Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion

Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor processing and potentially altering adult synaptic pl...

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Autores principales:	Silvia Martinelli, Elmira A. Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E. Heinz, Tim Ebert, Jakob Hartmann, Thomas M. Geiger, Michael Döngi, Kathrin Hafner, Max L. Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V. Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W. Turck, Mathias V. Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C. Gassen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b82f8ddb5c141baac1137b7deee6057
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spelling	oai:doaj.org-article:4b82f8ddb5c141baac1137b7deee60572021-12-02T16:13:38ZStress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion10.1038/s41467-021-24810-52041-1723https://doaj.org/article/4b82f8ddb5c141baac1137b7deee60572021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24810-5https://doaj.org/toc/2041-1723Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor processing and potentially altering adult synaptic plasticity.Silvia MartinelliElmira A. AnderzhanovaThomas BajajSvenja WiechmannFrederik DethloffKatja WeckmannDaniel E. HeinzTim EbertJakob HartmannThomas M. GeigerMichael DöngiKathrin HafnerMax L. PöhlmannLee JollansAlexandra PhilipsenSusanne V. SchmidtUlrike SchmidtGiuseppina MaccarroneValentin SteinFelix HauschChristoph W. TurckMathias V. SchmidtAnne-Kathrin GellnerBernhard KusterNils C. GassenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Silvia Martinelli Elmira A. Anderzhanova Thomas Bajaj Svenja Wiechmann Frederik Dethloff Katja Weckmann Daniel E. Heinz Tim Ebert Jakob Hartmann Thomas M. Geiger Michael Döngi Kathrin Hafner Max L. Pöhlmann Lee Jollans Alexandra Philipsen Susanne V. Schmidt Ulrike Schmidt Giuseppina Maccarrone Valentin Stein Felix Hausch Christoph W. Turck Mathias V. Schmidt Anne-Kathrin Gellner Bernhard Kuster Nils C. Gassen Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
description	Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor processing and potentially altering adult synaptic plasticity.
format	article
author	Silvia Martinelli Elmira A. Anderzhanova Thomas Bajaj Svenja Wiechmann Frederik Dethloff Katja Weckmann Daniel E. Heinz Tim Ebert Jakob Hartmann Thomas M. Geiger Michael Döngi Kathrin Hafner Max L. Pöhlmann Lee Jollans Alexandra Philipsen Susanne V. Schmidt Ulrike Schmidt Giuseppina Maccarrone Valentin Stein Felix Hausch Christoph W. Turck Mathias V. Schmidt Anne-Kathrin Gellner Bernhard Kuster Nils C. Gassen
author_facet	Silvia Martinelli Elmira A. Anderzhanova Thomas Bajaj Svenja Wiechmann Frederik Dethloff Katja Weckmann Daniel E. Heinz Tim Ebert Jakob Hartmann Thomas M. Geiger Michael Döngi Kathrin Hafner Max L. Pöhlmann Lee Jollans Alexandra Philipsen Susanne V. Schmidt Ulrike Schmidt Giuseppina Maccarrone Valentin Stein Felix Hausch Christoph W. Turck Mathias V. Schmidt Anne-Kathrin Gellner Bernhard Kuster Nils C. Gassen
author_sort	Silvia Martinelli
title	Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
title_short	Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
title_full	Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
title_fullStr	Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
title_full_unstemmed	Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
title_sort	stress-primed secretory autophagy promotes extracellular bdnf maturation by enhancing mmp9 secretion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4b82f8ddb5c141baac1137b7deee6057
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Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion

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