Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease
Diabetes is a major cause of kidney disease. Here Kikuchi et al. show that phenol sulfate, a gut microbiota-derived metabolite, is increased in diabetic kidney disease and contributes to the pathology by promoting kidney injury, suggesting phenyl sulfate could be used a marker and therapeutic target...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/4b7ee8aaa8cd44e3ba881e3d9e920e28 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:4b7ee8aaa8cd44e3ba881e3d9e920e28 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:4b7ee8aaa8cd44e3ba881e3d9e920e282021-12-02T14:35:55ZGut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease10.1038/s41467-019-09735-42041-1723https://doaj.org/article/4b7ee8aaa8cd44e3ba881e3d9e920e282019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09735-4https://doaj.org/toc/2041-1723Diabetes is a major cause of kidney disease. Here Kikuchi et al. show that phenol sulfate, a gut microbiota-derived metabolite, is increased in diabetic kidney disease and contributes to the pathology by promoting kidney injury, suggesting phenyl sulfate could be used a marker and therapeutic target for the treatment of diabetic kidney disease.Koichi KikuchiDaisuke SaigusaYoshitomi KanemitsuYotaro MatsumotoPaxton ThanaiNaoto SuzukiKoki MiseHiroaki YamaguchiTomohiro NakamuraKei AsajiChikahisa MukawaHiroki TsukamotoToshihiro SatoYoshitsugu OikawaTomoyuki IwasakiYuji OeTomoya TsukimiNoriko N. FukudaHsin-Jung HOFumika Nanto-HaraJiro OguraRitsumi SaitoShizuko NagaoYusuke OhsakiSatoshi ShimadaTakehiro SuzukiTakafumi ToyoharaEikan MishimaHisato ShimaYasutoshi AkiyamaYukako AkiyamaMariko IchijoTetsuro MatsuhashiAkihiro MatsuoYoshiaki OgataChing-Chin YangChitose SuzukiMatthew C. BreeggemannJurgen HeymannMiho ShimizuSusumu OgawaNobuyuki TakahashiTakashi SuzukiYuji OwadaShigeo KureNariyasu ManoTomoyoshi SogaTakashi WadaJeffrey B. KoppShinji FukudaAtsushi HozawaMasayuki YamamotoSadayoshi ItoJun WadaYoshihisa TomiokaTakaaki AbeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Koichi Kikuchi Daisuke Saigusa Yoshitomi Kanemitsu Yotaro Matsumoto Paxton Thanai Naoto Suzuki Koki Mise Hiroaki Yamaguchi Tomohiro Nakamura Kei Asaji Chikahisa Mukawa Hiroki Tsukamoto Toshihiro Sato Yoshitsugu Oikawa Tomoyuki Iwasaki Yuji Oe Tomoya Tsukimi Noriko N. Fukuda Hsin-Jung HO Fumika Nanto-Hara Jiro Ogura Ritsumi Saito Shizuko Nagao Yusuke Ohsaki Satoshi Shimada Takehiro Suzuki Takafumi Toyohara Eikan Mishima Hisato Shima Yasutoshi Akiyama Yukako Akiyama Mariko Ichijo Tetsuro Matsuhashi Akihiro Matsuo Yoshiaki Ogata Ching-Chin Yang Chitose Suzuki Matthew C. Breeggemann Jurgen Heymann Miho Shimizu Susumu Ogawa Nobuyuki Takahashi Takashi Suzuki Yuji Owada Shigeo Kure Nariyasu Mano Tomoyoshi Soga Takashi Wada Jeffrey B. Kopp Shinji Fukuda Atsushi Hozawa Masayuki Yamamoto Sadayoshi Ito Jun Wada Yoshihisa Tomioka Takaaki Abe Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease |
| description |
Diabetes is a major cause of kidney disease. Here Kikuchi et al. show that phenol sulfate, a gut microbiota-derived metabolite, is increased in diabetic kidney disease and contributes to the pathology by promoting kidney injury, suggesting phenyl sulfate could be used a marker and therapeutic target for the treatment of diabetic kidney disease. |
| format |
article |
| author |
Koichi Kikuchi Daisuke Saigusa Yoshitomi Kanemitsu Yotaro Matsumoto Paxton Thanai Naoto Suzuki Koki Mise Hiroaki Yamaguchi Tomohiro Nakamura Kei Asaji Chikahisa Mukawa Hiroki Tsukamoto Toshihiro Sato Yoshitsugu Oikawa Tomoyuki Iwasaki Yuji Oe Tomoya Tsukimi Noriko N. Fukuda Hsin-Jung HO Fumika Nanto-Hara Jiro Ogura Ritsumi Saito Shizuko Nagao Yusuke Ohsaki Satoshi Shimada Takehiro Suzuki Takafumi Toyohara Eikan Mishima Hisato Shima Yasutoshi Akiyama Yukako Akiyama Mariko Ichijo Tetsuro Matsuhashi Akihiro Matsuo Yoshiaki Ogata Ching-Chin Yang Chitose Suzuki Matthew C. Breeggemann Jurgen Heymann Miho Shimizu Susumu Ogawa Nobuyuki Takahashi Takashi Suzuki Yuji Owada Shigeo Kure Nariyasu Mano Tomoyoshi Soga Takashi Wada Jeffrey B. Kopp Shinji Fukuda Atsushi Hozawa Masayuki Yamamoto Sadayoshi Ito Jun Wada Yoshihisa Tomioka Takaaki Abe |
| author_facet |
Koichi Kikuchi Daisuke Saigusa Yoshitomi Kanemitsu Yotaro Matsumoto Paxton Thanai Naoto Suzuki Koki Mise Hiroaki Yamaguchi Tomohiro Nakamura Kei Asaji Chikahisa Mukawa Hiroki Tsukamoto Toshihiro Sato Yoshitsugu Oikawa Tomoyuki Iwasaki Yuji Oe Tomoya Tsukimi Noriko N. Fukuda Hsin-Jung HO Fumika Nanto-Hara Jiro Ogura Ritsumi Saito Shizuko Nagao Yusuke Ohsaki Satoshi Shimada Takehiro Suzuki Takafumi Toyohara Eikan Mishima Hisato Shima Yasutoshi Akiyama Yukako Akiyama Mariko Ichijo Tetsuro Matsuhashi Akihiro Matsuo Yoshiaki Ogata Ching-Chin Yang Chitose Suzuki Matthew C. Breeggemann Jurgen Heymann Miho Shimizu Susumu Ogawa Nobuyuki Takahashi Takashi Suzuki Yuji Owada Shigeo Kure Nariyasu Mano Tomoyoshi Soga Takashi Wada Jeffrey B. Kopp Shinji Fukuda Atsushi Hozawa Masayuki Yamamoto Sadayoshi Ito Jun Wada Yoshihisa Tomioka Takaaki Abe |
