A Novel Predictive Model Associated with Osteosarcoma Metastasis

Han Zhang,1,2 Guanhong Chen,2 Xiajie Lyu,3 Chun Rong,4 Yingzhen Wang,1 Ying Xu,2 Chengyu Lyu1 1Department of Orthopaedics, The Affiliated Hospital of Qingdao University, Qingdao City, Shandong Province, People’s Republic of China; 2Department of Orthopaedics, Shanxian Central Hospital, Heze City, Sh...

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Autores principales:	Zhang H, Chen G, Lyu X, Rong C, Wang Y, Xu Y, Lyu C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	lncrnas osteosarcoma tumor metastasis prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4b8ffc3328154d758aa779ac26a9b6f4
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spelling	oai:doaj.org-article:4b8ffc3328154d758aa779ac26a9b6f42021-11-09T18:40:35ZA Novel Predictive Model Associated with Osteosarcoma Metastasis1179-1322https://doaj.org/article/4b8ffc3328154d758aa779ac26a9b6f42021-11-01T00:00:00Zhttps://www.dovepress.com/a-novel-predictive-model-associated-with-osteosarcoma-metastasis-peer-reviewed-fulltext-article-CMARhttps://doaj.org/toc/1179-1322Han Zhang,1,2 Guanhong Chen,2 Xiajie Lyu,3 Chun Rong,4 Yingzhen Wang,1 Ying Xu,2 Chengyu Lyu1 1Department of Orthopaedics, The Affiliated Hospital of Qingdao University, Qingdao City, Shandong Province, People’s Republic of China; 2Department of Orthopaedics, Shanxian Central Hospital, Heze City, Shandong Province, People’s Republic of China; 3Weifang Medical University, Weifang, Shandong, People’s Republic of China; 4Department of Operation Room, The Affiliated Hospital of Qingdao University, Qingdao City, Shandong Province, People’s Republic of ChinaCorrespondence: Chengyu Lyu Email 18266390138@163.comPurpose: Long non-coding RNAs (lncRNAs) have diverse roles in modulating gene expression on both transcriptional and translational levels, but their involvement in osteosarcoma (OS) metastasis remains unknown.Patients and Methods: Transcriptional and clinical data were downloaded from TARGET datasets. A total of seven lncRNAs screened by univariate cox regression, lasso regression, and multivariate cox regression analysis were used to establish the OS metastasis model. The area under the receiver operating characteristic curve (AUC) was used to evaluate the model.Results: The established model showed exceptional predictive performance (1 year: AUC = 0.92, 95% Cl = 0.83– 0.99; 3 years: AUC = 0.87, 95% Cl = 0.79– 0.96; 5 years: AUC = 0.86, 95% Cl = 0.76– 0.96). Patients in the high group had a poor survival outcome than those in the low group (p < 0.0001). GSEA analysis revealed that “NOTCH_SIGNALING” and “WNT_BETA_CATENIN_SIGNALING” were significantly enriched and that resting dendritic cells were associated with AL512422.1, AL357507.1, and AC006033.2 (p < 0.05).Conclusion: Based on seven prognosis-related lncRNAs, we constructed a novel model with high reliability and accuracy for predicting metastasis in OS patients.Keywords: lncRNAs, osteosarcoma, tumor metastasis, prognosisZhang HChen GLyu XRong CWang YXu YLyu CDove Medical Pressarticlelncrnasosteosarcomatumor metastasisprognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Management and Research, Vol Volume 13, Pp 8411-8423 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lncrnas osteosarcoma tumor metastasis prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	lncrnas osteosarcoma tumor metastasis prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Zhang H Chen G Lyu X Rong C Wang Y Xu Y Lyu C A Novel Predictive Model Associated with Osteosarcoma Metastasis
description	Han Zhang,1,2 Guanhong Chen,2 Xiajie Lyu,3 Chun Rong,4 Yingzhen Wang,1 Ying Xu,2 Chengyu Lyu1 1Department of Orthopaedics, The Affiliated Hospital of Qingdao University, Qingdao City, Shandong Province, People’s Republic of China; 2Department of Orthopaedics, Shanxian Central Hospital, Heze City, Shandong Province, People’s Republic of China; 3Weifang Medical University, Weifang, Shandong, People’s Republic of China; 4Department of Operation Room, The Affiliated Hospital of Qingdao University, Qingdao City, Shandong Province, People’s Republic of ChinaCorrespondence: Chengyu Lyu Email 18266390138@163.comPurpose: Long non-coding RNAs (lncRNAs) have diverse roles in modulating gene expression on both transcriptional and translational levels, but their involvement in osteosarcoma (OS) metastasis remains unknown.Patients and Methods: Transcriptional and clinical data were downloaded from TARGET datasets. A total of seven lncRNAs screened by univariate cox regression, lasso regression, and multivariate cox regression analysis were used to establish the OS metastasis model. The area under the receiver operating characteristic curve (AUC) was used to evaluate the model.Results: The established model showed exceptional predictive performance (1 year: AUC = 0.92, 95% Cl = 0.83– 0.99; 3 years: AUC = 0.87, 95% Cl = 0.79– 0.96; 5 years: AUC = 0.86, 95% Cl = 0.76– 0.96). Patients in the high group had a poor survival outcome than those in the low group (p < 0.0001). GSEA analysis revealed that “NOTCH_SIGNALING” and “WNT_BETA_CATENIN_SIGNALING” were significantly enriched and that resting dendritic cells were associated with AL512422.1, AL357507.1, and AC006033.2 (p < 0.05).Conclusion: Based on seven prognosis-related lncRNAs, we constructed a novel model with high reliability and accuracy for predicting metastasis in OS patients.Keywords: lncRNAs, osteosarcoma, tumor metastasis, prognosis
format	article
author	Zhang H Chen G Lyu X Rong C Wang Y Xu Y Lyu C
author_facet	Zhang H Chen G Lyu X Rong C Wang Y Xu Y Lyu C
author_sort	Zhang H
title	A Novel Predictive Model Associated with Osteosarcoma Metastasis
title_short	A Novel Predictive Model Associated with Osteosarcoma Metastasis
title_full	A Novel Predictive Model Associated with Osteosarcoma Metastasis
title_fullStr	A Novel Predictive Model Associated with Osteosarcoma Metastasis
title_full_unstemmed	A Novel Predictive Model Associated with Osteosarcoma Metastasis
title_sort	novel predictive model associated with osteosarcoma metastasis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/4b8ffc3328154d758aa779ac26a9b6f4
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A Novel Predictive Model Associated with Osteosarcoma Metastasis

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