Iridium-catalyzed reductive Ugi-type reactions of tertiary amides

Chemical transformation of amides is normally occurring under harsh conditions. Here, the authors report a mild iridium-catalyzed reductive Ugi-type coupling of tertiary amides, isocyanides and (thio)acetic acid or trimethylsilyl azide to give homologous, bioactive amine products.

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Detalles Bibliográficos
Autores principales:	Lan-Gui Xie, Darren J. Dixon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b7210f119d94a6dbf78675cb6192eb4
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spelling	oai:doaj.org-article:4b7210f119d94a6dbf78675cb6192eb42021-12-02T17:32:35ZIridium-catalyzed reductive Ugi-type reactions of tertiary amides10.1038/s41467-018-05192-72041-1723https://doaj.org/article/4b7210f119d94a6dbf78675cb6192eb42018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05192-7https://doaj.org/toc/2041-1723Chemical transformation of amides is normally occurring under harsh conditions. Here, the authors report a mild iridium-catalyzed reductive Ugi-type coupling of tertiary amides, isocyanides and (thio)acetic acid or trimethylsilyl azide to give homologous, bioactive amine products.Lan-Gui XieDarren J. DixonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lan-Gui Xie Darren J. Dixon Iridium-catalyzed reductive Ugi-type reactions of tertiary amides
description	Chemical transformation of amides is normally occurring under harsh conditions. Here, the authors report a mild iridium-catalyzed reductive Ugi-type coupling of tertiary amides, isocyanides and (thio)acetic acid or trimethylsilyl azide to give homologous, bioactive amine products.
format	article
author	Lan-Gui Xie Darren J. Dixon
author_facet	Lan-Gui Xie Darren J. Dixon
author_sort	Lan-Gui Xie
title	Iridium-catalyzed reductive Ugi-type reactions of tertiary amides
title_short	Iridium-catalyzed reductive Ugi-type reactions of tertiary amides
title_full	Iridium-catalyzed reductive Ugi-type reactions of tertiary amides
title_fullStr	Iridium-catalyzed reductive Ugi-type reactions of tertiary amides
title_full_unstemmed	Iridium-catalyzed reductive Ugi-type reactions of tertiary amides
title_sort	iridium-catalyzed reductive ugi-type reactions of tertiary amides
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4b7210f119d94a6dbf78675cb6192eb4
work_keys_str_mv	AT languixie iridiumcatalyzedreductiveugitypereactionsoftertiaryamides AT darrenjdixon iridiumcatalyzedreductiveugitypereactionsoftertiaryamides
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Iridium-catalyzed reductive Ugi-type reactions of tertiary amides

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