Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians.

<h4>Background</h4>Besides being responsible for energy production in the cell, mitochondria are central players in apoptosis as well as the main source of harmful reactive oxygen species. Therefore, it can be hypothesised that sequence variation in the mitochondrial genome is a contribu...

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Autores principales:	Edith E Mueller, Waltraud Eder, Johannes A Mayr, Bernhard Paulweber, Wolfgang Sperl, Wolfgang Horninger, Helmut Klocker, Barbara Kofler
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4b94094990bb4a9c9aa9082f60186f12
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spelling	oai:doaj.org-article:4b94094990bb4a9c9aa9082f60186f122021-11-25T06:21:24ZMitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians.1932-620310.1371/journal.pone.0006370https://doaj.org/article/4b94094990bb4a9c9aa9082f60186f122009-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19636411/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Besides being responsible for energy production in the cell, mitochondria are central players in apoptosis as well as the main source of harmful reactive oxygen species. Therefore, it can be hypothesised that sequence variation in the mitochondrial genome is a contributing factor to the etiology of diseases related to these different cellular events, including cancer. The aim of the present study was to assess the frequency of haplogroups and polymorphisms in the control region (CR) of mitochondrial DNA of peripheral blood mononuclear cells from patients with prostate carcinoma (n = 304) versus patients screened for prostate disease but found to be negative for cancer on biopsy (n = 278) in a Middle European population.<h4>Methodology/principal findings</h4>The nine major European haplogroups and the CR polymorphisms were identified by means of primer extension analysis and DNA sequencing, respectively. We found that mitochondrial haplogroup frequencies and CR polymorphisms do not differ significantly between patients with or without prostate cancer, implying no impact of inherited mitochondrial DNA variation on predisposition to prostate carcinoma in a Middle European population.<h4>Conclusions/significance</h4>Our results contrast with a recent report claiming an association between mtDNA haplogroup U and prostate cancer in a North American population of caucasian descent.Edith E MuellerWaltraud EderJohannes A MayrBernhard PaulweberWolfgang SperlWolfgang HorningerHelmut KlockerBarbara KoflerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 7, p e6370 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Edith E Mueller Waltraud Eder Johannes A Mayr Bernhard Paulweber Wolfgang Sperl Wolfgang Horninger Helmut Klocker Barbara Kofler Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians.
description	<h4>Background</h4>Besides being responsible for energy production in the cell, mitochondria are central players in apoptosis as well as the main source of harmful reactive oxygen species. Therefore, it can be hypothesised that sequence variation in the mitochondrial genome is a contributing factor to the etiology of diseases related to these different cellular events, including cancer. The aim of the present study was to assess the frequency of haplogroups and polymorphisms in the control region (CR) of mitochondrial DNA of peripheral blood mononuclear cells from patients with prostate carcinoma (n = 304) versus patients screened for prostate disease but found to be negative for cancer on biopsy (n = 278) in a Middle European population.<h4>Methodology/principal findings</h4>The nine major European haplogroups and the CR polymorphisms were identified by means of primer extension analysis and DNA sequencing, respectively. We found that mitochondrial haplogroup frequencies and CR polymorphisms do not differ significantly between patients with or without prostate cancer, implying no impact of inherited mitochondrial DNA variation on predisposition to prostate carcinoma in a Middle European population.<h4>Conclusions/significance</h4>Our results contrast with a recent report claiming an association between mtDNA haplogroup U and prostate cancer in a North American population of caucasian descent.
format	article
author	Edith E Mueller Waltraud Eder Johannes A Mayr Bernhard Paulweber Wolfgang Sperl Wolfgang Horninger Helmut Klocker Barbara Kofler
author_facet	Edith E Mueller Waltraud Eder Johannes A Mayr Bernhard Paulweber Wolfgang Sperl Wolfgang Horninger Helmut Klocker Barbara Kofler
author_sort	Edith E Mueller
title	Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians.
title_short	Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians.
title_full	Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians.
title_fullStr	Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians.
title_full_unstemmed	Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians.
title_sort	mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in middle european caucasians.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/4b94094990bb4a9c9aa9082f60186f12
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Mitochondrial haplogroups and control region polymorphisms are not associated with prostate cancer in Middle European Caucasians.

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