An atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations.

<h4>Background</h4>In South America, the highest incidence of primary liver cancer is observed in Peru. However, national estimations on hepatocellular carcinoma incidence and mortality are approximated using aggregated data from surrounding countries. Thus, there is a lack of tangible i...

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Autores principales:	Stéphane Bertani, Pascal Pineau, Sebastian Loli, Julien Moura, Mirko Zimic, Eric Deharo, Eloy Ruiz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b877a47dc97410999266bbe18509755
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spelling	oai:doaj.org-article:4b877a47dc97410999266bbe185097552021-11-18T07:39:23ZAn atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations.1932-620310.1371/journal.pone.0067756https://doaj.org/article/4b877a47dc97410999266bbe185097552013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23840771/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>In South America, the highest incidence of primary liver cancer is observed in Peru. However, national estimations on hepatocellular carcinoma incidence and mortality are approximated using aggregated data from surrounding countries. Thus, there is a lack of tangible information from Peru that impairs an accurate description of the local incidence, presentation, and outcomes of hepatocellular carcinoma. The present study attempts to fill this gap and assesses the clinical epidemiology of hepatocellular carcinoma in this country.<h4>Methods</h4>A retrospective cohort study was conducted by analysing the medical charts of 1,541 patients with hepatocellular carcinoma admitted between 1997 and 2010 at the Peruvian national institute for cancer. The medical records including liver function, serologic status, and tumor pathology and stage were monitored. Statistical analyses were performed in order to characterize tumor presentation according to demographic features, risk factors, and regional origin.<h4>Results</h4>Surprisingly, the age distribution of the patient population displayed bimodality corresponding to two distinct age-based subpopulations. While an older group was in keeping with the age range observed for hepatocellular carcinoma around the world, a younger population displayed an abnormally juvenile mean age of 25.5 years old. In addition, each subpopulation displayed age-specific pathophysiological and clinical characteristics.<h4>Conclusions</h4>The analysis suggests two different age-specific natural histories of hepatocellular carcinoma in the Peruvian patient population. This otherwise unusual tumor process that is ongoing in younger patients leads to the hypothesis that there may be a Peru-endemic risk factor driving hepatocarcinogenesis in the local population.Stéphane BertaniPascal PineauSebastian LoliJulien MouraMirko ZimicEric DeharoEloy RuizPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e67756 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stéphane Bertani Pascal Pineau Sebastian Loli Julien Moura Mirko Zimic Eric Deharo Eloy Ruiz An atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations.
description	<h4>Background</h4>In South America, the highest incidence of primary liver cancer is observed in Peru. However, national estimations on hepatocellular carcinoma incidence and mortality are approximated using aggregated data from surrounding countries. Thus, there is a lack of tangible information from Peru that impairs an accurate description of the local incidence, presentation, and outcomes of hepatocellular carcinoma. The present study attempts to fill this gap and assesses the clinical epidemiology of hepatocellular carcinoma in this country.<h4>Methods</h4>A retrospective cohort study was conducted by analysing the medical charts of 1,541 patients with hepatocellular carcinoma admitted between 1997 and 2010 at the Peruvian national institute for cancer. The medical records including liver function, serologic status, and tumor pathology and stage were monitored. Statistical analyses were performed in order to characterize tumor presentation according to demographic features, risk factors, and regional origin.<h4>Results</h4>Surprisingly, the age distribution of the patient population displayed bimodality corresponding to two distinct age-based subpopulations. While an older group was in keeping with the age range observed for hepatocellular carcinoma around the world, a younger population displayed an abnormally juvenile mean age of 25.5 years old. In addition, each subpopulation displayed age-specific pathophysiological and clinical characteristics.<h4>Conclusions</h4>The analysis suggests two different age-specific natural histories of hepatocellular carcinoma in the Peruvian patient population. This otherwise unusual tumor process that is ongoing in younger patients leads to the hypothesis that there may be a Peru-endemic risk factor driving hepatocarcinogenesis in the local population.
format	article
author	Stéphane Bertani Pascal Pineau Sebastian Loli Julien Moura Mirko Zimic Eric Deharo Eloy Ruiz
author_facet	Stéphane Bertani Pascal Pineau Sebastian Loli Julien Moura Mirko Zimic Eric Deharo Eloy Ruiz
author_sort	Stéphane Bertani
title	An atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations.
title_short	An atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations.
title_full	An atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations.
title_fullStr	An atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations.
title_full_unstemmed	An atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations.
title_sort	atypical age-specific pattern of hepatocellular carcinoma in peru: a threat for andean populations.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4b877a47dc97410999266bbe18509755
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An atypical age-specific pattern of hepatocellular carcinoma in Peru: a threat for Andean populations.

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