RELATIONSHIP BETWEEN SERUM LEVEL OF IONIZED CALCIUM, MAGNESIUM, PHOSPHATE, VITAMIN D AND PARATHYROID HORMONE WITH STAGES OF CKD

Background: Chronic kidney disease is defined as either damage or a decreased Glomerular Filtration Rate of less than 60ml/min/1.73m2 for 3 or more months. There is destruction of renal mass with irreversible sclerosis and loss of nephron leading to a progressive decline in GFR.Secondary hyperparath...

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Autores principales:	Mohammed A, Suleiman H.M, Yusuf R, Aliyu I.S, Ibrahim A, Jibril M.E, Manu A
Formato:	article
Lenguaje:	EN
Publicado:	Ntec Specialist 2020
Materias:	chronic kidney disease calcium phosphate vitamin d magnesium parathyroid hormone Medicine (General) R5-920 Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/4b8725dcd3f146dba4dbebc9c224fa5a
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spelling	oai:doaj.org-article:4b8725dcd3f146dba4dbebc9c224fa5a2021-11-12T13:41:44ZRELATIONSHIP BETWEEN SERUM LEVEL OF IONIZED CALCIUM, MAGNESIUM, PHOSPHATE, VITAMIN D AND PARATHYROID HORMONE WITH STAGES OF CKD2006-47722714-242610.36020/kjms.2020.1401.007https://doaj.org/article/4b8725dcd3f146dba4dbebc9c224fa5a2020-01-01T00:00:00Zhttps://kjmsmedicaljournal.com/wp-content/uploads/2020/07/7.-Mohammed-A-et-al-vol14no1.pdfhttps://doaj.org/toc/2006-4772https://doaj.org/toc/2714-2426Background: Chronic kidney disease is defined as either damage or a decreased Glomerular Filtration Rate of less than 60ml/min/1.73m2 for 3 or more months. There is destruction of renal mass with irreversible sclerosis and loss of nephron leading to a progressive decline in GFR.Secondary hyperparathyroidism, hyperphosphataemia, hypocalcaemia and vitamin-D deficiency are common complications of CKD. Objective: To determine relationship between serum level of ionised calcium, magnesium, phosphate, vitamin-D and parathyroid hormone with stages of CKD. Method: This study was conducted at ABUTH Zaria. 125 consecutive adult patients in various stages of CKD who presented were enrolled and 125 apparently healthy matched for sex and age controls were also recruited. Results: 9% of patients were in stage-1, 16% in stage-2, 22% in stage-3, 12% in stage-4 and 41% in stage-5. Serum ionised calcium, vitamin-D and eCrCl showed a progressive decline as the stage of CKD advances, while serum phosphate, creatinine and iPTH showed a progressive increase as the stage of CKD advances. Changes in serum magnesium showed a slight change with advancing stages of CKD. The difference in mean serum levels of calcium, phosphorus, vitamin-D, parathyroid hormone, creatinine and eCrCl with different stages of CKD were statistically significant. eCrCl correlated negatively with phosphate and iPTH while serum creatinine correlated negatively with calcium and positively with phosphate and iPTH. Conclusion: Majority of CKD patients were in late stage. Correlation of analytes with stages was more in late stages and biochemical derangements occurred in late, rather than early stages of CKDMohammed ASuleiman H.MYusuf RAliyu I.SIbrahim AJibril M.EManu ANtec Specialistarticlechronic kidney diseasecalciumphosphatevitamin dmagnesiumparathyroid hormoneMedicine (General)R5-920DentistryRK1-715ENKanem Journal of Medical Sciences, Vol 14, Iss 1, Pp 50-55 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic kidney disease calcium phosphate vitamin d magnesium parathyroid hormone Medicine (General) R5-920 Dentistry RK1-715
