Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis

ABSTRACT Dysbiotic gut microbiota (GM) and disordered metabolic patterns are known to be involved in the clinical expression of atrial fibrillation (AF). However, little evidence has been reported in characterizing the specific changes in fecal microbiota in paroxysmal AF (PAF) and persistent AF (ps...

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Autores principales:	Kun Zuo, Xiandong Yin, Kuibao Li, Jing Zhang, Pan Wang, Jie Jiao, Zheng Liu, Xiaoqing Liu, Jiapeng Liu, Jing Li, Xinchun Yang
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	atrial fibrillation gut microbiota metabolomics metagenomics paroxysmal persistent Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4b93854983344757b58b5a826a548c93
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spelling	oai:doaj.org-article:4b93854983344757b58b5a826a548c932021-11-15T15:29:16ZDifferent Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis10.1128/mSphere.00071-202379-5042https://doaj.org/article/4b93854983344757b58b5a826a548c932020-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00071-20https://doaj.org/toc/2379-5042ABSTRACT Dysbiotic gut microbiota (GM) and disordered metabolic patterns are known to be involved in the clinical expression of atrial fibrillation (AF). However, little evidence has been reported in characterizing the specific changes in fecal microbiota in paroxysmal AF (PAF) and persistent AF (psAF). To provide a comprehensive understanding of GM dysbiosis in AF types, we assessed the GM signatures of 30 PAF patients, 20 psAF patients, and 50 non-AF controls based on metagenomic and metabolomic analyses. Compared with control subjects, similar changes of GM were identified in PAF and psAF patients, with elevated microbial diversity and similar alteration in the microbiota composition. PAF and psAF patients shared the majority of differential taxa compared with non-AF controls. Moreover, the similarity was also illuminated in microbial function and associated metabolic alterations. Additionally, minor disparity was observed in PAF compared with psAF. Several distinctive taxa between PAF and psAF were correlated with certain metabolites and atrial diameter, which might play a role in the pathogenesis of atrial remodeling. Our findings characterized the presence of many common features in GM shared by PAF and psAF, which occurred at the self-terminating PAF. Preventative and therapeutic measures targeting GM for early intervention to postpone the progression of AF are highly warranted. IMPORTANCE Atrial fibrillation has been identified to be associated with disordered gut microbiota. Notably, atrial fibrillation is a progressive disease and could be categorized as paroxysmal and persistent based on the duration of the episodes. The persistent atrial fibrillation patients are accompanied by higher risk of stroke and lower success rate of rhythm control. However, the microbial signatures of different categories of atrial fibrillation patients remain unknown. We sought to determine whether disordered gut microbiota occurs in the self-terminating PAF or intestinal flora develops dynamically during atrial fibrillation progression. We found that different types of atrial fibrillation show a limited degree of gut microbiota shift. Gut microbiota dysbiosis has already occurred in mild stages of atrial fibrillation, which might act as an early modulator of disease, and therefore may be regarded as a potential target to postpone atrial fibrillation progression.Kun ZuoXiandong YinKuibao LiJing ZhangPan WangJie JiaoZheng LiuXiaoqing LiuJiapeng LiuJing LiXinchun YangAmerican Society for Microbiologyarticleatrial fibrillationgut microbiotametabolomicsmetagenomicsparoxysmalpersistentMicrobiologyQR1-502ENmSphere, Vol 5, Iss 2 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	atrial fibrillation gut microbiota metabolomics metagenomics paroxysmal persistent Microbiology QR1-502
spellingShingle	atrial fibrillation gut microbiota metabolomics metagenomics paroxysmal persistent Microbiology QR1-502 Kun Zuo Xiandong Yin Kuibao Li Jing Zhang Pan Wang Jie Jiao Zheng Liu Xiaoqing Liu Jiapeng Liu Jing Li Xinchun Yang Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis
description	ABSTRACT Dysbiotic gut microbiota (GM) and disordered metabolic patterns are known to be involved in the clinical expression of atrial fibrillation (AF). However, little evidence has been reported in characterizing the specific changes in fecal microbiota in paroxysmal AF (PAF) and persistent AF (psAF). To provide a comprehensive understanding of GM dysbiosis in AF types, we assessed the GM signatures of 30 PAF patients, 20 psAF patients, and 50 non-AF controls based on metagenomic and metabolomic analyses. Compared with control subjects, similar changes of GM were identified in PAF and psAF patients, with elevated microbial diversity and similar alteration in the microbiota composition. PAF and psAF patients shared the majority of differential taxa compared with non-AF controls. Moreover, the similarity was also illuminated in microbial function and associated metabolic alterations. Additionally, minor disparity was observed in PAF compared with psAF. Several distinctive taxa between PAF and psAF were correlated with certain metabolites and atrial diameter, which might play a role in the pathogenesis of atrial remodeling. Our findings characterized the presence of many common features in GM shared by PAF and psAF, which occurred at the self-terminating PAF. Preventative and therapeutic measures targeting GM for early intervention to postpone the progression of AF are highly warranted. IMPORTANCE Atrial fibrillation has been identified to be associated with disordered gut microbiota. Notably, atrial fibrillation is a progressive disease and could be categorized as paroxysmal and persistent based on the duration of the episodes. The persistent atrial fibrillation patients are accompanied by higher risk of stroke and lower success rate of rhythm control. However, the microbial signatures of different categories of atrial fibrillation patients remain unknown. We sought to determine whether disordered gut microbiota occurs in the self-terminating PAF or intestinal flora develops dynamically during atrial fibrillation progression. We found that different types of atrial fibrillation show a limited degree of gut microbiota shift. Gut microbiota dysbiosis has already occurred in mild stages of atrial fibrillation, which might act as an early modulator of disease, and therefore may be regarded as a potential target to postpone atrial fibrillation progression.
format	article
author	Kun Zuo Xiandong Yin Kuibao Li Jing Zhang Pan Wang Jie Jiao Zheng Liu Xiaoqing Liu Jiapeng Liu Jing Li Xinchun Yang
author_facet	Kun Zuo Xiandong Yin Kuibao Li Jing Zhang Pan Wang Jie Jiao Zheng Liu Xiaoqing Liu Jiapeng Liu Jing Li Xinchun Yang
author_sort	Kun Zuo
title	Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis
title_short	Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis
title_full	Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis
title_fullStr	Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis
title_full_unstemmed	Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis
title_sort	different types of atrial fibrillation share patterns of gut microbiota dysbiosis
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/4b93854983344757b58b5a826a548c93
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Different Types of Atrial Fibrillation Share Patterns of Gut Microbiota Dysbiosis

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