPTIONAL FA CTORS FOXP3, GATA-3, PAX-5 AND THEIR COOPERAT IVE INTERACTIONS IN BRONCHIAL ASTHMA
title_fullStr	TRANSCRIPTIONAL FA CTORS FOXP3, GATA-3, PAX-5 AND THEIR COOPERAT IVE INTERACTIONS IN BRONCHIAL ASTHMA
title_full_unstemmed	TRANSCRIPTIONAL FA CTORS FOXP3, GATA-3, PAX-5 AND THEIR COOPERAT IVE INTERACTIONS IN BRONCHIAL ASTHMA
title_sort	transcriptional fa ctors foxp3, gata-3, pax-5 and their cooperat ive interactions in bronchial asthma
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/4b6c2bdf4ef94f96aa6b1007fb5b36c1
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TRANSCRIPTIONAL FA CTORS FOXP3, GATA-3, PAX-5 AND THEIR COOPERAT IVE INTERACTIONS IN BRONCHIAL ASTHMA

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