| author_sort |
Koichi Kikuchi |
| title |
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease |
| title_short |
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease |
| title_full |
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease |
| title_fullStr |
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease |
| title_full_unstemmed |
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease |
| title_sort |
gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/4b7ee8aaa8cd44e3ba881e3d9e920e28 |
| work_keys_str_mv |
AT koichikikuchi gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT daisukesaigusa gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT yoshitomikanemitsu gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT yotaromatsumoto gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT paxtonthanai gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT naotosuzuki gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT kokimise gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT hiroakiyamaguchi gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT tomohironakamura gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT keiasaji gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT chikahisamukawa gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT hirokitsukamoto gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT toshihirosato gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT yoshitsuguoikawa gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT tomoyukiiwasaki gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT yujioe gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT tomoyatsukimi gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT norikonfukuda gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT hsinjungho gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT fumikanantohara gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT jiroogura gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT ritsumisaito gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT shizukonagao gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT yusukeohsaki gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT satoshishimada gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT takehirosuzuki gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT takafumitoyohara gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT eikanmishima gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT hisatoshima gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT yasutoshiakiyama gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT yukakoakiyama gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT marikoichijo gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT tetsuromatsuhashi gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT akihiromatsuo gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT yoshiakiogata gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT chingchinyang gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT chitosesuzuki gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT matthewcbreeggemann gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT jurgenheymann gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT mihoshimizu gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT susumuogawa gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT nobuyukitakahashi gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT takashisuzuki gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT yujiowada gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT shigeokure gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT nariyasumano gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT tomoyoshisoga gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT takashiwada gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT jeffreybkopp gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT shinjifukuda gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT atsushihozawa gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT masayukiyamamoto gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT sadayoshiito gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT junwada gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT yoshihisatomioka gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease AT takaakiabe gutmicrobiomederivedphenylsulfatecontributestoalbuminuriaindiabetickidneydisease |
| _version_ |
1718391003535114240 |