Apolipoprotein B/A1 ratio as a potential marker of cardiovascular risk in women

Background: There has been a significant steady rise in the prevalence of cardiovascular disease (CVD) among Nigerian women within the last decade. The balance between pro-atherogenic particles and antiatherogenic particles has been markedly reflected in the apolipoprotein B/A1 ratio (Apo B/A1), and...

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Autores principales:	Olufisayo Gabriel Ayoade, Sarah Ifreke Essien, Oyebola Sonuga
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	apolipoprotein b/a1 ratio cardiovascular disease dyslipidemia Medicine R
Acceso en línea:	https://doaj.org/article/4b90a1c0630640a1a618b82792c60476
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spelling	oai:doaj.org-article:4b90a1c0630640a1a618b82792c604762021-11-12T11:14:59ZApolipoprotein B/A1 ratio as a potential marker of cardiovascular risk in women2321-668910.4103/smj.smj_62_20https://doaj.org/article/4b90a1c0630640a1a618b82792c604762021-01-01T00:00:00Zhttp://www.smjonline.org/article.asp?issn=1118-8561;year=2021;volume=24;issue=3;spage=99;epage=103;aulast=Ayoadehttps://doaj.org/toc/2321-6689Background: There has been a significant steady rise in the prevalence of cardiovascular disease (CVD) among Nigerian women within the last decade. The balance between pro-atherogenic particles and antiatherogenic particles has been markedly reflected in the apolipoprotein B/A1 ratio (Apo B/A1), and this ratio has been shown to be the strongest single lipoprotein-related cardiovascular risk factor. The cutoff value for the apo B/A1 ratio that defines high cardiovascular risk has been proposed to be 0.8 for women. This study is to determine the apo B/A1 ratio in apparently healthy Nigerian women and to evaluate the relationship of this ratio with other lipid indices. Methods: A total of 161 apparently healthy female adults between the ages of 30 and 66 years were selected for this study over a period of 6 months. Plasma total cholesterols (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) were measured using the enzymatic methods, whereas low-density lipoprotein cholesterol (LDL-C) was calculated using the Friedewald formula. Apolipoprotein A1 and B were determined using immunoturbidimetry methods. Results: The mean of plasma apo B/A-I ratio in the studied participants was 0.68, with values ranging from 0.27 to 1.46. The percentage of participants with the apoB/apoA-I ratio exceeding 0.8 (the cutoff value for CVD risk) was 24.2%. The participants with apoB/apoA-I >0.8 were characterized by higher mean TC (216 mg/dl vs. 171 mg/dl; P < 0.001), TG (80 mg/dl vs. 66 mg/dl; P = 0.007), LDL-C (163 mg/dl vs. 120 mg/dl; P < 0.001), and lower HDL-C (36 mg/dl vs. 43 mg/dl; P < 0.001) compared with women with apoB/apoA-I < 0.8. Conclusion: This study has demonstrated that the women with apo B/A1 >0.8 have worse atherogenic lipid profile (high plasma TC, TG, low-density lipoprotein cholesterol, and low high-density cholesterol). It has also shown that only the apoB/A-I ratio correlates with other lipid markers; it should be considered as a potential useful tool in cardiovascular risk assessment in women. Its potential use in the national guideline for assessment and management of dyslipidemia will be invaluable.Olufisayo Gabriel AyoadeSarah Ifreke EssienOyebola SonugaWolters Kluwer Medknow Publicationsarticleapolipoprotein b/a1 ratiocardiovascular diseasedyslipidemiaMedicineRENSahel Medical Journal, Vol 24, Iss 3, Pp 99-103 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	apolipoprotein b/a1 ratio cardiovascular disease dyslipidemia Medicine R
spellingShingle	apolipoprotein b/a1 ratio cardiovascular disease dyslipidemia Medicine R Olufisayo Gabriel Ayoade Sarah Ifreke Essien Oyebola Sonuga Apolipoprotein B/A1 ratio as a potential marker of cardiovascular risk in women
description	Background: There has been a significant steady rise in the prevalence of cardiovascular disease (CVD) among Nigerian women within the last decade. The balance between pro-atherogenic particles and antiatherogenic particles has been markedly reflected in the apolipoprotein B/A1 ratio (Apo B/A1), and this ratio has been shown to be the strongest single lipoprotein-related cardiovascular risk factor. The cutoff value for the apo B/A1 ratio that defines high cardiovascular risk has been proposed to be 0.8 for women. This study is to determine the apo B/A1 ratio in apparently healthy Nigerian women and to evaluate the relationship of this ratio with other lipid indices. Methods: A total of 161 apparently healthy female adults between the ages of 30 and 66 years were selected for this study over a period of 6 months. Plasma total cholesterols (TC), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) were measured using the enzymatic methods, whereas low-density lipoprotein cholesterol (LDL-C) was calculated using the Friedewald formula. Apolipoprotein A1 and B were determined using immunoturbidimetry methods. Results: The mean of plasma apo B/A-I ratio in the studied participants was 0.68, with values ranging from 0.27 to 1.46. The percentage of participants with the apoB/apoA-I ratio exceeding 0.8 (the cutoff value for CVD risk) was 24.2%. The participants with apoB/apoA-I >0.8 were characterized by higher mean TC (216 mg/dl vs. 171 mg/dl; P < 0.001), TG (80 mg/dl vs. 66 mg/dl; P = 0.007), LDL-C (163 mg/dl vs. 120 mg/dl; P < 0.001), and lower HDL-C (36 mg/dl vs. 43 mg/dl; P < 0.001) compared with women with apoB/apoA-I < 0.8. Conclusion: This study has demonstrated that the women with apo B/A1 >0.8 have worse atherogenic lipid profile (high plasma TC, TG, low-density lipoprotein cholesterol, and low high-density cholesterol). It has also shown that only the apoB/A-I ratio correlates with other lipid markers; it should be considered as a potential useful tool in cardiovascular risk assessment in women. Its potential use in the national guideline for assessment and management of dyslipidemia will be invaluable.
format	article
author	Olufisayo Gabriel Ayoade Sarah Ifreke Essien Oyebola Sonuga
author_facet	Olufisayo Gabriel Ayoade Sarah Ifreke Essien Oyebola Sonuga
author_sort	Olufisayo Gabriel Ayoade
title	Apolipoprotein B/A1 ratio as a potential marker of cardiovascular risk in women
title_short	Apolipoprotein B/A1 ratio as a potential marker of cardiovascular risk in women
title_full	Apolipoprotein B/A1 ratio as a potential marker of cardiovascular risk in women
title_fullStr	Apolipoprotein B/A1 ratio as a potential marker of cardiovascular risk in women
title_full_unstemmed	Apolipoprotein B/A1 ratio as a potential marker of cardiovascular risk in women
title_sort	apolipoprotein b/a1 ratio as a potential marker of cardiovascular risk in women
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/4b90a1c0630640a1a618b82792c60476
work_keys_str_mv	AT olufisayogabrielayoade apolipoproteinba1ratioasapotentialmarkerofcardiovascularriskinwomen AT sarahifrekeessien apolipoproteinba1ratioasapotentialmarkerofcardiovascularriskinwomen AT oyebolasonuga apolipoproteinba1ratioasapotentialmarkerofcardiovascularriskinwomen
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Apolipoprotein B/A1 ratio as a potential marker of cardiovascular risk in women

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