Association of polymorphic loci of susceptibility to diabetes mellitus type 2 in various ethnic groups of the Russian Federation

The multifactorial nature of type 2 diabetes mellitus (T2D) was confirmed by numerous researches. The first investigations devoted to molecular-genetic mechanisms of T2D were carried out on the basis of linkage disequilibrium (LD) studying and later the candidate genes of T2D have begun investigated...

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Autores principales:	D. S. Avzaletdinova, T. V. Morugova, L. F. Sharipova, O. V. Kochetova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2021
Materias:	type 2 diabetes mellitus genome wide association study gwas insulin resistance beta-cells genetic polymorphisms Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/4b7a7df23c7f4c3f8c6e4a84adbcbf13
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spelling	oai:doaj.org-article:4b7a7df23c7f4c3f8c6e4a84adbcbf132021-11-14T09:00:23ZAssociation of polymorphic loci of susceptibility to diabetes mellitus type 2 in various ethnic groups of the Russian Federation2072-03512072-037810.14341/DM12531https://doaj.org/article/4b7a7df23c7f4c3f8c6e4a84adbcbf132021-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/12531https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The multifactorial nature of type 2 diabetes mellitus (T2D) was confirmed by numerous researches. The first investigations devoted to molecular-genetic mechanisms of T2D were carried out on the basis of linkage disequilibrium (LD) studying and later the candidate genes of T2D have begun investigated. We have analyzed the literature data including the case-control studies in populations of Russia. There were revealed 33 genes and 65 polymorphic markers in the analyzed works. The analysis of association of T2D in the ethnic groups of Russian Federation was carried out on following genes: ABCC8, ADIPOQ, ADIPOR1, ADIPOR2, C2CD4A/C2CD4A, CDKAL1, CDKN2A/2B, CCL11, CCL20, CCL5, CYBA, FABP2, FTO, GCLC, GPX2, GSTP1, GSTT1, HHEX/IDE, IGF2BP2, IRS1, KCNJ11, KCNQ1, LPL, LRP5, MC4R, PPARG, SLC2A2, SLC30A8, SLC30A8, TCF7L2, TMEM18, WFS1, ZFAND6. The major of studies are replicative, i.e. repeating previous investigations of foreign authors, and were performed on Russian, Tatar and Yakut populations. At the same time not all the loci of genetic susceptibility have demonstrated the association with T2D in the population of Russia. In this work the systematic review of studies of molecular-genetic markers of T2D in the ethnic groups of Russian Federation was made for the first time.D. S. AvzaletdinovaT. V. MorugovaL. F. SharipovaO. V. KochetovaEndocrinology Research Centrearticletype 2 diabetes mellitusgenome wide association study gwasinsulin resistancebeta-cellsgenetic polymorphismsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 24, Iss 3, Pp 262-272 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus genome wide association study gwas insulin resistance beta-cells genetic polymorphisms Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus genome wide association study gwas insulin resistance beta-cells genetic polymorphisms Nutritional diseases. Deficiency diseases RC620-627 D. S. Avzaletdinova T. V. Morugova L. F. Sharipova O. V. Kochetova Association of polymorphic loci of susceptibility to diabetes mellitus type 2 in various ethnic groups of the Russian Federation
description	The multifactorial nature of type 2 diabetes mellitus (T2D) was confirmed by numerous researches. The first investigations devoted to molecular-genetic mechanisms of T2D were carried out on the basis of linkage disequilibrium (LD) studying and later the candidate genes of T2D have begun investigated. We have analyzed the literature data including the case-control studies in populations of Russia. There were revealed 33 genes and 65 polymorphic markers in the analyzed works. The analysis of association of T2D in the ethnic groups of Russian Federation was carried out on following genes: ABCC8, ADIPOQ, ADIPOR1, ADIPOR2, C2CD4A/C2CD4A, CDKAL1, CDKN2A/2B, CCL11, CCL20, CCL5, CYBA, FABP2, FTO, GCLC, GPX2, GSTP1, GSTT1, HHEX/IDE, IGF2BP2, IRS1, KCNJ11, KCNQ1, LPL, LRP5, MC4R, PPARG, SLC2A2, SLC30A8, SLC30A8, TCF7L2, TMEM18, WFS1, ZFAND6. The major of studies are replicative, i.e. repeating previous investigations of foreign authors, and were performed on Russian, Tatar and Yakut populations. At the same time not all the loci of genetic susceptibility have demonstrated the association with T2D in the population of Russia. In this work the systematic review of studies of molecular-genetic markers of T2D in the ethnic groups of Russian Federation was made for the first time.
format	article
author	D. S. Avzaletdinova T. V. Morugova L. F. Sharipova O. V. Kochetova
author_facet	D. S. Avzaletdinova T. V. Morugova L. F. Sharipova O. V. Kochetova
author_sort	D. S. Avzaletdinova
title	Association of polymorphic loci of susceptibility to diabetes mellitus type 2 in various ethnic groups of the Russian Federation
title_short	Association of polymorphic loci of susceptibility to diabetes mellitus type 2 in various ethnic groups of the Russian Federation
title_full	Association of polymorphic loci of susceptibility to diabetes mellitus type 2 in various ethnic groups of the Russian Federation
title_fullStr	Association of polymorphic loci of susceptibility to diabetes mellitus type 2 in various ethnic groups of the Russian Federation
title_full_unstemmed	Association of polymorphic loci of susceptibility to diabetes mellitus type 2 in various ethnic groups of the Russian Federation
title_sort	association of polymorphic loci of susceptibility to diabetes mellitus type 2 in various ethnic groups of the russian federation
publisher	Endocrinology Research Centre
publishDate	2021
url	https://doaj.org/article/4b7a7df23c7f4c3f8c6e4a84adbcbf13
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Association of polymorphic loci of susceptibility to diabetes mellitus type 2 in various ethnic groups of the Russian Federation

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