The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner

γδ T cells are major producers of IL-17A in response to microbial infection. Here the authors show that a high load of commensal microbes can maintain homeostasis of IL-17A+γδ T cells in the liver via CD1d antigen presentation, with implications for liver diseases.

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Autores principales:	Fenglei Li, Xiaolei Hao, Yongyan Chen, Li Bai, Xiang Gao, Zhexiong Lian, Haiming Wei, Rui Sun, Zhigang Tian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b6e847a5bad48909404d5235889b2d6
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spelling	oai:doaj.org-article:4b6e847a5bad48909404d5235889b2d62021-12-02T14:40:26ZThe microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner10.1038/ncomms138392041-1723https://doaj.org/article/4b6e847a5bad48909404d5235889b2d62017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13839https://doaj.org/toc/2041-1723γδ T cells are major producers of IL-17A in response to microbial infection. Here the authors show that a high load of commensal microbes can maintain homeostasis of IL-17A+γδ T cells in the liver via CD1d antigen presentation, with implications for liver diseases.Fenglei LiXiaolei HaoYongyan ChenLi BaiXiang GaoZhexiong LianHaiming WeiRui SunZhigang TianNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fenglei Li Xiaolei Hao Yongyan Chen Li Bai Xiang Gao Zhexiong Lian Haiming Wei Rui Sun Zhigang Tian The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner
description	γδ T cells are major producers of IL-17A in response to microbial infection. Here the authors show that a high load of commensal microbes can maintain homeostasis of IL-17A+γδ T cells in the liver via CD1d antigen presentation, with implications for liver diseases.
format	article
author	Fenglei Li Xiaolei Hao Yongyan Chen Li Bai Xiang Gao Zhexiong Lian Haiming Wei Rui Sun Zhigang Tian
author_facet	Fenglei Li Xiaolei Hao Yongyan Chen Li Bai Xiang Gao Zhexiong Lian Haiming Wei Rui Sun Zhigang Tian
author_sort	Fenglei Li
title	The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner
title_short	The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner
title_full	The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner
title_fullStr	The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner
title_full_unstemmed	The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner
title_sort	microbiota maintain homeostasis of liver-resident γδt-17 cells in a lipid antigen/cd1d-dependent manner
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4b6e847a5bad48909404d5235889b2d6
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The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner

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