spellingShingle	chronic kidney disease calcium phosphate vitamin d magnesium parathyroid hormone Medicine (General) R5-920 Dentistry RK1-715 Mohammed A Suleiman H.M Yusuf R Aliyu I.S Ibrahim A Jibril M.E Manu A RELATIONSHIP BETWEEN SERUM LEVEL OF IONIZED CALCIUM, MAGNESIUM, PHOSPHATE, VITAMIN D AND PARATHYROID HORMONE WITH STAGES OF CKD
description	Background: Chronic kidney disease is defined as either damage or a decreased Glomerular Filtration Rate of less than 60ml/min/1.73m2 for 3 or more months. There is destruction of renal mass with irreversible sclerosis and loss of nephron leading to a progressive decline in GFR.Secondary hyperparathyroidism, hyperphosphataemia, hypocalcaemia and vitamin-D deficiency are common complications of CKD. Objective: To determine relationship between serum level of ionised calcium, magnesium, phosphate, vitamin-D and parathyroid hormone with stages of CKD. Method: This study was conducted at ABUTH Zaria. 125 consecutive adult patients in various stages of CKD who presented were enrolled and 125 apparently healthy matched for sex and age controls were also recruited. Results: 9% of patients were in stage-1, 16% in stage-2, 22% in stage-3, 12% in stage-4 and 41% in stage-5. Serum ionised calcium, vitamin-D and eCrCl showed a progressive decline as the stage of CKD advances, while serum phosphate, creatinine and iPTH showed a progressive increase as the stage of CKD advances. Changes in serum magnesium showed a slight change with advancing stages of CKD. The difference in mean serum levels of calcium, phosphorus, vitamin-D, parathyroid hormone, creatinine and eCrCl with different stages of CKD were statistically significant. eCrCl correlated negatively with phosphate and iPTH while serum creatinine correlated negatively with calcium and positively with phosphate and iPTH. Conclusion: Majority of CKD patients were in late stage. Correlation of analytes with stages was more in late stages and biochemical derangements occurred in late, rather than early stages of CKD
format	article
author	Mohammed A Suleiman H.M Yusuf R Aliyu I.S Ibrahim A Jibril M.E Manu A
author_facet	Mohammed A Suleiman H.M Yusuf R Aliyu I.S Ibrahim A Jibril M.E Manu A
author_sort	Mohammed A
title	RELATIONSHIP BETWEEN SERUM LEVEL OF IONIZED CALCIUM, MAGNESIUM, PHOSPHATE, VITAMIN D AND PARATHYROID HORMONE WITH STAGES OF CKD
title_short	RELATIONSHIP BETWEEN SERUM LEVEL OF IONIZED CALCIUM, MAGNESIUM, PHOSPHATE, VITAMIN D AND PARATHYROID HORMONE WITH STAGES OF CKD
title_full	RELATIONSHIP BETWEEN SERUM LEVEL OF IONIZED CALCIUM, MAGNESIUM, PHOSPHATE, VITAMIN D AND PARATHYROID HORMONE WITH STAGES OF CKD
title_fullStr	RELATIONSHIP BETWEEN SERUM LEVEL OF IONIZED CALCIUM, MAGNESIUM, PHOSPHATE, VITAMIN D AND PARATHYROID HORMONE WITH STAGES OF CKD
title_full_unstemmed	RELATIONSHIP BETWEEN SERUM LEVEL OF IONIZED CALCIUM, MAGNESIUM, PHOSPHATE, VITAMIN D AND PARATHYROID HORMONE WITH STAGES OF CKD
title_sort	relationship between serum level of ionized calcium, magnesium, phosphate, vitamin d and parathyroid hormone with stages of ckd
publisher	Ntec Specialist
publishDate	2020
url	https://doaj.org/article/4b8725dcd3f146dba4dbebc9c224fa5a
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RELATIONSHIP BETWEEN SERUM LEVEL OF IONIZED CALCIUM, MAGNESIUM, PHOSPHATE, VITAMIN D AND PARATHYROID HORMONE WITH STAGES OF CKD

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