The Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy
Abstract Interleukin 38 (IL-38) is a novel identified cytokine of IL-1 family in which some members are important in inflammation and angiogenesis. However, the role of IL-38 in regulating angiogenesis is unknown. The aim of the present study is to explore the effect of IL-38 on angiogenesis. Oxygen...
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Nature Portfolio
2017
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oai:doaj.org-article:4b7359e77bcb4dbd8ecf0f278ed8e8cc2021-12-02T15:05:10ZThe Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy10.1038/s41598-017-03079-z2045-2322https://doaj.org/article/4b7359e77bcb4dbd8ecf0f278ed8e8cc2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03079-zhttps://doaj.org/toc/2045-2322Abstract Interleukin 38 (IL-38) is a novel identified cytokine of IL-1 family in which some members are important in inflammation and angiogenesis. However, the role of IL-38 in regulating angiogenesis is unknown. The aim of the present study is to explore the effect of IL-38 on angiogenesis. Oxygen-induced retinopathy (OIR) of C57BL/6 J mice was induced by exposure of hyperoxia (75% oxygen) from postnatal day 7 (P7) to P12 and then returned to room air. The mice were injected with IL-38. At P17, neovascular region (tufts) and avascular area of the retinas were analyzed. The data showed that administration of IL-38 in vivo inhibited retinal angiogenesis significantly. Furthermore, the addition of IL-38 to the cell cultures attenuated the proliferation, scratch wound healing and tube formation of vascular endothelial cells induced by VEGF significantly. Our findings suggest that IL-38 is an antiangiogenic cytokine in pathophysiological settings and may have therapeutic potential for angiogenesis related diseases.Jing ZhangRuijuan ZhaoJianping ChenJiayi JinYing YuYunzhe TianWeihua LiWencong WangHongyan ZhouShao Bo SuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) |
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Medicine R Science Q Jing Zhang Ruijuan Zhao Jianping Chen Jiayi Jin Ying Yu Yunzhe Tian Weihua Li Wencong Wang Hongyan Zhou Shao Bo Su The Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy |
| description |
Abstract Interleukin 38 (IL-38) is a novel identified cytokine of IL-1 family in which some members are important in inflammation and angiogenesis. However, the role of IL-38 in regulating angiogenesis is unknown. The aim of the present study is to explore the effect of IL-38 on angiogenesis. Oxygen-induced retinopathy (OIR) of C57BL/6 J mice was induced by exposure of hyperoxia (75% oxygen) from postnatal day 7 (P7) to P12 and then returned to room air. The mice were injected with IL-38. At P17, neovascular region (tufts) and avascular area of the retinas were analyzed. The data showed that administration of IL-38 in vivo inhibited retinal angiogenesis significantly. Furthermore, the addition of IL-38 to the cell cultures attenuated the proliferation, scratch wound healing and tube formation of vascular endothelial cells induced by VEGF significantly. Our findings suggest that IL-38 is an antiangiogenic cytokine in pathophysiological settings and may have therapeutic potential for angiogenesis related diseases. |
| format |
article |
| author |
Jing Zhang Ruijuan Zhao Jianping Chen Jiayi Jin Ying Yu Yunzhe Tian Weihua Li Wencong Wang Hongyan Zhou Shao Bo Su |
| author_facet |
Jing Zhang Ruijuan Zhao Jianping Chen Jiayi Jin Ying Yu Yunzhe Tian Weihua Li Wencong Wang Hongyan Zhou Shao Bo Su |
| author_sort |
Jing Zhang |
| title |
The Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy |
| title_short |
The Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy |
| title_full |
The Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy |
| title_fullStr |
The Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy |
| title_full_unstemmed |
The Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy |
| title_sort |
effect of interleukin 38 on angiogenesis in a model of oxygen-induced retinopathy |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/4b7359e77bcb4dbd8ecf0f278ed8e8cc |
| work_keys_str_mv |
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