NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force

During metaphase, alignment of chromosomes is facilitated by oscillations driven by the chromokinesin Kid. Here Li et al. show that the microtubule-associated protein NuSAP is a novel regulator of Kid, regulating the amplitude and velocity of chromosome oscillation.

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Detalles Bibliográficos
Autores principales: Chenyu Li, Chenyi Xue, Qiaoyun Yang, Boon Chuan Low, Yih-Cherng Liou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/4b78c62498eb4e038a767abf0c375395
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Descripción
Sumario:During metaphase, alignment of chromosomes is facilitated by oscillations driven by the chromokinesin Kid. Here Li et al. show that the microtubule-associated protein NuSAP is a novel regulator of Kid, regulating the amplitude and velocity of chromosome oscillation.