Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis

The metabolism of amino acids and the cellular energy sensor AMPK are both connected to mTORC1, but the pathway details have not been well defined. Here, the authors show that glutamine metabolism and mTORC1 have two regulatory connections with relevance to cancer therapeutics design.

Guardado en:

Detalles Bibliográficos
Autores principales:	Clément Bodineau, Mercedes Tomé, Sarah Courtois, Ana S. H. Costa, Marco Sciacovelli, Benoit Rousseau, Elodie Richard, Pierre Vacher, Carlos Parejo-Pérez, Emilie Bessede, Christine Varon, Pierre Soubeyran, Christian Frezza, Piedad del Socorro Murdoch, Victor H. Villar, Raúl V. Durán
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b6d4a30886f478a8c8fe16da840f895
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4b6d4a30886f478a8c8fe16da840f895
record_format	dspace
spelling	oai:doaj.org-article:4b6d4a30886f478a8c8fe16da840f8952021-12-02T16:28:01ZTwo parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis10.1038/s41467-021-25079-42041-1723https://doaj.org/article/4b6d4a30886f478a8c8fe16da840f8952021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25079-4https://doaj.org/toc/2041-1723The metabolism of amino acids and the cellular energy sensor AMPK are both connected to mTORC1, but the pathway details have not been well defined. Here, the authors show that glutamine metabolism and mTORC1 have two regulatory connections with relevance to cancer therapeutics design.Clément BodineauMercedes ToméSarah CourtoisAna S. H. CostaMarco SciacovelliBenoit RousseauElodie RichardPierre VacherCarlos Parejo-PérezEmilie BessedeChristine VaronPierre SoubeyranChristian FrezzaPiedad del Socorro MurdochVictor H. VillarRaúl V. DuránNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clément Bodineau Mercedes Tomé Sarah Courtois Ana S. H. Costa Marco Sciacovelli Benoit Rousseau Elodie Richard Pierre Vacher Carlos Parejo-Pérez Emilie Bessede Christine Varon Pierre Soubeyran Christian Frezza Piedad del Socorro Murdoch Victor H. Villar Raúl V. Durán Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
description	The metabolism of amino acids and the cellular energy sensor AMPK are both connected to mTORC1, but the pathway details have not been well defined. Here, the authors show that glutamine metabolism and mTORC1 have two regulatory connections with relevance to cancer therapeutics design.
format	article
author	Clément Bodineau Mercedes Tomé Sarah Courtois Ana S. H. Costa Marco Sciacovelli Benoit Rousseau Elodie Richard Pierre Vacher Carlos Parejo-Pérez Emilie Bessede Christine Varon Pierre Soubeyran Christian Frezza Piedad del Socorro Murdoch Victor H. Villar Raúl V. Durán
author_facet	Clément Bodineau Mercedes Tomé Sarah Courtois Ana S. H. Costa Marco Sciacovelli Benoit Rousseau Elodie Richard Pierre Vacher Carlos Parejo-Pérez Emilie Bessede Christine Varon Pierre Soubeyran Christian Frezza Piedad del Socorro Murdoch Victor H. Villar Raúl V. Durán
author_sort	Clément Bodineau
title	Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
title_short	Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
title_full	Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
title_fullStr	Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
title_full_unstemmed	Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
title_sort	two parallel pathways connect glutamine metabolism and mtorc1 activity to regulate glutamoptosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4b6d4a30886f478a8c8fe16da840f895
work_keys_str_mv	AT clementbodineau twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT mercedestome twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT sarahcourtois twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT anashcosta twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT marcosciacovelli twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT benoitrousseau twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT elodierichard twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT pierrevacher twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT carlosparejoperez twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT emiliebessede twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT christinevaron twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT pierresoubeyran twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT christianfrezza twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT piedaddelsocorromurdoch twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT victorhvillar twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis AT raulvduran twoparallelpathwaysconnectglutaminemetabolismandmtorc1activitytoregulateglutamoptosis
_version_	1718383928538038272

Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis

Ejemplares similares