Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

FK506 is a potential antifungal compound that inhibits calcineurin, but it also has immunosuppressive activity. Here, Juvvadi et al. report the structure of FK506 in complex with the FK506-binding protein FKPB12 and calcineurin, and design a less immunosuppresive FK506 analog with antifungal activit...

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Autores principales: Praveen R. Juvvadi, David Fox, Benjamin G. Bobay, Michael J. Hoy, Sophie M. C. Gobeil, Ronald A. Venters, Zanetta Chang, Jackie J. Lin, Anna Floyd Averette, D. Christopher Cole, Blake C. Barrington, Joshua D. Wheaton, Maria Ciofani, Michael Trzoss, Xiaoming Li, Soo Chan Lee, Ying-Lien Chen, Mitchell Mutz, Leonard D. Spicer, Maria A. Schumacher, Joseph Heitman, William J. Steinbach
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/4b8d65315776423982c1bea6612cead9
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spelling oai:doaj.org-article:4b8d65315776423982c1bea6612cead92021-12-02T16:58:25ZHarnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents10.1038/s41467-019-12199-12041-1723https://doaj.org/article/4b8d65315776423982c1bea6612cead92019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12199-1https://doaj.org/toc/2041-1723FK506 is a potential antifungal compound that inhibits calcineurin, but it also has immunosuppressive activity. Here, Juvvadi et al. report the structure of FK506 in complex with the FK506-binding protein FKPB12 and calcineurin, and design a less immunosuppresive FK506 analog with antifungal activity in mice.Praveen R. JuvvadiDavid FoxBenjamin G. BobayMichael J. HoySophie M. C. GobeilRonald A. VentersZanetta ChangJackie J. LinAnna Floyd AveretteD. Christopher ColeBlake C. BarringtonJoshua D. WheatonMaria CiofaniMichael TrzossXiaoming LiSoo Chan LeeYing-Lien ChenMitchell MutzLeonard D. SpicerMaria A. SchumacherJoseph HeitmanWilliam J. SteinbachNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Praveen R. Juvvadi
David Fox
Benjamin G. Bobay
Michael J. Hoy
Sophie M. C. Gobeil
Ronald A. Venters
Zanetta Chang
Jackie J. Lin
Anna Floyd Averette
D. Christopher Cole
Blake C. Barrington
Joshua D. Wheaton
Maria Ciofani
Michael Trzoss
Xiaoming Li
Soo Chan Lee
Ying-Lien Chen
Mitchell Mutz
Leonard D. Spicer
Maria A. Schumacher
Joseph Heitman
William J. Steinbach
Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
description FK506 is a potential antifungal compound that inhibits calcineurin, but it also has immunosuppressive activity. Here, Juvvadi et al. report the structure of FK506 in complex with the FK506-binding protein FKPB12 and calcineurin, and design a less immunosuppresive FK506 analog with antifungal activity in mice.
format article
author Praveen R. Juvvadi
David Fox
Benjamin G. Bobay
Michael J. Hoy
Sophie M. C. Gobeil
Ronald A. Venters
Zanetta Chang
Jackie J. Lin
Anna Floyd Averette
D. Christopher Cole
Blake C. Barrington
Joshua D. Wheaton
Maria Ciofani
Michael Trzoss
Xiaoming Li
Soo Chan Lee
Ying-Lien Chen
Mitchell Mutz
Leonard D. Spicer
Maria A. Schumacher
Joseph Heitman
William J. Steinbach
author_facet Praveen R. Juvvadi
David Fox
Benjamin G. Bobay
Michael J. Hoy
Sophie M. C. Gobeil
Ronald A. Venters
Zanetta Chang
Jackie J. Lin
Anna Floyd Averette
D. Christopher Cole
Blake C. Barrington
Joshua D. Wheaton
Maria Ciofani
Michael Trzoss
Xiaoming Li
Soo Chan Lee
Ying-Lien Chen
Mitchell Mutz
Leonard D. Spicer
Maria A. Schumacher
Joseph Heitman
William J. Steinbach
author_sort Praveen R. Juvvadi
title Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
title_short Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
title_full Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
title_fullStr Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
title_full_unstemmed Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
title_sort harnessing calcineurin-fk506-fkbp12 crystal structures from invasive fungal pathogens to develop antifungal agents
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/4b8d65315776423982c1bea6612cead9
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