Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer

In eukaryotes the SLC35 family of solute carriers mediate the selective uptake of nucleotide sugars from the cytoplasm into the Endoplasmic Reticulum or Golgi. Here authors report the crystal structure of the yeast GDP-mannose transporter, Vrg4, bound to guanine monophosphate (GMP) revealing the mol...

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Autores principales:	Joanne L. Parker, Robin A. Corey, Phillip J. Stansfeld, Simon Newstead
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b7a5b5b1b9d40119097e2135d10ed60
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spelling	oai:doaj.org-article:4b7a5b5b1b9d40119097e2135d10ed602021-12-02T16:58:27ZStructural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer10.1038/s41467-019-12673-w2041-1723https://doaj.org/article/4b7a5b5b1b9d40119097e2135d10ed602019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12673-whttps://doaj.org/toc/2041-1723In eukaryotes the SLC35 family of solute carriers mediate the selective uptake of nucleotide sugars from the cytoplasm into the Endoplasmic Reticulum or Golgi. Here authors report the crystal structure of the yeast GDP-mannose transporter, Vrg4, bound to guanine monophosphate (GMP) revealing the molecular basis for GMP recognition and transport.Joanne L. ParkerRobin A. CoreyPhillip J. StansfeldSimon NewsteadNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joanne L. Parker Robin A. Corey Phillip J. Stansfeld Simon Newstead Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
description	In eukaryotes the SLC35 family of solute carriers mediate the selective uptake of nucleotide sugars from the cytoplasm into the Endoplasmic Reticulum or Golgi. Here authors report the crystal structure of the yeast GDP-mannose transporter, Vrg4, bound to guanine monophosphate (GMP) revealing the molecular basis for GMP recognition and transport.
format	article
author	Joanne L. Parker Robin A. Corey Phillip J. Stansfeld Simon Newstead
author_facet	Joanne L. Parker Robin A. Corey Phillip J. Stansfeld Simon Newstead
author_sort	Joanne L. Parker
title	Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
title_short	Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
title_full	Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
title_fullStr	Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
title_full_unstemmed	Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
title_sort	structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4b7a5b5b1b9d40119097e2135d10ed60
work_keys_str_mv	AT joannelparker structuralbasisforsubstratespecificityandregulationofnucleotidesugartransportersinthelipidbilayer AT robinacorey structuralbasisforsubstratespecificityandregulationofnucleotidesugartransportersinthelipidbilayer AT phillipjstansfeld structuralbasisforsubstratespecificityandregulationofnucleotidesugartransportersinthelipidbilayer AT simonnewstead structuralbasisforsubstratespecificityandregulationofnucleotidesugartransportersinthelipidbilayer
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Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer

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