Neuromuscular consequences of an extreme mountain ultra-marathon.

We investigated the physiological consequences of one of the most extreme exercises realized by humans in race conditions: a 166-km mountain ultra-marathon (MUM) with 9500 m of positive and negative elevation change. For this purpose, (i) the fatigue induced by the MUM and (ii) the recovery processe...

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Autores principales:	Guillaume Y Millet, Katja Tomazin, Samuel Verges, Christopher Vincent, Régis Bonnefoy, Renée-Claude Boisson, Laurent Gergelé, Léonard Féasson, Vincent Martin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b729b5ee3b44847ac8faeed9f851cae
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spelling	oai:doaj.org-article:4b729b5ee3b44847ac8faeed9f851cae2021-11-18T06:58:29ZNeuromuscular consequences of an extreme mountain ultra-marathon.1932-620310.1371/journal.pone.0017059https://doaj.org/article/4b729b5ee3b44847ac8faeed9f851cae2011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21364944/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203We investigated the physiological consequences of one of the most extreme exercises realized by humans in race conditions: a 166-km mountain ultra-marathon (MUM) with 9500 m of positive and negative elevation change. For this purpose, (i) the fatigue induced by the MUM and (ii) the recovery processes over two weeks were assessed. Evaluation of neuromuscular function (NMF) and blood markers of muscle damage and inflammation were performed before and immediately following (n = 22), and 2, 5, 9 and 16 days after the MUM (n = 11) in experienced ultra-marathon runners. Large maximal voluntary contraction decreases occurred after MUM (-35% [95% CI: -28 to -42%] and -39% [95% CI: -32 to -46%] for KE and PF, respectively), with alteration of maximal voluntary activation, mainly for KE (-19% [95% CI: -7 to -32%]). Significant modifications in markers of muscle damage and inflammation were observed after the MUM as suggested by the large changes in creatine kinase (from 144 ± 94 to 13,633 ± 12,626 UI L(-1)), myoglobin (from 32 ± 22 to 1,432 ± 1,209 µg L(-1)), and C-Reactive Protein (from <2.0 to 37.7 ± 26.5 mg L(-1)). Moderate to large reductions in maximal compound muscle action potential amplitude, high-frequency doublet force, and low frequency fatigue (index of excitation-contraction coupling alteration) were also observed for both muscle groups. Sixteen days after MUM, NMF had returned to initial values, with most of the recovery process occurring within 9 days of the race. These findings suggest that the large alterations in NMF after an ultra-marathon race are multi-factorial, including failure of excitation-contraction coupling, which has never been described after prolonged running. It is also concluded that as early as two weeks after such an extreme running exercise, maximal force capacities have returned to baseline.Guillaume Y MilletKatja TomazinSamuel VergesChristopher VincentRégis BonnefoyRenée-Claude BoissonLaurent GergeléLéonard FéassonVincent MartinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e17059 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guillaume Y Millet Katja Tomazin Samuel Verges Christopher Vincent Régis Bonnefoy Renée-Claude Boisson Laurent Gergelé Léonard Féasson Vincent Martin Neuromuscular consequences of an extreme mountain ultra-marathon.
description	We investigated the physiological consequences of one of the most extreme exercises realized by humans in race conditions: a 166-km mountain ultra-marathon (MUM) with 9500 m of positive and negative elevation change. For this purpose, (i) the fatigue induced by the MUM and (ii) the recovery processes over two weeks were assessed. Evaluation of neuromuscular function (NMF) and blood markers of muscle damage and inflammation were performed before and immediately following (n = 22), and 2, 5, 9 and 16 days after the MUM (n = 11) in experienced ultra-marathon runners. Large maximal voluntary contraction decreases occurred after MUM (-35% [95% CI: -28 to -42%] and -39% [95% CI: -32 to -46%] for KE and PF, respectively), with alteration of maximal voluntary activation, mainly for KE (-19% [95% CI: -7 to -32%]). Significant modifications in markers of muscle damage and inflammation were observed after the MUM as suggested by the large changes in creatine kinase (from 144 ± 94 to 13,633 ± 12,626 UI L(-1)), myoglobin (from 32 ± 22 to 1,432 ± 1,209 µg L(-1)), and C-Reactive Protein (from <2.0 to 37.7 ± 26.5 mg L(-1)). Moderate to large reductions in maximal compound muscle action potential amplitude, high-frequency doublet force, and low frequency fatigue (index of excitation-contraction coupling alteration) were also observed for both muscle groups. Sixteen days after MUM, NMF had returned to initial values, with most of the recovery process occurring within 9 days of the race. These findings suggest that the large alterations in NMF after an ultra-marathon race are multi-factorial, including failure of excitation-contraction coupling, which has never been described after prolonged running. It is also concluded that as early as two weeks after such an extreme running exercise, maximal force capacities have returned to baseline.
format	article
author	Guillaume Y Millet Katja Tomazin Samuel Verges Christopher Vincent Régis Bonnefoy Renée-Claude Boisson Laurent Gergelé Léonard Féasson Vincent Martin
author_facet	Guillaume Y Millet Katja Tomazin Samuel Verges Christopher Vincent Régis Bonnefoy Renée-Claude Boisson Laurent Gergelé Léonard Féasson Vincent Martin
author_sort	Guillaume Y Millet
title	Neuromuscular consequences of an extreme mountain ultra-marathon.
title_short	Neuromuscular consequences of an extreme mountain ultra-marathon.
title_full	Neuromuscular consequences of an extreme mountain ultra-marathon.
title_fullStr	Neuromuscular consequences of an extreme mountain ultra-marathon.
title_full_unstemmed	Neuromuscular consequences of an extreme mountain ultra-marathon.
title_sort	neuromuscular consequences of an extreme mountain ultra-marathon.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/4b729b5ee3b44847ac8faeed9f851cae
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Neuromuscular consequences of an extreme mountain ultra-marathon.

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