Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin

Leishmaniasis is a parasitic disease transmitted by the bite of infected sand flies. Here the authors describe an atomic resolution cryo-EM structure of the Leishmania ribosome in complex with the recently approved drug paromomycin (PAR) and highlight conserved elements in the drug binding pocket th...

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Autores principales:	Moran Shalev-Benami, Yan Zhang, Haim Rozenberg, Yuko Nobe, Masato Taoka, Donna Matzov, Ella Zimmerman, Anat Bashan, Toshiaki Isobe, Charles L. Jaffe, Ada Yonath, Georgios Skiniotis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b7b9a6e66c84f36a4b0e669a2a51d88
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spelling	oai:doaj.org-article:4b7b9a6e66c84f36a4b0e669a2a51d882021-12-02T14:40:34ZAtomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin10.1038/s41467-017-01664-42041-1723https://doaj.org/article/4b7b9a6e66c84f36a4b0e669a2a51d882017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01664-4https://doaj.org/toc/2041-1723Leishmaniasis is a parasitic disease transmitted by the bite of infected sand flies. Here the authors describe an atomic resolution cryo-EM structure of the Leishmania ribosome in complex with the recently approved drug paromomycin (PAR) and highlight conserved elements in the drug binding pocket that mediate PAR deleterious effects on the parasite.Moran Shalev-BenamiYan ZhangHaim RozenbergYuko NobeMasato TaokaDonna MatzovElla ZimmermanAnat BashanToshiaki IsobeCharles L. JaffeAda YonathGeorgios SkiniotisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Moran Shalev-Benami Yan Zhang Haim Rozenberg Yuko Nobe Masato Taoka Donna Matzov Ella Zimmerman Anat Bashan Toshiaki Isobe Charles L. Jaffe Ada Yonath Georgios Skiniotis Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin
description	Leishmaniasis is a parasitic disease transmitted by the bite of infected sand flies. Here the authors describe an atomic resolution cryo-EM structure of the Leishmania ribosome in complex with the recently approved drug paromomycin (PAR) and highlight conserved elements in the drug binding pocket that mediate PAR deleterious effects on the parasite.
format	article
author	Moran Shalev-Benami Yan Zhang Haim Rozenberg Yuko Nobe Masato Taoka Donna Matzov Ella Zimmerman Anat Bashan Toshiaki Isobe Charles L. Jaffe Ada Yonath Georgios Skiniotis
author_facet	Moran Shalev-Benami Yan Zhang Haim Rozenberg Yuko Nobe Masato Taoka Donna Matzov Ella Zimmerman Anat Bashan Toshiaki Isobe Charles L. Jaffe Ada Yonath Georgios Skiniotis
author_sort	Moran Shalev-Benami
title	Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin
title_short	Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin
title_full	Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin
title_fullStr	Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin
title_full_unstemmed	Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin
title_sort	atomic resolution snapshot of leishmania ribosome inhibition by the aminoglycoside paromomycin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4b7b9a6e66c84f36a4b0e669a2a51d88
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Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin

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